Pharmacokinetic/pharmacodynamic analyses of plasma pathophysiology biomarkers in subjects with early Alzheimer's disease following lecanemab treatment [0.03%]
莱卡单抗治疗早期阿尔茨海默病患者后对血浆病理生理生物标志物的药代动力学/药效学分析
Pratik Bhagunde,Natasha Penner,Brian A Willis et al.
Pratik Bhagunde et al.
Introduction: Lecanemab, a novel monoclonal antibody targeting both neurotoxic amyloid beta (Aβ) protofibrils and Aβ plaques, substantially reduces markers of amyloid and significantly slows clinical decline on multiple...
Physical activity attenuates the association between allostatic load and early Alzheimer's disease-related biomarkers in older adults [0.03%]
身体活动减轻了allostatic负荷与老年人早期阿尔茨海默病相关生物标志物之间的关联
Géraldine Poisnel,Mathilde Lhérault,Cassandre Palix et al.
Géraldine Poisnel et al.
Introduction: Allostatic load (AL), an index of cumulative physiological dysregulation from chronic stress, may contribute to Alzheimer's disease (AD) pathophysiology by accelerating brain aging. Higher AL has been associ...
The multifaceted roles of the transcription factor SP1 in the pathogenesis of Alzheimer's disease: From molecular regulation to therapeutic targets [0.03%]
转录因子SP1在阿尔茨海默病发病机制中的多面作用：从分子调控到治疗靶点
Zhengxiang Lv,Xiaodong Liu,Qin Huang et al.
Zhengxiang Lv et al.
Alzheimer's disease (AD) is driven by interrelated pathologies, including the accumulation of amyloid β (Aβ), tau pathology, chronic neuroinflammation, and oxidative stress (OS). These pathological processes collectively lead to progressi...
Neuroprotection trial design in progressive supranuclear palsy: challenges and solutions [0.03%]
进行进展性核上性麻痹神经保护研究的设计：面临的挑战和解决方案
Lawrence I Golbe,Ronald G Thomas
Lawrence I Golbe
Introduction: We review the specific challenges posed to neuroprotective trial design by progressive supranuclear palsy (PSP), a rare disorder difficult to diagnose and to assess quantitatively. ...
Promotores program to increase Hispanic/Latino(a) participation in Alzheimer's disease research [0.03%]
促进西班牙裔/拉丁美洲人参与阿尔茨海默病研究的推广计划
Zvinka Z Zlatar,Christina Gigliotti,Ivonne Arias et al.
Zvinka Z Zlatar et al.
Introduction: Hispanic/Latino(a/x) (H/L) representation in Alzheimer's disease and related dementias (ADRD) research remains low, limiting generalizability of findings and interventions to this growing population. H/L com...
A potential multimodal biomarker - cognitive signature associated with the conversion from subjective cognitive decline to mild cognitive impairment [0.03%]
一种潜在的多模态生物标志物-主观认知下降转化为轻度认知障碍的认知谱型
Mohamed Haddad,Mohamed Raâfet Ben Khedher,Chadi Ouechtati et al.
Mohamed Haddad et al.
Introduction: The disruption of key mechanisms involved in amyloid beta (Aβ) clearance during the early stages of dementia may contribute to the progression of cognitive decline toward irreversible brain damage. In this ...
The words community dwelling, Spanish-preferring Mexican/Mexican American adults use to talk about Alzheimer's disease and genetic testing: Implications for education and outreach [0.03%]
关于阿尔茨海默病和基因检测 西语裔墨西哥/美籍墨西哥成人使用的语言及其对教育与外展活动的意义
Jamie C Fong,Fatima I Chavez,Karla Silos et al.
Jamie C Fong et al.
Introduction: Hispanic/Latino (H/L) adults are more likely than non-Hispanic White individuals to have Alzheimer's disease (AD), yet fewer than one in five H/L adults has apolipoprotein E (APOE) Ɛ4, underscoring gaps in ...
The I-Learn Cognition and Behavior program for non-pharmacological treatment of agitation in nursing home residents with neurocognitive disorders: A cluster randomized trial [0.03%]
用于护理机构神经认知障碍居民非药物治疗激越的I-LEARN认知行为方案-cluster随机对照试验
Céline Lourdel,Alix Launay,Alexia Couteau et al.
Céline Lourdel et al.
Introduction: The "I-Learn Cognition and Behavior" program, integrating e-learning and simulation, aims to equip long-term care facility staff with non-pharmacological approaches for managing agitation in residents with n...
Weight loss and metabolic improvements dominate the microbiome response in the MIND diet intervention: a randomized controlled trial [0.03%]
地中海饮食干预中体重和代谢改善主导微生物组反应：一项随机对照试验
Robin M Voigt,Adit Chaudhary,Ankur Naqib et al.
Robin M Voigt et al.
Introduction: Observational studies link the MIND diet to reduced risk of Alzheimer's disease (AD) and slower cognitive decline. However, a recent randomized controlled trial found no differential cognitive benefit of the...
Decentralizing dementia research to the US-Mexico border: the Rio Grande Valley AD-RCMAR as a model for translational equity [0.03%]
分散进行美国与墨西哥边境（里奥格兰德谷区）阿尔茨海默病研究：AD-RCMAR为转化平等性的模式案例
Gladys E Maestre,John Blangero,Eron G Manusov et al.
Gladys E Maestre et al.
Translational equity means ensuring that diagnostics, treatments, care models, and prevention strategies are developed and implemented so they work for populations with the greatest burden and least access to care. In Alzheimer's disease an...