Cerebrospinal fluid α-synuclein and Aβ42 link with default mode and salience networks connectivity in dementia with Lewy bodies [0.03%]
路易体痴呆中脑脊液α-突触核蛋白和Aβ42与默认模式和感觉异常网络连接性的联系
Vincent Gabriel,Elena Chabran,Marion Sourty et al.
Vincent Gabriel et al.
Introduction: Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are neurocognitive disorders characterized by distinct but often overlapping pathological processes. These include α-synuclein, amyloid-beta 42 (...
Advances in pharmacotherapy for vascular cognitive impairment and vascular dementia: An update of 2025 [0.03%]
血管性认知障碍和血管性痴呆的药物治疗进展（2025年更新）
Doan-Khanh Tran,Yi-Chun Kuan,Li-Kai Huang et al.
Doan-Khanh Tran et al.
Vascular cognitive impairment (VCI), including vascular dementia (VaD), encompasses a spectrum of cognitive deficits resulting from cerebrovascular pathology, ranging from mild impairment to dementia. As the second leading cause of dementia...
Response to "Reanalyzing the impact of cognitive training over 20 years in the ACTIVE study: Losing the forest in the trees" [0.03%]
对“重新分析ACTIVE研究中认知训练20年的影响：在树木中失去森林”的回应
Alden L Gross,George W Rebok,Marilyn S Albert
Alden L Gross
Anti-amyloid nanobody-Fc fusion protein drives potent amyloid clearance through microglial recruitment [0.03%]
一种抗淀粉样蛋白的纳米抗体融合蛋白通过募集小胶质细胞实现高效清除淀粉样蛋白的功效
Zonghui Ding,Katelin A Gibson,David G Nascari et al.
Zonghui Ding et al.
Introduction: Anti-amyloid beta (Aβ) monoclonal antibodies are effective at lowering amyloid in Alzheimer's disease (AD). However, whether Fc-mediated effector function is absolutely required for efficacy is not complete...
Heterogeneous responses to memantine in Alzheimer's disease: A precision medicine approach using iPSC models [0.03%]
阿尔茨海默病对美金刚的异质性反应：使用诱导多能干细胞模型的精准医疗方法
Cristina Zivko,Ram Sagar,Waqar Ahmed et al.
Cristina Zivko et al.
Introduction: Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive and functional decline. Memantine, a commonly prescribed N-methyl-D-aspartate receptor antagonist, appe...
Reprogramming lipid metabolism for cognitive restoration in Alzheimer's via PLA2G4E [0.03%]
通过PLA2G4E重新编程脂质代谢以恢复阿尔茨海默病患者的认知功能
Sara Badesso,María Espelosín,Cristina Alonso et al.
Sara Badesso et al.
Introduction: Growing evidence implicates dysregulated brain lipid metabolism in Alzheimer's disease (AD) pathogenesis, influencing membrane integrity, neuroinflammation, and amyloid beta and tau pathology, thereby repres...
Identifying populations with faster cognitive decline using blood-based biomarkers [0.03%]
利用血液生物标志物识别认知衰退更快的群体
James Russell Pike,Yongmei Liu,Theresa Chisolm et al.
James Russell Pike et al.
Introduction: Identifying individuals who undergo cognitive decline is vital to the success of prevention trials that aim to slow cognitive decline. Yet, the benefits of using blood-based biomarkers of neurodegeneration, ...
Real-time digital assessment of sleep-cognition dynamics in dementia care dyads [0.03%]
痴呆照料双方的睡眠认知动态的实时数字评估
Yeonsu Song,Carter Peterson-Meyer,Laura M Campbell et al.
Yeonsu Song et al.
Introduction: Sleep disturbance is common in persons living with dementia (PLWD) and may contribute to day-to-day variability in cognitive functioning, with implications for daily activities and caregiving. However, tradi...
The Indiana University Brain Health Program to deliver amyloid-targeted therapy to Alzheimer's disease patients [0.03%]
印第安纳大学脑健康项目向阿尔茨海默病患者提供针对淀粉样蛋白的治疗疗法
Jared R Brosch,Sophia Wang,Liana G Apostolova et al.
Jared R Brosch et al.
Introduction: The Indiana University Brain Health Program was developed to support safe implementation of amyloid-targeting therapies (ATTs) for early Alzheimer's disease (AD). ...
Association of SPHK1 polymorphisms with Alzheimer's disease susceptibility: Functional impact of the rs2247856 SNP on transcriptional efficiency [0.03%]
SPHK1基因多态性与阿尔茨海默病易感性的关联：rs2247856多态性对转录效率的功能影响
Dong-Ju Kim,Yong-Chan Kim,Byung-Hoon Jeong
Dong-Ju Kim
Introduction: Sphingosine kinase 1 (SPHK1) has been implicated in the regulation of pro-resolving lipid mediators relevant to neuroinflammation in Alzheimer's disease (AD). However, no studies have evaluated the genetic a...