Cardiorespiratory fitness modifies the relationship between arterial stiffness and cerebral blood flow independent of physical activity [0.03%]
有氧运动能力改变动脉僵硬度和脑血流的关系独立于体力活动
Brianne M Breidenbach,Ira Driscoll,Matthew P Glittenberg et al.
Brianne M Breidenbach et al.
Introduction: Central arterial stiffness and cerebral blood flow (CBF) are inversely related. Poor cardiorespiratory fitness (CRF) and low physical activity (PA) are related to both higher arterial stiffness and lower CBF...
A common outcome set for trials in dementia with Lewy bodies (DLB COS) [0.03%]
狄扬 Bodies痴呆症临床试验通用结果集(DLB COS)
Joseph P M Kane,Rachel L Fitzpatrick,Sara Betzhold et al.
Joseph P M Kane et al.
Introduction: Methodological heterogeneity in dementia with Lewy bodies (DLB) trials contributes to publication bias and makes evidence synthesis and meta-analysis challenging. We aimed to develop a core outcome set for D...
Correction to "The HOPE4MCI study: AGB101 treatment slows progression of entorhinal cortex atrophy in APOE ε4 non-carriers with mild cognitive impairment due to Alzheimer's disease" [0.03%]
有关HOPE4MCI研究的更正：对于因阿尔茨海默病轻度认知障碍且不携带APOEε4等位基因患者的AGB101治疗可减缓内侧颞叶萎缩
[This corrects the article DOI: 10.1002/trc2.70004.]. © 2025 The Author(s). Alzheimer's & Dementia: Translational Research & Clinical Interventions publ...
Published Erratum
Alzheimer's & dementia (New York, N. Y.). 2025 Jul 10;11(3):e70131. DOI:10.1002/trc2.70131 2025
Mind your nose: A randomized controlled trial of olfactory-based memory training for older people with subjective cognitive decline [0.03%]
谨防大脑衰退：老年人主观认知下降的嗅觉记忆训练随机对照试验
Isabelle J M Burke,Courtney Chesser,Christopher P K Brown et al.
Isabelle J M Burke et al.
Introduction: Olfactory-based cognitive training may be of benefit to individuals at risk of dementia given the strong association between olfactory impairment and cognitive decline. The Mind Your Nose (MYN) trial compare...
Response to: Refining the clinical interpretation of activity variability in cognitive impairment: The need for phenotypic specificity [0.03%]
对《认知障碍活动中枢变异临床解释的完善：特异性表型的需要》一文的评论
Patrick T Donahue,Jennifer A Schrack,Johannes Thrul et al.
Patrick T Donahue et al.
Physical activity as a resistance or resilience mechanism in Down syndrome Alzheimer's disease [0.03%]
唐氏综合症阿尔茨海默病的抵抗或恢复机制中的身体活动
Victoria L Fleming,Jamie Peven,Brian C Helsel et al.
Victoria L Fleming et al.
Introduction: Adults with Down syndrome (DS) are at risk for Alzheimer's disease (AD). Lifestyle factors such as engagement in moderate-to-vigorous physical activity (MVPA) reduce risk or delay the onset of AD. This study...
The impact of estimated cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline [0.03%]
估计的心肺适能对阿尔茨海默病生物标志物及其与认知下降关系的影响
Adam J Paulsen,Ira Driscoll,Brianne M Breidenbach et al.
Adam J Paulsen et al.
Introduction: The accumulation of core Alzheimer's disease (AD) pathology contributes to cognitive decline. Cardiorespiratory fitness (CRF) influences AD pathological progression resulting in improvement or maintenance of...
A splice-switching antisense oligonucleotide targeting APP reduces accumulation of α-synuclein in a mouse model of Parkinson's disease [0.03%]
针对APP的拼接开关反义寡核苷酸在帕金森病小鼠模型中减少α-突触核蛋白的积累
Rijwan U Ahammad,Brian Spencer,Bao Quach et al.
Rijwan U Ahammad et al.
Introduction: Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders characterized by abnormal protein aggregation, with amyloid beta (Aβ) and α-synuclein (α-syn) as key pathological mark...
Why testing and diagnosis for Alzheimer's disease are mission critical [0.03%]
为什么对阿尔茨海默病进行检测和诊断至关重要
Brent W Beasley
Brent W Beasley
The author, a physician who has younger-onset Alzheimer's disease (AD), recounts his recent lunch with a former coworker who has had a stroke. The author makes the point that because we now have an effective treatment for AD, and phosphoryl...