Alzheimers & dementia-translational research & clinical interventions文章索引

First-in-human, double-blind, placebo-controlled, single-dose escalation study of aducanumab (BIIB037) in mild-to-moderate Alzheimer's disease [0.03%] 针对轻中度阿尔茨海默病患者的单次给药递增剂量的aducanumab(BIIB037)首次人体、双盲、安慰剂对照I期临床试验

James Ferrero,Leslie Williams,Heather Stella et al. James Ferrero et al.

Introduction: Aducanumab (BIIB037), a human monoclonal antibody selective for aggregated forms of amyloid beta, is being investigated as a disease-modifying treatment for Alzheimer's disease (AD). ...

Alzheimer's & dementia (New York, N. Y.). 2016 Jun 20;2(3):169-176. DOI:10.1016/j.trci.2016.06.002 2016

Poor cerebrovascular function is an early marker of cognitive decline in healthy postmenopausal women [0.03%] 较差的脑血管功能是健康绝经后妇女认知能力下降的早期标志

Rachel H X Wong,Hamish M Evans,Peter R C Howe Rachel H X Wong

Introduction: Impairment of cerebrovascular function becomes evident after menopause. No study has yet explored relationships between deficits in cerebrovascular function, cognitive performance, and mood in postmenopausal...

Alzheimer's & dementia (New York, N. Y.). 2016 Aug 3;2(3):162-168. DOI:10.1016/j.trci.2016.07.003 2016

B-vitamins are potentially a cost-effective population health strategy to tackle dementia: Too good to be true? [0.03%] B族维生素可能是防治痴呆具有成本效益的公共卫生策略吗？

Apostolos Tsiachristas,A David Smith Apostolos Tsiachristas

Introduction: To respond to the threat of dementia to public health and the economy, we need to prioritize research resources on strategies that would be the most effective. In relation to the prevention of dementia, this...

Review Alzheimer's & dementia (New York, N. Y.). 2016 Aug 11;2(3):156-161. DOI:10.1016/j.trci.2016.07.002 2016

NPT088 reduces both amyloid-β and tau pathologies in transgenic mice [0.03%] NPT088可同时减少tau和淀粉样蛋白的病理损害

Jonathan M Levenson,Sally Schroeter,Jenna C Carroll et al. Jonathan M Levenson et al.

Introduction: Alzheimer's disease (AD) is characterized by appearance of both extracellular senile plaques and intracellular neurofibrillary tangles, comprised of aggregates of misfolded amyloid-β (Aβ) and hyper-phospho...

Alzheimer's & dementia (New York, N. Y.). 2016 Jul 14;2(3):141-155. DOI:10.1016/j.trci.2016.06.004 2016

Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease [0.03%] 静脉注射免疫球蛋白在阿尔茨海默病长期、安慰剂对照研究中的安全性展示（老年患者）

David Gelmont,Ronald G Thomas,Jonathan Britt et al. David Gelmont et al.

Introduction: We present safety results from a study of Gammagard Liquid intravenous immunoglobulin (IGIV) in patients with probable Alzheimer's disease. ...

Alzheimer's & dementia (New York, N. Y.). 2016 Jun 21;2(2):131-139. DOI:10.1016/j.trci.2016.06.003 2016

Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer's disease [0.03%] 氟哌啶醇通过灭活AMPK降低tau蛋白磷酸化水平以改善AD小鼠模型的认知缺陷

Jeremy Koppel,Heidy Jimenez,Leslie Adrien et al. Jeremy Koppel et al.

Introduction: The use of antipsychotic medications in Alzheimer's disease has been associated with an increased risk of mortality in clinical trials. However, an older postmortem literature suggests that those with schizo...

Alzheimer's & dementia (New York, N. Y.). 2016 Jun 21;2(2):121-130. DOI:10.1016/j.trci.2016.05.003 2016

A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects [0.03%] 贝沙罗汀对健康人群淀粉样蛋白和载脂蛋白E代谢影响的随机对照研究

Kaushik Ghosal,Michael Haag,Philip B Verghese et al. Kaushik Ghosal et al.

Introduction: We conducted a phase Ib proof of mechanism trial to determine whether bexarotene (Targretin) increases central nervous system (CNS) apolipoprotein E (apoE) levels and alters Aβ metabolism in normal healthy ...

Alzheimer's & dementia (New York, N. Y.). 2016 Jun 17;2(2):110-120. DOI:10.1016/j.trci.2016.06.001 2016

The roles of inflammation and immune mechanisms in Alzheimer's disease [0.03%] 炎症和免疫机制在阿尔茨海默病中的作用

Linda J Van Eldik,Maria C Carrillo,Patricia E Cole et al. Linda J Van Eldik et al.

The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune cells, particularly microglia and astrocyte...

Review Alzheimer's & dementia (New York, N. Y.). 2016 May 30;2(2):99-109. DOI:10.1016/j.trci.2016.05.001 2016

Assessing reliability of short and tick box forms of the ANU-ADRI: Convenient alternatives of a self-report Alzheimer's disease risk assessment [0.03%] 简短和复选框形式的ANU-ADRI评估的可靠性：阿尔茨海默病自评风险评估的便捷选择

Sarang Kim,Nicolas Cherbuin,Kaarin J Anstey Sarang Kim

Introduction: To assess the reliability of short versions of the Australian National University Alzheimer's Disease Risk Index (ANU-ADRI). Methods: ...

Alzheimer's & dementia (New York, N. Y.). 2016 Apr 3;2(2):93-98. DOI:10.1016/j.trci.2016.03.001 2016

The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease [0.03%] ALFA项目：一个识别阿尔茨海默病早期病理生理特征的研究平台

José Luis Molinuevo,Nina Gramunt,Juan Domingo Gispert et al. José Luis Molinuevo et al.

Introduction: The preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project, including the ALFA ...

Alzheimer's & dementia (New York, N. Y.). 2016 Mar 3;2(2):82-92. DOI:10.1016/j.trci.2016.02.003 2016