The moderating effect of dietary fiber and protein on the relationship between symptoms of depression and anxiety and cognitive decline [0.03%]
膳食纤维和蛋白质对抑郁焦虑症状与认知衰退关系的调节作用研究
Samantha L Gardener,Hilal Salim Said Al Shamsi,Stephanie R Rainey-Smith et al.
Samantha L Gardener et al.
Introduction: Depression and anxiety often co-occur with Alzheimer's disease, exacerbating the associated cognitive impairment. This study examined moderating effects of dietary protein and fiber intake on relationships b...
SIRT6 signaling as an underexplored mechanistic node in nanoformulation-based neuroinflammation therapy for Alzheimer's disease [0.03%]
基于纳米药物的阿尔茨海默病神经炎症治疗中鲜少被探索的SIRT6信号节点机制研究
Ahmed S Mancy
Ahmed S Mancy
Chronic microglial neuroinflammation is a core driver of Alzheimer's disease (AD). Wei et al. recently reported a blood-brain barrier (BBB)-penetrating, microglia-targeting nanomodulator (Res@TcMNP/ASO) that simultaneously suppressed NF-κB...
Thalamic volume alterations mediate glymphatic function and cognitive dysfunction in Alzheimer's disease [0.03%]
丘脑体积改变介导阿尔茨海默病中胶淋巴功能和认知障碍的关系
Leian Chen,Xiao Zhou,Bin Zhang et al.
Leian Chen et al.
Introduction: Glymphatic dysfunction is implicated in Alzheimer's disease (AD), but its mechanism remains unclear. This study investigated the associations of the analysis along the perivascular space (ALPS) index, brain ...
Pharmacodynamic and stage-dependent therapeutic efficacy of SFRP1 neutralization in a mouse model of Alzheimer's disease [0.03%]
在阿尔茨海默病小鼠模型中SFRP1中和的药理动力学及阶段依赖性治疗效果
Pablo Miaja,Marcos Martinez-Baños,María Jesús Martin-Bermejo et al.
Pablo Miaja et al.
Introduction: Alzheimer's disease (AD) is characterized by early synaptic dysfunction followed by progressive amyloid beta (Aβ) accumulation, neuroinflammation, and cognitive decline. We previously identified secreted fr...
Associations between neuronavigated rTMS-mediated functional connectome plasticity and neurotransmitter receptors in Alzheimer's disease [0.03%]
阿尔茨海默病患者神经导航重复经颅磁刺激介导的功能连接体可塑性与神经递质受体之间的关系
Weina Yao,Tingyu Lv,Wenao Zheng et al.
Weina Yao et al.
Introduction: Cognitive improvement is mediated by repetitive transcranial magnetic stimulation (rTMS) in Alzheimer's disease (AD), and connectome gradient analysis has important potential to explore more comprehensive in...
Six-month real-world amyloid PET outcomes after lecanemab: Greater amyloid reduction at the MCI stage than in dementia [0.03%]
莱卡奈单抗6个月真实世界淀粉样PET结果：轻度认知障碍期淀粉样斑块减少幅度大于痴呆期
Geon Ha Kim,Hai-Jeon Yoon,Eun Hee Kim et al.
Geon Ha Kim et al.
Introduction: Evidence from routine clinical practice regarding stage-dependent responses to lecanemab remains limited. We examined early amyloid positron emission tomography (PET) and clinical trajectories according to d...
Short-term psychological impacts of Alzheimer's disease risk disclosure based on blood-biomarker results [0.03%]
基于血液生物标志物结果的阿尔茨海默病风险告知的短期心理影响
Bhargavi Ramamurthy,Adena Cho,Maryam Abdolmaleki et al.
Bhargavi Ramamurthy et al.
Introduction: Blood-based biomarkers (BBMs) of Alzheimer's disease (AD) provide important information about risk for dementia, but little is known about the psychological impact of sharing BBM results to participants with...
Agentic neurotechnology: A multi-agent AI framework for next-generation dementia care [0.03%]
代理人神经技术：下一代痴呆症护理的多代理人工智能框架
Kevin Mekulu,Faisal Aqlan,Hui Yang
Kevin Mekulu
Dementia care is reaching a technological turning point as rapid advances in artificial intelligence (AI), digital biomarkers, and sensor-based monitoring continue to outpace current clinical practice. Yet most tools remain episodic and dis...
The proteomic and metabolomic signature of inherited chromosomally integrated HHV-6 and its role in all-cause dementia and mortality risk: The UK Biobank study [0.03%]
人类遗传染色体整合HHV-6的蛋白组和代谢组标志及其在全因痴呆和死亡风险中的作用：英国生物银行研究
May A Beydoun,Minkyo Song,Choa Yun et al.
May A Beydoun et al.
Objective: To examine associations of inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) with incident dementia and mortality, characterize proteomic and metabolomic correlates of carrier status, and evalua...
Diversity and inclusivity in Australian dementia prevention research: A mixed methods review [0.03%]
澳大利亚痴呆症预防研究中的多样性和包容性：混合方法综述
Olivia E Giameos,Maddison L Mellow,Diana Karamacoska et al.
Olivia E Giameos et al.
Minoritized communities are disproportionately impacted by modifiable dementia risk factors but are underrepresented in dementia research globally. In Australia, the number of dementia prevention cohort and intervention studies has rapidly ...