Assessing safety and efficacy in subpopulations in Alzheimer's disease clinical trials: contextualizing representativeness [0.03%]
阿尔茨海默病临床试验中评估亚群的安全性和有效性：上下文中的代表性问题
Guogen Shan,Jeffrey Cummings
Guogen Shan
Efficacy outcomes in clinical trials are based on well-powered analyes of the entire participating population. Trial populations will comprise many types of demographic and biological subgroups, including individuals of different sexes, gro...
Relationship between efficacy and preferential targeting of soluble Aβ aggregates [0.03%]
有效性和优先靶向可溶性Aβ聚集体之间的关系
Johanne M Kaplan,Ebrima Gibbs,Juliane A Coutts et al.
Johanne M Kaplan et al.
Introduction: Amyloid beta (Aβ)-directed antibodies have shown varying degrees of efficacy against Alzheimer's disease (AD). This study explored the relationship between targeting of Aβ molecular species and therapeutic...
Leveraging recent advances in plasma biomarkers to optimize early proof of concept trials in Alzheimer's disease [0.03%]
利用近期关于生物标志物的进展优化阿尔茨海默病早期概念验证试验
Garrett B Duncan,Samuel P Dickson,Johanne M Kaplan et al.
Garrett B Duncan et al.
Introduction: The importance of biomarkers as a primary outcome or as supportive evidence of clinical effect is rising as the field shifts toward disease-modifying treatments and earlier intervention, because they have lo...
Modeling amyloid plaque turnover dynamics improves characterization of drug effects [0.03%]
用于改善药物表征的淀粉样蛋白斑块周转动力学模型
Eline van Maanen,Seth Robey,Idriss Bennacef et al.
Eline van Maanen et al.
Introduction: Effect on amyloid plaque as measured by positron emission tomography imaging with Centiloid standardization of two therapeutic approaches targeting amyloid beta (Aβ) was investigated using exposure-response...
Using AI-generated digital twins to boost clinical trial efficiency in Alzheimer's disease [0.03%]
利用人工智能生成的数字孪生体提高阿尔茨海默病临床试验效率
Deli Wang,Hana Florian,Shau-Yu Lynch et al.
Deli Wang et al.
Introduction: Machine learning models leverage baseline data to create artificial intelligence (AI)-generated digital twins (DTs)-individualized predictions of each participant's clinical outcomes if they had received pla...
Perspectives on meaningful dementia treatment and care from those with lived experience [0.03%]
罹患痴呆症经历者的见解：有意义的治疗和护理观点
Walter Moczygemba,Darlene Bradley,Ralph Carmona et al.
Walter Moczygemba et al.
The ongoing conversations surrounding the importance of minimal clinically important differences and descriptions of meaningful impacts must include the voices of those living with Alzheimer's disease and related dementias. To provide this ...
Polypharmacy and risk of dementia progression in older adults with mild cognitive impairment: A longitudinal cohort study [0.03%]
老年人轻度认知障碍患者用药复杂性与痴呆进展的队列研究
Ying-Hsin Hsu,Chih-Kuang Liang,Ming-Yueh Chou et al.
Ying-Hsin Hsu et al.
Introduction: Polypharmacy is common in older adults with mild cognitive impairment (MCI), but its impact on cognitive decline is unclear. Studies on the association between polypharmacy and cognitive outcomes have yielde...
Lifestyle medicine and brain health: Insights from the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) and the promise of personalization [0.03%]
生活方式医学与脑健康：美国保护大脑健康的生话方式干预研究(U.S.POINTER)带来的启示和个性化医疗的前景
Alfonso Alfini,Ryan J Dougherty
Alfonso Alfini
The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is a landmark 2-year randomized clinical trial evaluating multidomain lifestyle interventions for dementia prevention in older adults at ele...
Developing educational materials to aid in Alzheimer's blood biomarker disclosure [0.03%]
开发教育材料以帮助阿尔茨海默病血液生物标志物的披露
Raymond R Romano rd,Dominic Roby,Sydney Wilhoite et al.
Raymond R Romano rd et al.
Introduction: A crucial step before clinical use of Alzheimer's disease (AD) blood biomarkers is the development of effective methods for disclosing results. This mixed-method study developed educational materials to disc...
Risk factor profiles and cognitive function in older adults: the Brain Health Support Program Study [0.03%]
老年人大脑健康支持项目研究中的风险因素特征及其认知功能
Caroline S Duchaine,Manuel Montero-Odasso,Haakon B Nygaard et al.
Caroline S Duchaine et al.
Background: Dementia risk factors coexist and interact in meaningful ways. Identifying risk profiles can inform prevention strategies. Methods: ...