Reframing Alzheimer's disease as a complex adaptive system: More than an amyloid beta-tau connection [0.03%]
阿尔茨海默病作为复杂自适应系统的重构：不仅仅是β淀粉样蛋白-tau连接关系
Maurizio Giorelli
Maurizio Giorelli
Alzheimer's disease (AD) is the leading cause of dementia, but simple models focusing on amyloid beta and tau only partially explain its variability and limited success in treatment. Evidence from systems biology, neuroimmunology, connectom...
Single-subject proteomic signatures in Alzheimer's disease reflect clinical phenotypes and distinguish asymptomatic from symptomatic cases [0.03%]
单一主体蛋白组标志物反映阿尔茨海默病的临床表现型并区分无症状和有症状患者
Avijit Podder,Yi Juin Liew,Gregory A Cary et al.
Avijit Podder et al.
Introduction: Alzheimer's disease (AD) exhibits considerable inter-individual variability in clinical presentation, neuropathological burden, and underlying molecular processes. Conventional cohort-based analyses of omics...
Effectiveness of Souvenaid® combined with acetylcholinesterase inhibitors on caregiver burden in Alzheimer´s disease [0.03%]
补充Souvenaid®联合胆碱酯酶抑制剂治疗阿尔茨海默病对照料者负担的影响
José María García-Alberca,Silvia Mendoza,Paz DE LA Guía et al.
José María García-Alberca et al.
Introduction: The burden experienced by caregivers of Alzheimer´s disease (AD) patients is a complex and stressful situation influenced by distinct variables, such as the patient´s need for monitoring, social isolation,...
Functional connectome metrics reveal distinct prognostic subtypes in two Phase 3 gantenerumab trials [0.03%]
功能连接网络指标揭示了两项三期甘那单抗临床试验中的预后亚型
Susanna Gobbi,Erica Silvestri,Matteo Tonietto et al.
Susanna Gobbi et al.
Introduction: Alzheimer's disease (AD) heterogeneity poses significant challenges for drug development, identification of individuals at risk, and treatment response prediction. Scientists have leveraged graph theory and ...
Vascular cognitive impairment and dementia drug-development pipeline 2025 [0.03%]
2025年血管性认知障碍和痴呆症药物研发管线
Ying Xu,Perminder S Sachdev,Matthew J Lennon
Ying Xu
Introduction: There are currently no approved medicines for vascular cognitive impairment and dementia (VCID). Methods: We reviewed cli...
Jeffrey L Cummings,Yadi Zhou,Yuxin Yang et al.
Jeffrey L Cummings et al.
Introduction: Discovery and development of new therapies for Alzheimer's disease (AD) are urgently needed to address the world's growing population of individuals on the AD pathophysiological continuum. Clinicaltrials.gov...
Population pharmacokinetics of remlifanserin (ACP-204), a serotonin 2A receptor inverse agonist [0.03%]
雷米法森(ACP-204)的群体药代动力学研究:一种5-HT₂A受体拮抗剂
Mona Darwish,Nancy Lin,Bryan Dirks et al.
Mona Darwish et al.
Introduction: Remlifanserin, or ACP-204, is a potent serotonin 2A receptor inverse agonist under investigation for treatment of Alzheimer's disease psychosis and Lewy body dementia psychosis. A population pharmacokinetics...
Blood DNA methylation signature of cognitive reserve moderates the association between CSF tau pathology and memory in prodromal Alzheimer's disease [0.03%]
血DNA甲基化认知储备标志物通过脑脊液tau病理与轻度认知障碍阶段阿尔茨海默病患者记忆的关系起调节作用
David Lukacsovich,Juan I Young,Lissette Gomez et al.
David Lukacsovich et al.
Introduction: Cognitive reserve (CR) reflects variability in cognitive adaptability that modifies the impact of Alzheimer's disease (AD) pathology on cognition. However, blood-based biomarkers of CR have not been establis...
Peace Esther Johnson,Roxanne Vandermause
Peace Esther Johnson
It is crucial to identify practices that effectively meet the unique spiritual needs of Black persons living with dementia. Currently, ≈ 7 million individuals in the United States are affected by dementia, a figure that is expected to rise...
Druggable genome-wide Mendelian randomization analysis identifies potential treatment targets in vascular dementia [0.03%]
基于药物研发的全基因组孟德尔随机化分析鉴别出血管性痴呆潜在治疗靶点
Matthew J Lennon,Ying Xu,Anbupalam Thalamuthu et al.
Matthew J Lennon et al.
Background: There are currently no US Food and Drug Administration-approved treatments for vascular dementia (VaD). Genome-wide approaches have successfully identified druggable targets and treatments for various disorder...