The caveats of short-cycle antiretroviral therapy in adolescents living with HIV [0.03%]
青少年HIV感染者短期周期抗逆转录病毒治疗的局限性
Romain Palich,Jean-Jacques Parienti
Romain Palich
Efficacy and safety of short-cycle, dolutegravir-based antiretroviral therapy in adolescents living with HIV (BREATHER Plus): a multicentre, open-label, randomised, parallel, two-arm, non-inferiority trial [0.03%]
基于多替拉韦的短周期抗逆转录病毒疗法治疗HIV阳性青少年的有效性和安全性：一项中心参与、开放标签、随机对照非劣效性试验（BREATHER Plus）
Adeodata R Kekitiinwa,Angus Jennings,Mutsa Bwakura-Dangarembizi et al.
Adeodata R Kekitiinwa et al.
Background: Short-cycle antiretroviral therapy (ART), comprising 5 days on and 2 days off treatment, offers the potential for ART-free weekends, reduced toxicity, and improved quality of life for adolescents living with H...
Pitavastatin effects on lipids in relation to major adverse cardiovascular events: a REPRIEVE secondary analysis [0.03%]
匹伐他汀对血脂及主要不良心血管事件影响的再评价试验二次分析
Triin Umbleja,Mohammad U Zafar,Sara McCallum et al.
Triin Umbleja et al.
Background: The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) found a 36% reduction in major adverse cardiovascular events (MACE) with pitavastatin in people with HIV. Little is known about the relationshi...
The Lancet Hiv
The Lancet Hiv
Lindi Masson,Nina Radzey,Andrea G Abrahams et al.
Lindi Masson et al.
Non-optimal vaginal bacteriomes, vulvovaginal candidiasis, and sexually transmitted infections have been associated with increased risk of HIV acquisition in multiple clinical studies. However, there are still major gaps in our understandin...
Risk of obesity, diabetes, hypertension, and major adverse cardiovascular events after a switch to an integrase inhibitor: a target trial emulation in REPRIEVE [0.03%]
整合酶抑制剂治疗与肥胖、糖尿病、高血压及主要心血管不良事件风险：REPRIEVE研究中的目标试验仿真分析
Emma M Kileel,Carlos D Malvestutto,Markella V Zanni et al.
Emma M Kileel et al.
Background: Integrase strand-transfer inhibitors (INSTIs) are linked to weight gain, but data on their cardiometabolic effects, particularly major adverse cardiovascular events (MACE), are scarce. We aimed to estimate the...
Incident diabetes after switching to integrase strand transfer inhibitors in people with HIV in the USA and Canada: a cohort study [0.03%]
美国和加拿大HIV感染者切换至整合酶链转移抑制剂后发生糖尿病的病例：队列研究
Y Joseph Hwang,Catherine R Lesko,Todd T Brown et al.
Y Joseph Hwang et al.
Background: Integrase strand transfer inhibitor (INSTI) initiation has been associated with diabetes in antiretroviral therapy (ART)-naive people with HIV. We aimed to examine the effect of switching to INSTIs on incident...
Jean-Jacques Parienti,Franck Boccara
Jean-Jacques Parienti
Vijay Shankar Balakrishnan
Vijay Shankar Balakrishnan