Efficacy and safety of a mosaic HIV-1 vaccine regimen in men who have sex with men and transgender individuals (HVTN 706/HPX3002/Mosaico): a global, randomised, double-blind, placebo-controlled, phase 3 trial [0.03%]
一项在男性同性恋和变性人中进行的马赛克艾滋病疫苗方案的有效性和安全性研究（HVTN 706/HPX3002/Mosaico）：一项全球性的随机双盲安慰剂对照III期临床试验
Susan P Buchbinder,Sabrina Spinosa Guzman,Jorge Sanchez et al.
Susan P Buchbinder et al.
Background: There is a high unmet need for effective HIV prevention options, including vaccines, for individuals at high risk of HIV acquisition who choose not to use pre-exposure prophylaxis or other prevention strategie...
Clinical Trial
The lancet. HIV. 2025 Dec;12(12):e823-e835. DOI:10.1016/S2352-3018(25)00195-X 2025
Adele Benzaken,Fernanda Fonseca,Penninah Iutung et al.
Adele Benzaken et al.
The Lancet Hiv
The Lancet Hiv
Identifying priority populations for HIV interventions using acquisition and transmission indicators: a combined analysis of 15 mathematical models from ten African countries [0.03%]
利用 Acquisition 和 Transmission 指标识别艾滋病毒干预的优先人群：来自非洲十个国家的十五个数学模型的综合分析
Romain Silhol,Ross D Booton,Kate M Mitchell et al.
Romain Silhol et al.
Background: Characterising disparities in HIV infection across populations by gender, age, and HIV risk is key information to guide intervention priorities. We aimed to assess how indicators measuring HIV acquisitions, tr...
Projecting changes in demographics and causes of death in people with HIV in western Europe from 2025 to 2050: a mathematical modelling study [0.03%]
预测西方国家艾滋病患者人口统计和死亡原因的变化（2025年至2050年）：一项数学建模研究
Julie Ambia,Ard van Sighem,Nikos Pantazis et al.
Julie Ambia et al.
Background: Antiretroviral therapy (ART) scale-up in western Europe has reduced the incidence of AIDS-related conditions, increased life expectancies, and led to an ageing population of people with HIV. We aimed to projec...
Cahal McQuillan
Cahal McQuillan
Functional cure of HIV-1 infection in an exceptional elite controller: a case report [0.03%]
HIV-1感染功能性治愈的特异病例报告
José M Benito,Juan C Lopez-Bernaldo,Katie Fisher et al.
José M Benito et al.
Background: Identifying characteristics associated with functional cure of HIV-1 infection is of pivotal importance. Here, we describe a unique case of functional cure in an exceptional elite controller, comparing immunol...
Sean D Young
Sean D Young
A large and rapidly growing percentage of health-care organisations are implementing artificial intelligence (AI; including generative AI), for research, care delivery, and policy. Despite concerns (eg, ethical considerations and data priva...
Safety outcomes among infants whose mothers used the dapivirine vaginal ring or oral PrEP during pregnancy (MTN-042/DELIVER): a randomised phase 3b study [0.03%]
母亲孕期使用环匹黴芬阴道环或口服PrEP对婴儿安全性的结局：Ⅲb期随机对照试验（MTN-042/DELIVER）
Lee Fairlie,Daniel W Szydlo,Ashley Mayo et al.
Lee Fairlie et al.
Background: HIV acquisition risk during pregnancy remains high and additional data supporting pre-exposure prophylaxis (PrEP) in pregnancy are needed. The aim of the MTN-042/DELIVER study was to evaluate the dapivirine va...
Clinical Trial
The lancet. HIV. 2025 Nov;12(11):e763-e773. DOI:10.1016/S2352-3018(25)00261-9 2025