Persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue [0.03%]
带或不带药物起效线索的暗示暴露治疗无法消除氧化亚氮吸入引起的超热性反向标志的持续存在现象
Karl J Kaiyala,Stephen C Woods,Douglas S Ramsay
Karl J Kaiyala
We asked whether chronic tolerance and the hyperthermic sign-reversal induced by repeated 60% N2O exposures could be extinguished using a cue-exposure paradigm. Rats received 18 N2O administrations in a total calorimetry system that simulta...
Repeated nitrous oxide exposure in rats causes a thermoregulatory sign-reversal with concurrent activation of opposing thermoregulatory effectors [0.03%]
重复暴露一氧化二氮可导致大鼠出现体温调节反应倒置并同时激活对立的体温调节效应器
Douglas S Ramsay,Stephen C Woods,Karl J Kaiyala
Douglas S Ramsay
Initial administration of 60% nitrous oxide (N2O) to rats at an ambient temperature of 21°C decreases core temperature (Tc), primarily via increased heat loss (HL). Over repeated N2O administrations, rats first develop tolerance to this hy...
Drug-induced regulatory overcompensation has motivational consequences: Implications for homeostatic and allostatic models of drug addiction [0.03%]
药物引起的调节过度补偿具有动机后果：对药物成瘾的稳态和代偿模型的影响
Douglas S Ramsay,Stephen C Woods,Karl J Kaiyala
Douglas S Ramsay
Initial administration of 60% nitrous oxide (N2O) at 21°C ambient temperature (Ta) reduces core temperature (Tc) in rats, but tolerance develops to this hypothermic effect over several administrations. After additional N2O administrations,...