Susie Kim,Kelsey Steffen,Lauren Gottschalk-Henneberry et al.
Susie Kim et al.
Objective: Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outco...
Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21-Year Period [0.03%]
特发性震颤患者浦肯野细胞丢失：来自215名患者大脑的21年汇总数据
Chloë A Kerridge,Roberto S Hernandez,Nora C Hernandez et al.
Chloë A Kerridge et al.
Objective: Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations. Postmortem studies have v...
Wenci Yan,Terence Quinn,Alex McConnachie et al.
Wenci Yan et al.
Objective: Cognitive decline can occur following ischaemic stroke. How cognition changes over time and associations with cognitive change are poorly understood. This study aimed to explore these issues over 2 years follow...
A Multi-Center Retrospective Cohort Study of Neurosarcoidosis Myelitis: Current Observations and Future Directions [0.03%]
多中心神经囊性病脊髓炎回顾队列研究：当前观察和未来方向
Giovanna S Manzano,Denis Balaban,Yihan Zhang et al.
Giovanna S Manzano et al.
Objective: The optimal treatment for neurosarcoidosis myelitis is uncertain. We characterize incident neurosarcoidosis myelitis and assess treatment response by MRI and clinical scales. ...
Frequency of Seroconversion in Aquaporin-4 Antibody Testing: Insights From Real-World Data [0.03%]
Aquaporin-4抗体检测中的假阳性率分析：基于真实世界数据的见解
Tatchaporn Ongphichetmetha,Mengke Du,Nisa Vorasoot et al.
Tatchaporn Ongphichetmetha et al.
Clinicians often repeat aquaporin-4-immunoglobulin G (AQP4-IgG) testing in case of possible seroconversion. Compared with older, less sensitive immunofluorescence assays (IFA), cell-based assays (CBA) offer higher sensitivity. This study as...
Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers [0.03%]
携带GRN致病突变的个体中与疾病进展标志物相关的功能连接性
Taru M Flagan,Stephanie A Chu,Suvi Häkkinen et al.
Taru M Flagan et al.
Objective: Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN-related therapies are underway, there is an unmet need for bioma...
Exploring Nasal Structural-Microbial Interactions in Multiple Sclerosis-Associated Olfactory Impairment [0.03%]
多发性硬化相关嗅觉障碍的鼻腔结构-微生物相互作用研究
Zidan Gao,Zhuoma Danzhen,Yao Li et al.
Zidan Gao et al.
Background: Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal ...
Functional Characterization and Pathogenicity Classification of PRRT2 Splice Variants in PRRT2-Related Disorders [0.03%]
PRRT2相关疾病中PRRT2剪接变异体的功能表征和致病性分类
Jiao-Jiao Xu,Yu-Lan Chen,Wan-Bing Sun et al.
Jiao-Jiao Xu et al.
Objective: Paroxysmal kinesigenic dyskinesia (PKD) is the most common hereditary paroxysmal movement disorder. The PRRT2 gene is the first identified causative gene and accounts for the majority of PKD. In this study, we ...
The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study [0.03%]
慢性活动性病灶与白质病变的相关性：一项7特斯拉磁共振成像研究
Ellie McCluey,Ahmad A Toubasi,Jiacheng Wang et al.
Ellie McCluey et al.
Background: The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, ...