Durable B-Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis [0.03%]
奥扎莫德治疗多发性硬化症患者的B细胞持久损伤，而IgA B细胞不受影响
Alexandra Garcia,Stephane Rodriguez,Emilie Dugast et al.
Alexandra Garcia et al.
Objectives: Ocrelizumab (OCR), a humanized anti-CD20 monoclonal antibody, is highly efficient in relapsing-remitting multiple sclerosis (RR-MS). We assessed early cellular B-cell profiles in patients prior to OCR treatmen...
Reply to Letter: "Real-World Clinical Experience With Serum MOG and AQP4 Antibody Testing by Live Versus Fixed Cell-Based Assay" [0.03%]
莫甘氏抗体和AQP4-IgG检测的固定细胞与活细胞基底法临床经验来信回复
Yana Said,Eoin P Flanagan,Elias S Sotirchos
Yana Said
Giulio Degano,Hervé Quintard,Andreas Kleinschmidt et al.
Giulio Degano et al.
Objective: Patients in the intensive care unit (ICU) often require continuous EEG (cEEG) monitoring due to the high risk of seizures and rhythmic and periodic patterns (RPPs). However, interpreting cEEG in real time is re...
Exploring if Longitudinal Changes on PET Imaging Can Serve as a Biomarker for Stiff Person Syndrome Spectrum Disorders [0.03%]
探究PET影像纵向变化是否可作为僵人综合征谱系障碍生物标志物
Munther M Queisi,Samantha N Roman,Mohammad S Sadaghiani et al.
Munther M Queisi et al.
Objective: To identify metabolic patterns in the brain and musculoskeletal system of stiff person syndrome spectrum disorders (SPSD) patients over time using PET imaging and evaluate the impact of immune therapy on metabo...
Translating a Preclinically Tested 15 Hz rTMS Protocol to Humans With Chronic Spinal Cord Injury: A Safety and Feasibility Study [0.03%]
慢性脊髓损伤患者经临床前测试的15赫兹rTMS方案的人体试验：一项安全性和可行性研究
Nabila Brihmat,Mehmed B Bayram,Morgan Paine et al.
Nabila Brihmat et al.
Objectives: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation strategy with a demonstrated potential to reinforce the residual pathways after a spinal cord injury (SCI). A preclinical...
Long-Term Temporal Profile of Motor Recovery After Intracerebral Hemorrhage [0.03%]
脑出血后的长期运动恢复时间过程特征研究
Yan Zheng,Fu-Xin Lin,Ling-Yun Zhuo et al.
Yan Zheng et al.
Objective: Limited data is available to describe the temporal profile of long-term recovery over 1 year after the stroke in patients with spontaneous intracerebral hemorrhage (ICH). ...
The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis [0.03%]
风险等位基因rs10191329与多发性硬化视网膜层萎缩相关
Gabriel Bsteh,Ruchi Tanavade,Nik Krajnc et al.
Gabriel Bsteh et al.
Objective: To investigate whether the rs10191329 risk allele in the DYSF-ZNF638 locus, which is implicated in central nervous system resilience rather than immune-mediated pathology, is associated with retinal layer thinn...
Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age- and BMI-Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response [0.03%]
核磁轻链在多发性硬化症中的作用：年龄和BMI校正的Z分数/百分位数优于绝对截止值预测治疗反应优势
Maximilian Einsiedler,Aleksandra Maleska Maceski,Sofia Sandgren et al.
Maximilian Einsiedler et al.
Objective: Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age- and BMI-adjusted) wit...
Itay Tokatly Latzer,Henry H C Lee,Edward Yang et al.
Itay Tokatly Latzer et al.
Objectives: Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ-aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotra...
Medication Use in Multiple Sclerosis: A Population-Based Comparison With the General Danish Population [0.03%]
丹麦多发性硬化症患者用药情况调查：与一般丹麦人口的对比研究
Josefine Windfeld-Mathiasen,Henrik Horwitz,Ida M Heerfordt et al.
Josefine Windfeld-Mathiasen et al.
Objective: To investigate the overall use of prescription medications among individuals with multiple sclerosis compared to the general population, with a focus on treatments beyond disease-modifying therapies. ...