A Validated Model to Predict Severe Weight Loss in Amyotrophic Lateral Sclerosis [0.03%]
一个预测肌萎缩侧索硬化症严重体重下降的验证模型
David G Lester,Kevin Talbot,Martin R Turner et al.
David G Lester et al.
Severe weight loss in amyotrophic lateral sclerosis (ALS) is common, multifactorial, and associated with shortened survival. Using longitudinal weight data from over 6000 patients with ALS across three cohorts, we built an accelerated failu...
Single-Cell RNA Seq in Sydenham Chorea Shows B Cell HLA-DR/DQ Upregulation and Plasma Cell Proteasomal Activation [0.03%]
单细胞RNA测序显示风湿性舞蹈病中B细胞HLA-DR / DQ上调和浆细胞蛋白酶体活化
Velda X Han,Brooke A Keating,Brian S Gloss et al.
Velda X Han et al.
The pathogenesis of Sydenham chorea remains unclear. We report a 10-year-old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single-cell RNA sequencing on 30,794 peripheral immune cells from ...
Durability of Response to B-Cell Maturation Antigen-Directed mRNA Cell Therapy in Myasthenia Gravis [0.03%]
靶向B细胞成熟抗原信息 RNA 细胞治疗肌无力的疗效持续性评估结果
Nizar Chahin,Gregory Sahagian,Marc H Feinberg et al.
Nizar Chahin et al.
Objective: We report the 12-month follow-up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes-08, a BCMA-directed RNA chimeric antigen receptor T-cell (rCAR-T) therapy for refractory generalized my...
SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High-Grade Gliomas: A Multicenter, Open-Label Phase I Study [0.03%]
一项关于SYHA1813（一种VEGFR和CSF1R抑制剂）治疗复发性高级别胶质瘤患者的多中心开放标签I期临床研究
Zhuang Kang,Shenglan Li,Liang Wang et al.
Zhuang Kang et al.
Objective: Recurrent high-grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurr...
Long-Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons [0.03%]
长期评估givinostat治疗杜氏肌营养不良的疗效及其自然病史的对比研究
Craig M McDonald,Michela Guglieri,Dragana Vučinić et al.
Craig M McDonald et al.
Objectives: This ongoing, open-label extension study is evaluating the long-term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrop...
Quantitative Iron Measurements in the Basal Ganglia of NBIA Patients Using QSM: Insights From a Tertiary Center [0.03%]
三级医疗中心NBIA患者基底节定量铁含量测量（使用QSM）的启示
Özge Uygun,Alpay Özcan,Fuat Kaan Aras et al.
Özge Uygun et al.
Objective: Neurodegeneration with brain iron accumulation (NBIA) comprises rare genetic disorders characterized by predominantly extrapyramidal symptoms and iron deposition in the basal ganglia. Conventional magnetic reso...
Mechanical Thrombectomy for TRACE-III-Eligible Patients With Ischemic Stroke: A Multicenter Retrospective Study Compared to TRACE-III and TIMELESS Trials [0.03%]
针对符合TRACE-III标准的缺血性卒中患者进行机械取栓的多中心回顾性研究：与TRACE-III和TIMELESS试验结果对比
Chongyang Huang,Yanru Liu,Jiangang Zhang et al.
Chongyang Huang et al.
Objective: The results of the TRACE-III trial demonstrated that tenecteplase (TNK) might be comparable to TNK combined with mechanical thrombectomy (MT) for large vessel occlusion (LVO) stroke within 4.5 to 24 h of onset,...
Bilateral versus Unilateral Training With Rhythmic Auditory Cueing in Stroke Rehabilitation: Effects on Upper Limb Function and Interhemispheric Inhibition [0.03%]
节奏听觉提示下的卒中康复中的双侧和单侧训练对上肢功能及半球间抑制的影响
Fangfang Qian,Yanhong Dai,Guoqiang Zheng et al.
Fangfang Qian et al.
Background: Stroke is a leading cause of long-term disability in adults, with upper limb hemiparesis being a common impairment. Traditional training is mostly aimed at paralyzed limbs, but the effect of bilateral training...
Effects of Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs on Acute Intracerebral Hemorrhage [0.03%]
非阿司匹林非甾体抗炎药与急性脑出血的关系
Shin-Joe Yeh,Sung-Chun Tang,Li-Kai Tsai et al.
Shin-Joe Yeh et al.
Objective: Despite celecoxib, a cyclooxygenase-2 inhibitor, promoting functional recovery from intracerebral hemorrhage (ICH) by reducing inflammation-mediated perihematomal edema in rat models, the evidence of its effect...
Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis [0.03%]
LGI1自身免疫性脑炎中的细胞因子、趋化因子和神经丝轻链标志物分析
Albert Aboseif,Georgios Mangioris,Binxia Yang et al.
Albert Aboseif et al.
Objectives: To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE)....