Quantity and Volume of Perivascular Spaces Are Inversely Associated With Multiple Sclerosis Relative to Cerebrovascular Disease and Migraine [0.03%]
血管周围间隙的数量和体积与多发性硬化症的关系独立于脑血管疾病和偏头痛而存在负相关关系
Elle M Levit,Elizabeth A Horwath,Daniel L Schwartz et al.
Elle M Levit et al.
Objective: To quantify the number and volume of whole brain perivascular spaces (PVS) using a detection and segmentation algorithm in participants with multiple sclerosis (MS) and patients with disorders mimicking MS know...
Dallah Yoo,Jeong-Yong Shin,Rugyeom Lee et al.
Dallah Yoo et al.
Objectives: Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by the progressive narrowing of arteries at the base of the brain, forming abnormal collateral vascular networks. While vascular parkinso...
Prevalence of Stroke and Diagnostic Performance of Emergency MRI in Acute Isolated Dizziness [0.03%]
急性孤立性头晕的卒中患病率及急诊磁共振诊断价值研究
Xiao Hu,Sijia Liu,Xiaosan Wu et al.
Xiao Hu et al.
Objective: Stroke is frequently misdiagnosed in patients presenting with acute isolated dizziness; the optimal imaging modality for this population remains debated. This study aimed to determine the prevalence of stroke a...
Assessing a Mitochondrial Disease Treatment via a Novel Statistical Technique for Accelerometer Data [0.03%]
一种评估线粒体疾病治疗方法的新统计技术及其在加速计数据中的应用
Ian W McKeague,Kristin Engelstad,Yue Ge et al.
Ian W McKeague et al.
Objective: Therapeutic development for mitochondrial diseases, rare genetic disorders with pathogenic defects of oxidative phosphorylation, is hindered by unsatisfactory outcome measures. To address this problem, we provi...
Plasma p-tau181 as a Marker of Conversion to Alzheimer's Disease Dementia and Worsening in Cognitive Functions in Subjective Cognitive Decline and Mild Cognitive Impairment: A Longitudinal Study [0.03%]
血浆p-tau181是主观认知下降和轻度认知障碍向阿尔茨海默病痴呆转化及认知功能恶化的标志：一项纵向研究
Giulia Giacomucci,Assunta Ingannato,Chiara Crucitti et al.
Giulia Giacomucci et al.
Background: Plasma p-tau181 has proven to be a promising diagnostic and prognostic tool in the earliest phases of Alzheimer's disease (AD). We aimed to evaluate the prognostic role of p-tau181 in predicting conversion to ...
Matthew J Kmiecik,Michael V Holmes,Pierre Fontanillas et al.
Matthew J Kmiecik et al.
Objective: To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Met...
Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72 [0.03%]
C9orf72基因携带者和肌萎缩侧索硬化患者的神经兴奋性
Diederik J L Stikvoort García,H Stephan Goedee,Leonard H van den Berg et al.
Diederik J L Stikvoort García et al.
Objective: We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients....
Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease [0.03%]
Wilson病患者血浆酸性神经胶质纤维蛋白水平与脑金属沉积负荷的相关性研究
Sung-Pin Fan,Ya-Fang Chen,Cheng-Hsuan Li et al.
Sung-Pin Fan et al.
Objective: Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation mar...
Analysis of Soluble Interleukin-2 Receptor as a Prognostic Biomarker in NMOSD and MOGAD [0.03%]
soluble interleukin-2 receptor作为NMOSD和MOGAD预后生物标志物的分析
Philipp Klyscz,Carolin Otto,Klemens Ruprecht et al.
Philipp Klyscz et al.
Objective: Soluble interleukin-2 receptor (sIL-2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated di...
Long COVID in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross-Sectional Study [0.03%]
多发性硬化等疾病患者中的长新冠：一项多中心横断面研究
Chen Hu,Jiyeon Son,Lindsay McAlpine et al.
Chen Hu et al.
Background: Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus co...