The McCance Brain Care Score and Mortality: Evidence From a Large-Scale Population-Based Cohort [0.03%]
麦肯茨大脑护理评分与死亡率：来自大规模人群队列的证据
Zhiqiang Xu,Xiaoxiao Wang,Nan Li
Zhiqiang Xu
Objectives: This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods: ...
Increased Blood Levels of NfL, GFAP, and Placental Growth Factor After Radiotherapy to the Brain [0.03%]
头部放射治疗后血浆神经元损伤和星形胶质细胞活化生物标志物水平升高
Erik Fernström,Thomas Björk-Eriksson,Pontus Erickson et al.
Erik Fernström et al.
In this study, we analyzed biomarkers of neuronal, glial, and vascular injury in longitudinal paired samples of blood and cerebrospinal fluid after prophylactic cranial irradiation in patients with small cell lung cancer. Neurofilament ligh...
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease [0.03%]
发现和靶向蛋白组学研究揭示经验证的亨廷顿舞蹈病纹状体标志物
Daniel Chelsky,Cara Joyce,H Jeremy Bockholt et al.
Daniel Chelsky et al.
Objective: Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examina...
Lessons Learned From a Delayed-Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease [0.03%]
关于普拉克索治疗帕金森病冻结步态延迟启动试验的经验教训
Tuhin Virmani,Lakshmi Pillai,Reid D Landes et al.
Tuhin Virmani et al.
Objective: Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep bra...
Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay in Two Half-Siblings [0.03%]
查尔列弗瓦-萨格奈_autosomal_隐性遗传脊髓小脑性共济失调两例半同胞兄妹
Dennis Yeow,Matthew Katz,Jonathan Rodgers et al.
Dennis Yeow et al.
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is caused by biallelic pathogenic variants in the SACS gene. We report the clinical, radiologic and neurophysiologic features of a pair of half-siblings who presented with p...
Vrishab Commuri,Isabella Dallasta,Ciaran Stone et al.
Vrishab Commuri et al.
Objective: Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this st...
Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG-IgG Dual Seropositive: A Case Report [0.03%]
_satralizumab治疗AQP4/MOG-IgG双阳性的视神经脊髓炎谱系病合并妊娠1例_
Yeting Luo,Shuhua Xie,Xianghong Liu
Yeting Luo
Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4-IgG) or myelin oligodendrocyte glycoprotein (MOG-IgG). Simultaneous seropositi...
Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review [0.03%]
脊髓性肌萎缩症患者使用nusinersen和risdiplam的疗效与安全性系统评价
Amin Mehrabian,Peter Auguste,Amy Grove et al.
Amin Mehrabian et al.
Objective: Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring co...
Refractory Status Epilepticus Treated With Bilateral Pulvinar Deep Brain Stimulation-A Case Study [0.03%]
用于治疗难治性状态性癫痫的双侧脑回深部电刺激术——一例研究
Mengxuan Tang,Amerta Bai,Felipe Rodridgues Marques Ferreira et al.
Mengxuan Tang et al.
New-onset refractory status epilepticus (NORSE) arises without an identifiable cause or prior epilepsy history, with a 16%-27% mortality rate and significant long-term neurological sequelae. Neuromodulation such as deep brain stimulation (D...
Age-Related Characteristics of SYT1-Associated Neurodevelopmental Disorder [0.03%]
与SYT1相关的神经发育障碍的年龄特征
Sam G Norwitz,Josefine Eck,Joel S Winston et al.
Sam G Norwitz et al.
Objectives: We describe the clinical manifestations and developmental abilities of individuals with SYT1-associated neurodevelopmental disorder (Baker-Gordon syndrome) from infancy to adulthood. We further describe the ne...