Chemical Composition and Biological Activities of Lebanese Pentapera Plant [0.03%]
黎巴嫩五翅果属植物的化学成分及生物活性研究
Hany Kallassy,Hussein Fayyad-Kazan,Rawan Makki et al.
Hany Kallassy et al.
BACKGROUND Due to their chemical constituents and biological properties, plants have long been used to control life-threatening diseases. The flora of Lebanon includes many plants that have already been demonstrated to have medicinal value,...
New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System [0.03%]
子宫肌瘤发病新机制：内源大麻素系统的作用及其意义
Thangesweran Ayakannu,Anthony H Taylor,Timothy H Marczylo et al.
Thangesweran Ayakannu et al.
BACKGROUND The aim of this study was to determine if components of the endocannabinoid system are modulated in uterine leiomyomas (fibroids). Components studied included cannabinoid receptors 1 (CB1) and 2 (CB2); the G protein-coupled recep...
Rosmarinic Acid Analogue-11 Induces Apoptosis of Human Gastric Cancer SGC-7901 Cells via the Epidermal Growth Factor Receptor (EGFR)/Akt/Nuclear Factor kappa B (NF-κB) Pathway [0.03%]
鼠李糖酸类似物-11通过表皮生长因子受体(Akt/NF-κB)信号途径诱导人胃癌SGC-7901细胞凋亡
Wanting Li,Qing Li,Liqun Wei et al.
Wanting Li et al.
BACKGROUND According to the latest statistics from the American Cancer Society, there will be 1.73 million cancer cases and more than 600 000 cancer deaths in the United States in 2018, among which there will be 26 240 new cases of gastric ...
miR-193a-3p Promotes Radio-Resistance of Nasopharyngeal Cancer Cells by Targeting SRSF2 Gene and Hypoxia Signaling Pathway [0.03%]
microRNA-193a-3p通过靶向SRSF2基因及低氧信号通路促进鼻咽癌细胞的放射抵抗性
Lingsuo Kong,Qing Wei,Xianwen Hu et al.
Lingsuo Kong et al.
BACKGROUND Radio-resistance is an important barrier in nasopharyngeal carcinoma treatment. MicroRNAs are gene expression core regulators in various biological procedures containing cancer radio-resistance. Nevertheless, the clinical associa...
Escherichia Coli Outer Membrane Vesicles Induced DNA Double-Strand Breaks in Intestinal Epithelial Caco-2 Cells [0.03%]
大肠埃希氏菌外膜囊泡诱导Caco-2细胞DNA双链断裂
Zhou Ling,Chen Dayong,Yu Denggao et al.
Zhou Ling et al.
BACKGROUND Recent studies have shown that Escherichia coli induced digestive tract diseases may be related to outer membrane vesicles (OMVs) induced intestinal double-strand breaks (DSBs) in intestinal epithelial cells. This study aimed to ...
Autophagy and Oncosis/Necroptosis Are Enhanced in Cardiomyocytes from Heart Failure Patients [0.03%]
心力衰竭患者心脏中自噬和细胞坏死增加
Giovanni Corsetti,Carol Chen-Scarabelli,Claudia Romano et al.
Giovanni Corsetti et al.
BACKGROUND Although originally described as a survival mechanism, it is unknown whether and to what extent autophagy is implicated in the terminal stages of heart failure. Here, we studied magnitude and evolution of autophagy in patients wi...
Effects of Electroacupuncture on Expression of D1 Receptor (D1R), Phosphorylation of Extracellular-Regulated Protein Kinase 1/2 (p-ERK1/2), and c-Fos in the Insular Cortex of Ketamine-Addicted Rats [0.03%]
电针百会和内关对氯胺酮成瘾大鼠脑岛区D1受体、p-ERK1/2及c-Fos表达的影响
Feng Wu,Jian Ding,Huai-Bin Li et al.
Feng Wu et al.
BACKGROUND The aim of this study was to investigate the effects of electroacupuncture (EA) on expression of the D1 receptor (D1R), phosphorylation of extracellular-regulated protein kinase 1/2 (p-ERK1/2) and c-Fos in the insular cortex (IC)...
G-Protein-Coupled Receptor 5 (LGR5) Overexpression Activates β-Catenin Signaling in Breast Cancer Cells via Protein Kinase A [0.03%]
G蛋白偶联受体5(LGR5)过表达通过蛋白激酶A活化乳腺癌细胞中的β-连环素信号通路
Zhishui Chen,Chengjun Xue
Zhishui Chen
BACKGROUND Targeting cancer stem cells (CSCs) in breast cancer (BrCa) may improve treatment outcome and patient prognosis. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a well-recognized adult stem cell and CRC marke...
Augmentation of Whole-Body Metabolic Status by Mind-Body Training: Synchronous Integration of Tissue- and Organ-Specific Mitochondrial Function [0.03%]
意念身体训练增强全身代谢状态：组织和器官特异性的线粒体功能的同步整合
George B Stefano,Tobias Esch,Richard M Kream
George B Stefano
The objective of our concise review is to elaborate an evidence-based integrative medicine model that incorporates functional linkages of key aspects of cortically-driven mind-body training procedures to biochemical and molecular processes ...
Need for Intervention Services for Promotion of Condom Use by Female Sex Workers to Consider Size of Entertainment Venues: A Cross-Sectional Study [0.03%]
一项横断面研究：提供干预服务以促进娱乐场所女性性工作者使用避孕套应考虑其规模和地区分布
Baifeng Chen,Jian Chen,Yinbao Shao et al.
Baifeng Chen et al.
BACKGROUND Consistent condom use among female sex workers (FSWs) is a key intervention in China's AIDS Control Program. Female sex workers (FSWs) in China are at increased risk for acquiring HIV/AIDS because of low knowledge about HIV trans...