Bruno Manta,Dana Boyd,Mehmet Berkmen
Bruno Manta
The formation of disulfide bonds is critical to the folding of many extracytoplasmic proteins in all domains of life. With the discovery in the early 1990s that disulfide bond formation is catalyzed by enzymes, the field of oxidative foldin...
Mechanisms of Type I-E and I-F CRISPR-Cas Systems in Enterobacteriaceae [0.03%]
肠杆菌科I-E和I-F型CRISPR-Cas系统的机制研究
Chaoyou Xue,Dipali G Sashital
Chaoyou Xue
CRISPR-Cas systems provide bacteria and archaea with adaptive immunity against invasion by bacteriophages and other mobile genetic elements. Short fragments of invader DNA are stored as immunological memories within CRISPR (clustered regula...
Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target [0.03%]
III型分泌系统注射装置作为反病毒靶标的 promise 与挑战
Alyssa C Fasciano,Lamyaa Shaban,Joan Mecsas
Alyssa C Fasciano
Antibiotic resistance is a major public health threat that has stimulated the scientific community to search for nontraditional therapeutic targets. Because virulence, but not the growth, of many Gram-negative bacterial pathogens depends on...
Similarities and Differences between Colicin and Filamentous Phage Uptake by Bacterial Cells [0.03%]
关于细菌细胞对coli素和丝状噬菌体摄取的异同点分析
Denis Duché,Laetitia Houot
Denis Duché
Gram-negative bacteria have evolved a complex envelope to adapt and survive in a broad range of ecological niches. This physical barrier is the first line of defense against noxious compounds and viral particles called bacteriophages. Colic...
James J Gilchrist,Calman A MacLennan
James J Gilchrist
Nontyphoidal salmonellae (NTS) are a major cause of invasive (iNTS) disease in sub-Saharan Africa, manifesting as bacteremia and meningitis. Available epidemiological data indicate that iNTS disease is endemic in much of the region. Antimic...
Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation [0.03%]
氨基糖苷类抗生素的复兴：一类历久弥新的抗菌药的回顾
Alisa W Serio,Tiffany Keepers,Logan Andrews et al.
Alisa W Serio et al.
Aminoglycosides are cidal inhibitors of bacterial protein synthesis that have been utilized for the treatment of serious bacterial infections for almost 80 years. There have been approximately 15 members of this class approved worldwide for...
The EcoCyc Database [0.03%]
EcoCyc数据库
Peter D Karp,Wai Kit Ong,Suzanne Paley et al.
Peter D Karp et al.
EcoCyc is a bioinformatics database available at EcoCyc.org that describes the genome and the biochemical machinery of Escherichia coli K-12 MG1655. The long-term goal of the project is to describe the complete molecular catalog of the E. c...
An Introduction to the Structure and Function of the Catalytic Core Enzyme of Escherichia coli RNA Polymerase [0.03%]
大肠杆菌RNA聚合酶核心酶催化亚基的结构与功能介绍
Catherine Sutherland,Katsuhiko S Murakami
Catherine Sutherland
RNA polymerase (RNAP) is the essential enzyme responsible for transcribing genetic information stored in DNA to RNA. Understanding the structure and function of RNAP is important for those who study basic principles in gene expression, such...
Blake Bertani,Natividad Ruiz
Blake Bertani
The cell envelope is the first line of defense between a bacterium and the world-at-large. Often, the initial steps that determine the outcome of chemical warfare, bacteriophage infections, and battles with other bacteria or the immune syst...
Spread and Persistence of Virulence and Antibiotic Resistance Genes: A Ride on the F Plasmid Conjugation Module [0.03%]
毒力基因和抗生素抗性基因的传播与持久性：搭乘F质粒接合模块穿梭
Günther Koraimann
Günther Koraimann
The F plasmid or F-factor is a large, 100-kbp, circular conjugative plasmid of Escherichia coli and was originally described as a vector for horizontal gene transfer and gene recombination in the late 1940s. Since then, F and related F-like...