Kelly M Frain,Jan Maarten van Dijl,Colin Robinson
Kelly M Frain
The Tat pathway for protein translocation across bacterial membranes stands out for its selective handling of fully folded cargo proteins. In this review, we provide a comprehensive summary of our current understanding of the different know...
Jean-Yves Bouet,Barbara E Funnell
Jean-Yves Bouet
Plasmids are ubiquitous in the microbial world and have been identified in almost all species of bacteria that have been examined. Their localization inside the bacterial cell has been examined for about two decades; typically, they are not...
The Injectisome, a Complex Nanomachine for Protein Injection into Mammalian Cells [0.03%]
用于向哺乳动物细胞注射蛋白质的复杂纳米机器注入素
Maria Lara-Tejero,Jorge E Galán
Maria Lara-Tejero
Type III protein secretion systems (T3SSs), or injectisomes, are multiprotein nanomachines present in many Gram-negative bacteria that have a sustained long-standing close relationship with a eukaryotic host. These secretion systems have ev...
Marcin Grabowicz
Marcin Grabowicz
Lipoproteins are produced by both Gram-positive and Gram-negative bacteria. Once secreted, lipoproteins are quickly acylated, anchoring them into the plasma membrane. Recent work has shown that Gram-positive bacteria are able to generate co...
Curli Biogenesis: Bacterial Amyloid Assembly by the Type VIII Secretion Pathway [0.03%]
卷宗生物发生：通过8型分泌途径生成细菌淀粉样蛋白
Sujeet Bhoite,Nani van Gerven,Matthew R Chapman et al.
Sujeet Bhoite et al.
In 1989, Normark and coworkers reported on fibrous surface structures called curli on strains of Escherichia coli that were suspected of causing bovine mastitis. Subsequent work by many groups has revealed an elegant and highly regulated cu...
Therapeutic Approaches Targeting the Assembly and Function of Chaperone-Usher Pili [0.03%]
针对伴侣-switch型菌毛装配和功能的治疗手段
John J Psonis,David G Thanassi
John J Psonis
The chaperone-usher (CU) pathway is a conserved secretion system dedicated to the assembly of a superfamily of virulence-associated surface structures by a wide range of Gram-negative bacteria. Pilus biogenesis by the CU pathway requires tw...
Dante P Ricci,Thomas J Silhavy
Dante P Ricci
Like all outer membrane (OM) constituents, integral OM β-barrel proteins in Gram-negative bacteria are synthesized in the cytoplasm and trafficked to the OM, where they are locally assembled into the growing OM by the ubiquitous β-barrel ...
Harris D Bernstein
Harris D Bernstein
Type V, or "autotransporter," secretion is a term used to refer to several simple protein export pathways that are found in a wide range of Gram-negative bacteria. Autotransporters are generally single polypeptides that consist of an extrac...
The TAM: A Translocation and Assembly Module of the β-Barrel Assembly Machinery in Bacterial Outer Membranes [0.03%]
β-桶状装配机器在细菌外膜中的转位和组装模块(TAM)
Christopher J Stubenrauch,Trevor Lithgow
Christopher J Stubenrauch
Assembly of proteins into the outer membrane is an essential process in the cell biology of bacteria. The integration of β-barrel proteins into the outer membrane is mediated by a system referred to as the β-barrel assembly machinery (BAM...
Konstantin V Korotkov,Maria Sandkvist
Konstantin V Korotkov
The type II secretion system (T2SS) delivers toxins and a range of hydrolytic enzymes, including proteases, lipases, and carbohydrate-active enzymes, to the cell surface or extracellular space of Gram-negative bacteria. Its contribution to ...