Gwanggyu Sun,Travis A Ahn-Horst,Markus W Covert
Gwanggyu Sun
The Escherichia coli whole-cell modeling project seeks to create the most detailed computational model of an E. coli cell in order to better understand and predict the behavior of this model organism. Details about the approach, framework, ...
Repurposing CRISPR-Cas Systems as Genetic Tools for the Enterobacteriales [0.03%]
CRISPR-Cas系统在肠杆菌科中的基因工具再利用
Nicholas Backes,Gregory J Phillips
Nicholas Backes
Over the last decade, the study of CRISPR-Cas systems has progressed from a newly discovered bacterial defense mechanism to a diverse suite of genetic tools that have been applied across all domains of life. While the initial applications o...
Eric W Brown,Rebecca Bell,Guodong Zhang et al.
Eric W Brown et al.
The species Salmonella enterica comprises over 2,600 serovars, many of which are known to be intracellular pathogens of mammals, birds, and reptiles. It is now apparent that Salmonella is a highly adapted environmental microbe and can readi...
Copper Homeostatic Mechanisms and Their Role in the Virulence of Escherichia coli and Salmonella enterica [0.03%]
铜的稳态机制及其在大肠杆菌和沙门氏菌毒力中的作用
Amanda Hyre,Kaitlin Casanova-Hampton,Sargurunathan Subashchandrabose
Amanda Hyre
Copper is an essential micronutrient that also exerts toxic effects at high concentrations. This review summarizes the current state of knowledge on copper handling and homeostasis systems in Escherichia coli and Salmonella enterica. We des...
Maxime Leroux,Nicolas Soubry,Rodrigo Reyes-Lamothe
Maxime Leroux
Proteins are major contributors to the composition and the functions in the cell. They often assemble into larger structures, macromolecular machines, to carry out intricate essential functions. Although huge progress in understanding how m...
Angela Tramonti,Caterina Nardella,Martino L di Salvo et al.
Angela Tramonti et al.
Vitamin B6 is an ensemble of six interconvertible vitamers: pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL), and their 5'-phosphate derivatives, PNP, PMP, and PLP. Pyridoxal 5'-phosphate is a coenzyme in a variety of enzyme reactions con...
Nicholas Waglechner,Elizabeth J Culp,Gerard D Wright
Nicholas Waglechner
As the spread of antibiotic resistance threatens our ability to treat infections, avoiding the return of a preantibiotic era requires the discovery of new drugs. While therapeutic use of antibiotics followed by the inevitable selection of r...
Role of Plasmids in the Ecology and Evolution of "High-Risk" Extraintestinal Pathogenic Escherichia coli Clones [0.03%]
关于“高风险”肠外病原性大肠杆菌菌株的生态和进化中的质粒作用
Timothy J Johnson
Timothy J Johnson
Bacterial plasmids have been linked to virulence in Escherichia coli and Salmonella since their initial discovery. Though the plasmid repertoire of these bacterial species is extremely diverse, virulence-associated attributes tend to be lim...
Shambhavi Garde,Pavan Kumar Chodisetti,Manjula Reddy
Shambhavi Garde
Peptidoglycan is a defining feature of the bacterial cell wall. Initially identified as a target of the revolutionary beta-lactam antibiotics, peptidoglycan has become a subject of much interest for its biology, its potential for the discov...
Mechanisms of Theta Plasmid Replication in Enterobacteria and Implications for Adaptation to Its Host [0.03%]
大肠杆菌θ质粒的复制机制及其对宿主适应性的影响研究
Jay W Kim,Vega Bugata,Gerardo Cortés-Cortés et al.
Jay W Kim et al.
Plasmids are autonomously replicating sequences that help cells adapt to diverse stresses. Theta plasmids are the most frequent plasmid class in enterobacteria. They co-opt two host replication mechanisms: replication at oriC, a DnaA-depend...