Peter D Karp,Suzanne Paley,Ron Caspi et al.
Peter D Karp et al.
EcoCyc is a bioinformatics database (DB) available at EcoCyc.org that describes the genome and the biochemical machinery of Escherichia coli K-12 MG1655. The long-term goal of the project was to describe the complete molecular catalog of th...
The E. coli CRISPR-Cas conundrum: are they functional immune systems or genomic singularities? [0.03%]
大肠杆菌CRISPR-Cas悖论：它们是功能性的免疫系统还是基因组奇观？
Edward G Dudley
Edward G Dudley
The discovery and subsequent characterization and applications of CRISPR-Cas is one of the most fascinating scientific stories from the past two decades. While first identified in Escherichia coli, this microbial workhorse often took a back...
Malcolm G P Page
Malcolm G P Page
Siderophore cephalosporins are designed to exploit bacterial nutrient uptake systems to gain accelerated uptake across the outer membrane of Gram-negative bacteria. They contain iron (III) binding motifs that allow them to form complexes th...
The rise, fall, and resurgence of phage therapy for urinary tract infection [0.03%]
噬菌体治疗尿路感染的兴起、衰落与复兴
Jacob J Zulk,Kathryn A Patras,Anthony W Maresso
Jacob J Zulk
In the face of rising antimicrobial resistance, bacteriophage therapy, also known as phage therapy, is seeing a resurgence as a potential treatment for bacterial infections including urinary tract infection (UTI). Primarily caused by uropat...
Dale E A Lewis,Sankar Adhya
Dale E A Lewis
Bacteriophage λ is a paradigm in the field of gene regulation and one of the best-understood systems in genetic regulatory biology. A so-called Genetic Switch determines the mechanisms by which λ transitions to its dual lifestyles-lytic o...
Genetic engineering of Salmonella spp. for novel vaccine strategies and therapeutics [0.03%]
基因工程沙门菌新疫苗和治疗策略遗传工程研究进展
Garima Bansal,Mostafa Ghanem,Khandra T Sears et al.
Garima Bansal et al.
Salmonella enterica is a diverse species that infects both humans and animals. S. enterica subspecies enterica consists of more than 1,500 serovars. Unlike typhoidal Salmonella serovars which are human host-restricted, non-typhoidal Salmone...
Spatio-temporal organization of the E. coli chromosome from base to cellular length scales [0.03%]
从碱基到细胞长度尺度的E.coli染色体时空组织
Sonya K Royzenblat,Lydia Freddolino
Sonya K Royzenblat
Escherichia coli has been a vital model organism for studying chromosomal structure, thanks, in part, to its small and circular genome (4.6 million base pairs) and well-characterized biochemical pathways. Over the last several decades, we h...
Type I toxin-antitoxin systems in bacteria: from regulation to biological functions [0.03%]
细菌I型毒素-抗毒素系统：从调控到生物学功能
Selene F H Shore,Florian H Leinberger,Elizabeth M Fozo et al.
Selene F H Shore et al.
Toxin-antitoxin systems are ubiquitous in the prokaryotic world and widely distributed among chromosomes and mobile genetic elements. Several different toxin-antitoxin system types exist, but what they all have in common is that toxin activ...
Sudhir Doranga,Karen A Krogfelt,Paul S Cohen et al.
Sudhir Doranga et al.
In this chapter, we update our 2004 review of "The Life of Commensal Escherichia coli in the Mammalian Intestine" (https://doi.org/10.1128/ecosalplus.8.3.1.2), with a change of title that reflects the current focus on "Nutrition of E. coli ...
Jing Han,Nesreen Aljahdali,Shaohua Zhao et al.
Jing Han et al.
Salmonella enterica is the leading cause of bacterial foodborne illness in the USA, with an estimated 95% of salmonellosis cases due to the consumption of contaminated food products. Salmonella can cause several different disease syndromes,...