Andreas Kuhn,Hans-Georg Koch,Ross E Dalbey
Andreas Kuhn
The insertion and assembly of proteins into the inner membrane of bacteria are crucial for many cellular processes, including cellular respiration, signal transduction, and ion and pH homeostasis. This process requires efficient membrane ta...
Type I Protein Secretion-Deceptively Simple yet with a Wide Range of Mechanistic Variability across the Family [0.03%]
第一类蛋白分泌系统-简单却机制多样
I Barry Holland,Sandra Peherstorfer,Kerstin Kanonenberg et al.
I Barry Holland et al.
A very large type I polypeptide begins to reel out from a ribosome; minutes later, the still unidentifiable polypeptide, largely lacking secondary structure, is now in some cases a thousand or more residues longer. Synthesis of the final hu...
Live Attenuated Human Salmonella Vaccine Candidates: Tracking the Pathogen in Natural Infection and Stimulation of Host Immunity [0.03%]
减毒活的人用沙门氏菌疫苗候选者：追踪病原体在自然感染中的情况以及刺激宿主免疫反应
James E Galen,Amanda D Buskirk,Sharon M Tennant et al.
James E Galen et al.
Salmonellosis, caused by members of the genus Salmonella, is responsible for considerable global morbidity and mortality in both animals and humans. In this review, we will discuss the pathogenesis of Salmonella enterica serovar Typhi and S...
J Daniel Dubreuil,Richard E Isaacson,Dieter M Schifferli
J Daniel Dubreuil
Enterotoxigenic Escherichia coli (ETEC) is the most common cause of E. coli diarrhea in farm animals. ETEC are characterized by the ability to produce two types of virulence factors: adhesins that promote binding to specific enterocyte rece...
Peter J Christie
Peter J Christie
Escherichia coli and other Gram-negative and -positive bacteria employ type IV secretion systems (T4SSs) to translocate DNA and protein substrates, generally by contact-dependent mechanisms, to other cells. The T4SSs functionally encompass ...
Constanze Pinske,R Gary Sawers
Constanze Pinske
Numerous recent developments in the biochemistry, molecular biology, and physiology of formate and H2 metabolism and of the [NiFe]-hydrogenase (Hyd) cofactor biosynthetic machinery are highlighted. Formate export and import by the aquaporin...
The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin [0.03%]
肠杆菌类 genotoxins：细胞毒肿胀毒素和colibactin
Frederic Taieb,Claude Petit,Jean-Philippe Nougayrède et al.
Frederic Taieb et al.
While the DNA damage induced by ionizing radiation and by many chemical compounds and drugs is well characterized, the genotoxic insults inflicted by bacteria are only scarcely documented. However, accumulating evidence indicates that we ar...
Gottfried Unden,Alexander Strecker,Alexandra Kleefeld et al.
Gottfried Unden et al.
C4-dicarboxylates and the C4-dicarboxylic amino acid l-aspartate support aerobic and anaerobic growth of Escherichia coli and related bacteria. In aerobic growth, succinate, fumarate, D- and L-malate, L-aspartate, and L-tartrate are metabol...
Kyeong Rok Choi,Jae Ho Shin,Jae Sung Cho et al.
Kyeong Rok Choi et al.
Systems metabolic engineering, which recently emerged as metabolic engineering integrated with systems biology, synthetic biology, and evolutionary engineering, allows engineering of microorganisms on a systemic level for the production of ...
Kenan C Murphy
Kenan C Murphy
The bacteriophage λ Red homologous recombination system has been studied over the past 50 years as a model system to define the mechanistic details of how organisms exchange DNA segments that share extended regions of homology. The λ Red ...