Shunyu Yao,Zixi Zhao,Weijun Wang et al.
Shunyu Yao et al.
The prevalence of inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), increases gradually worldwide in the past decades. IBD is generally associated with the change of the immune system and gut...
Association of the PINX1 Variant rs6984094, Which Lengthens Telomeres, with Systemic Lupus Erythematosus Susceptibility in Chinese Populations [0.03%]
中国人群PINX1基因rs6984094位点与系统性红斑狼疮易感性的关联及其可能机制研究
Yuan-Yuan Qi,Xin-Ran Liu,Ying-Xin He et al.
Yuan-Yuan Qi et al.
A recent genome-wide association study (GWAS) of Asian ancestry reported that single nucleotide polymorphism (SNP) in TERT (telomerase reverse transcriptase) was associated with systemic lupus erythematosus (SLE). TERT has a critical role i...
Observational Study
Journal of immunology research. 2021 Jul 13:2021:7079359. DOI:10.1155/2021/7079359 2021
Selective Cytotoxicity of Single and Dual Anti-CD19 and Anti-CD138 Chimeric Antigen Receptor-Natural Killer Cells against Hematologic Malignancies [0.03%]
单个及双二价抗CD19和抗CD138嵌合抗原受体自然杀伤细胞选择性地对血液系统恶性肿瘤产生细胞毒性作用
Sudjit Luanpitpong,Jirarat Poohadsuan,Phatchanat Klaihmon et al.
Sudjit Luanpitpong et al.
Natural killer (NK) cells are part of the first line of defense that rapidly respond to malignant transformed cells. Chimeric antigen receptor- (CAR-) engineered NK cells, although are still at the preliminary stage, have been shown to be a...
The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells [0.03%]
雷公藤红素联合他莫昔芬对MCF-7细胞促凋亡及自噬的协同效应研究
Lijun Wang,Luqun Tang,Chengyun Yao et al.
Lijun Wang et al.
Breast cancer is one of the most common cancers among females and is associated with high mortality and morbidity rates. Several studies have demonstrated that combination treatments with natural products and tamoxifen can improve the sensi...
A Hypoxia Gene-Based Signature to Predict the Survival and Affect the Tumor Immune Microenvironment of Osteosarcoma in Children [0.03%]
基于儿童骨肉瘤低氧诱导基因的预后标志物及其对肿瘤免疫微环境的影响研究
Feng Jiang,Xiao-Lin Miao,Xiao-Tian Zhang et al.
Feng Jiang et al.
Osteosarcoma is a quickly developing, malignant cancer of the bone, which is associated with a bad prognosis. In osteosarcoma, hypoxia promotes the malignant phenotype, which results in a cascade of immunosuppressive processes, poor prognos...
Yanyan Zhu,Yumeng Huang,Qian Ji et al.
Yanyan Zhu et al.
The extracellular matrix (ECM) is a highly dynamic and complex network structure, which exists in almost all tissues and is the microenvironment that cells rely on for survival. ECM interacts with cells to regulate diverse functions, includ...
Neuroprotective Effect of Taurine against Cell Death, Glial Changes, and Neuronal Loss in the Cerebellum of Rats Exposed to Chronic-Recurrent Neuroinflammation Induced by LPS [0.03%]
牛磺酸对慢性反复性内毒素诱导的大鼠小脑神经元保护作用的研究
Samara P Silva,Adriana M Zago,Fabiano B Carvalho et al.
Samara P Silva et al.
The present study investigated the neuroprotective effect of taurine against the deleterious effects of chronic-recurrent neuroinflammation induced by LPS in the cerebellum of rats. Adult male Wistar rats were treated with taurine for 28 da...
The Ablation of Envelope Protein Glycosylation Enhances the Neurovirulence of ZIKV and Cell Apoptosis in Newborn Mice [0.03%]
寨卡病毒包膜蛋白糖基化消除能够增强其对新生小鼠的神经毒力并诱导细胞凋亡
Yanqing Guo,Linlin Bao,Yanfeng Xu et al.
Yanqing Guo et al.
Zika virus (ZIKV) has attracted the wide global attention due to its causal link to microcephaly. In this study, two amino acid (aa) mutation (E143K and R3394K) were identified at the fourth generation (named ZKC2P4) during the serial passa...
Acacetin Protects Myocardial Cells against Hypoxia-Reoxygenation Injury through Activation of Autophagy [0.03%]
芦丁通过激活自噬来保护心肌细胞免受缺氧/复氧损伤
Chong Liu,Minmin Zhang,Shenyi Ye et al.
Chong Liu et al.
Ischemic heart disease is a leading cause of mortality and morbidity worldwide. We previously demonstrated that acacetin protects against myocardial ischemia reperfusion injury in rats, although the underlying mechanism remains to be elucid...
KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D [0.03%]
KDM1A通过去甲基化MEF2D调节PD-L1从而促进肝细胞癌免疫抑制作用
Yonglan Wang,Kun Cao
Yonglan Wang
Background: Immune checkpoint inhibitor therapy targeting antiprogrammed cell death-1 (anti-PD-1) or its ligand (anti-PD-L1) is effective in the treatment of some hepatocellular carcinomas (HCC). Hence, further identifica...