Bone Marrow Neutrophils of Multiple Myeloma Patients Exhibit Myeloid-Derived Suppressor Cell Activity [0.03%]
多发性骨髓瘤患者的骨髓中性粒细胞表现出髓系源抑制细胞活性
Julia Petersson,Sandra Askman,Åsa Pettersson et al.
Julia Petersson et al.
Activated normal density granulocytes (NDGs) can suppress T-cell responses in a similar way as myeloid-derived suppressor cells (MDSCs). In this study, we tested the hypothesis that NDGs from blood and bone marrow of multiple myeloma (MM) p...
lncRNA DCST1-AS1 Facilitates Oral Squamous Cell Carcinoma by Promoting M2 Macrophage Polarization through Activating NF- κ B Signaling [0.03%]
长链非编码RNA DCST1-AS1通过激活NF-κB信号促进M2型巨噬细胞极化从而促进口腔鳞状细胞癌的发展
Yilong Ai,Shiwei Liu,Hailing Luo et al.
Yilong Ai et al.
lncRNAs are related to the progression of various diseases, including oral squamous cell carcinoma (OSCC), which is a common squamous cell carcinoma of the head and neck. Tumor-associated macrophages and tumor cells are significant componen...
Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients [0.03%]
维生素D调节重度哮喘患者血液中糖皮质激素受体的表达
Bassam Mahboub,Saba Al Heialy,Mahmood Yaseen Hachim et al.
Bassam Mahboub et al.
Purpose: Vitamin D (VitD) deficiency is a significant public health concern in many areas around the globe and has been associated with many immune-mediated diseases, including asthma. Severe asthma has been linked to a d...
HuR Plays a Positive Role to Strengthen the Signaling Pathways of CD4+ T Cell Activation and Th17 Cell Differentiation [0.03%]
HuR在CD4+T细胞活化和Th17细胞分化信号通路中发挥正向调控作用
Shiguang Yu,Morgan Tripod,Ulus Atasoy et al.
Shiguang Yu et al.
After antigen and/or different cytokine stimulation, CD4+ T cells activated and differentiated into distinct T helper (Th) cells via differential T cell signaling pathways. Transcriptional regulation of the activation and differentiation of...
Inflamm-Aging-Related Cytokines of IL-17 and IFN- γ Accelerate Osteoclastogenesis and Periodontal Destruction [0.03%]
炎症老化相关细胞因子白介素-17和干扰素-γ促进破骨细胞生成及牙周破坏
Jingyi Tan,Anna Dai,Lai Pan et al.
Jingyi Tan et al.
Periodontal disease (PD), as an age-related disease, prevalent in middle-aged and elderly population, is characterized as inflammatory periodontal tissue loss, including gingival inflammation and alveolar bone resorption. However, the defin...
Hai-Peng Wei,Song Zhan,Qing-An Zhu et al.
Hai-Peng Wei et al.
Distinct expression of the miRNAs has rarely been explored in basal cell carcinoma (BCC) of skin, and the regulatory role of miRNAs in BCC development remains quite opaque. Here, we collected control tissues from adjacent noncancerous skin ...
Inhibition of NF- κ B/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus [0.03%]
NF- κ B/IL-33/ST2信号轴的抑制改善呼吸道合胞病毒急性支气管炎症状
Liwen Zhang,Yu Wan,Liang Ma et al.
Liwen Zhang et al.
Background/aim: Bronchiolitis is a common acute lower respiratory tract infectious disease in infants. Respiratory syncytial virus (RSV) infection is one of the main causes. Bronchiolitis can lead to a significant increas...
Complement Inhibitors in Age-Related Macular Degeneration: A Potential Therapeutic Option [0.03%]
补体抑制剂在年龄相关性黄斑变性中具有潜在治疗价值
Shuqi Qin,Ning Dong,Ming Yang et al.
Shuqi Qin et al.
Age-related macular degeneration (AMD) is a multifactorial disease, which can culminate in irreversible vision loss and blindness in elderly. Nowadays, there is a big gap between dry AMD and wet AMD on treatment. Accounting for nearly 90% o...
A Novel Immune-Related lncRNA-Based Model for Survival Prediction in Clear Cell Renal Cell Carcinoma [0.03%]
一种基于新型免疫相关长链非编码RNA的透明细胞肾细胞癌预后模型
Zedan Zhang,Yanlin Tang,Yanjun Liu et al.
Zedan Zhang et al.
Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer whose incidence and mortality rate are increasing. Identifying immune-related lncRNAs and constructing a model would probably...
lncRNA OIP5-AS1 Suppresses Cell Proliferation and Invasion of Endometrial Cancer by Regulating PTEN/AKT via Sponging miR-200c-3p [0.03%]
长链非编码RNA OIP5-AS1通过海绵吸附miR-200c-3p调控PTEN/AKT信号通路抑制子宫内膜癌细胞增殖侵袭功能
Yun Liu,Xiaohui Cai,Yixuan Cai et al.
Yun Liu et al.
Background: Endometrial carcinoma (EC) is one of the major gynecologic malignancy cancers affecting females with dismal prognosis and high mortality around the world. Numerous studies have proven that an aberrant level of...