Immunomodulatory Effects of Canine Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles on Stimulated CD4+ T Cells Isolated from Peripheral Blood Mononuclear Cells [0.03%]
来源于外周血单个核细胞的刺激性CD4⁺T淋巴细胞与犬脂肪来源间充质干细胞分泌体的免疫调节作用研究
Takahiro Teshima,Yunosuke Yuchi,Ryohei Suzuki et al.
Takahiro Teshima et al.
Adipose tissue-derived mesenchymal stem cells (ADSCs) have anti-inflammatory and immunomodulatory characteristics. Many studies have suggested that the immunomodulation of ADSCs is largely mediated by secreted paracrine factors. Various fac...
iNOS Promotes the Development of Osteosarcoma via Wnt/ β-Catenin Pathway [0.03%]
iNOS通过Wnt/β-catenin信号通路促进骨肉瘤的发生发展
Wei Chu,Lirong Cao,Gui Daokun et al.
Wei Chu et al.
Inducible nitric oxide synthase (iNOS), accompanied with protumor and antitumor activity, has been studied in multiple cancers. However, the role of iNOS expression in osteosarcoma (OS) is far from being fully understood. In present work, i...
Observational Study
Journal of immunology research. 2021 Aug 16:2021:4549221. DOI:10.1155/2021/4549221 2021
Screening Prognosis-Related lncRNAs Based on WGCNA to Establish a New Risk Score for Predicting Prognosis in Patients with Hepatocellular Carcinoma [0.03%]
基于WGCNA筛查预后相关的长链非编码RNA以建立新的列线图预测肝细胞癌患者的预后风险评分模型
Xueliang Zhou,Mengmeng Dou,Zaoqu Liu et al.
Xueliang Zhou et al.
Background: Hepatocellular carcinoma (HCC) remains an important cause of cancer death. The molecular mechanism of hepatocarcinogenesis and prognostic factors of HCC have not been completely uncovered. ...
Effects of Fatty Acid Oxidation and Its Regulation on Dendritic Cell-Mediated Immune Responses in Allergies: An Immunometabolism Perspective [0.03%]
从免疫代谢角度探究脂肪酸氧化及其调控对过敏反应中树突状细胞介导的免疫应答的影响
Shanfeng Sun,Yanjun Gu,Junjuan Wang et al.
Shanfeng Sun et al.
Type 1 allergies, involve a complex interaction between dendritic cells and other immune cells, are pathological type 2 inflammatory immune responses against harmless allergens. Activated dendritic cells undergo extensive phenotypic and fun...
Therapeutic Effect of Matrine on Collagen-Induced Arthritis Rats and Its Regulatory Effect on RANKL and OPG Expression [0.03%]
氧化苦参碱治疗胶原诱导型 arthritis 小鼠的研究及其对 Rankl/Opq 表达的调节作用研究
Xin Li,Lijie Zhang,Yongsong Xu et al.
Xin Li et al.
Objective: To investigate the effect of matrine on rats with collagen-induced arthritis (CIA) and its regulatory effect on receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) expression. ...
Propofol Ameliorates Microglia Activation by Targeting MicroRNA-221/222-IRF2 Axis [0.03%]
异丙酚通过靶向微小RNA-221/222-IRF2轴抑制小胶质细胞激活
Xi Xiao,Yuanyuan Hou,Wei Yu et al.
Xi Xiao et al.
Background: Propofol is a widely used intravenous anesthetic drug with potential neuroprotective effect in diverse diseases of neuronal injuries such as traumatic brain injury and ischemic stroke. However, the underlying ...
Citrullinated Antigens with Multiple Citrulline Similar Motif in the Diagnosis of Rheumatoid Arthritis: A Preliminary Single-Center Study [0.03%]
瓜氨酸多态性抗原在类风湿关节炎诊断中的应用价值初步研究
Zhu Chen,Weiting Fang,Yi Qin et al.
Zhu Chen et al.
The presence of anti-citrullinated protein antibodies (ACPAs) in the serum is one of the immunological features of rheumatoid arthritis (RA). Anti-cyclic citrullinated peptide (CCP) assay has been widely used in clinic for the diagnosis of ...
Identification of Key Functional Modules and Immunomodulatory Regulators of Hepatocellular Carcinoma [0.03%]
肝细胞癌的功能模块和免疫调节因子的鉴定
Ding Luo,Xiang Zhang,Xiao-Kai Li et al.
Ding Luo et al.
Despite the advances in the treatment of hepatocellular carcinoma (HCC), the prognosis of HCC patients remains unsatisfactory due to postsurgical recurrence and treatment resistance. Therefore, it is important to reveal the mechanisms under...
lncRNA PANTR1 Upregulates BCL2A1 Expression to Promote Tumorigenesis and Warburg Effect of Hepatocellular Carcinoma through Restraining miR-587 [0.03%]
长链非编码RNA PANTR1通过限制miR-587促进肝细胞癌肿瘤发生及瓦博格效应的分子机制研究
Xirui Ma,Ziming Mao,Jing Zhu et al.
Xirui Ma et al.
Hepatocellular carcinoma (HCC) is one of the most common subtypes of malignant liver tumors, characterized by high morbidity and mortality. Due to its poor diagnosis strategy and inefficient clinical intervention, HCC has brought terrible l...
Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases [0.03%]
子宫敏化相关基因-1在肾脏疾病进展中的作用
Xiaohu Li,Wenlong Yue,Guiwen Feng et al.
Xiaohu Li et al.
Uterine sensitization-associated gene-1 (USAG-1), originally identified as a secretory protein preferentially expressed in the sensitized rat endometrium, has been determined to modulate bone morphogenetic protein (BMP) and Wnt expression t...