Peripheral Blood Neutrophils and Monocytes Predict Disease Progression in Stage III Melanoma Patients Treated With Anti Programmed Cell Death Protein-1 (PD-1) Inhibitors [0.03%]
抗程序性细胞死亡蛋白-1(PD-1)抑制剂治疗III期黑色素瘤患者外周血中性粒细胞和单核细胞可预测疾病进展风险
Annagioia Ventrici,Luca Modestino,Leonardo Cristinziano et al.
Annagioia Ventrici et al.
Melanoma is a global health issue, with an increasing incidence in recent years. Immune checkpoint inhibitors (ICIs, e.g., antiprogrammed cell death protein 1 [PD-1]) and targeted therapies (e.g., BRAF/MEK inhibitors) have revolutionized tr...
Estrogen Induced Regulation of Mucosal-Associated Invariant T Cells in Asthma [0.03%]
雌激素通过调控粘膜相关不变自然杀伤T细胞诱导哮喘表型的性别差异
Shubhanshi Trivedi,Samuel E Aamodt,Thomas P Huecksteadt et al.
Shubhanshi Trivedi et al.
Asthma affects over 300 million people worldwide, with increasing rates annually. Males have higher asthma prevalence in adolescence, while females exhibit higher rates in adulthood. Reduced mucosal-associated invariant T (MAIT) cells are f...
Integration of SFTSV Viral Load, Age, and Double-Negative B-Cells as Prognostic Biomarkers for Severe Fever With Thrombocytopenia Syndrome Outcomes [0.03%]
整合SFTSV病毒载量、年龄和双阴性B细胞作为严重发热伴血小板减少综合征预后生物标志物
Wei Wei,Qian Tai,Heng Liu et al.
Wei Wei et al.
Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral illness with high mortality, yet early risk stratification remains challenging. Recent evidence suggests that B-cell dysregulation contr...
MicroRNA-382 Is Involved in Acute Kidney Injury via Regulating STAT1 Signaling [0.03%]
microRNA-382通过调节STAT1信号参与急性肾损伤
Xiaoyan Wang,Guo Cheng,Ting Ren et al.
Xiaoyan Wang et al.
Acute kidney injury (AKI), characterized by inflammation and oxidative stress, is a life-threatening clinical presentation. We previously demonstrated the role of miR-382 in the progression of chronic kidney disease (CKD). However, the role...
Immunophenotypic Stratification of Primary Sjögren's Syndrome Reveals Distinct Lymphocyte Profiles and Clinical Manifestations [0.03%]
免疫表型分类的一线斯乔格伦综合征展现出不同的淋巴细胞谱系和临床表现
Yimeng Jia,Sicheng Huang,Ye Guo et al.
Yimeng Jia et al.
Objective: Primary Sjögren's syndrome (pSS) is a heterogeneous autoimmune disorder with diverse clinical manifestations and limited effective therapies. This study aimed to stratify pSS patients into distinct immunopheno...
RETRACTION: Glycyrrhizin Attenuates Toll Like Receptor-2, -4 and Experimental Vasospasm in a Rat Model [0.03%]
撤稿：甘草甜素通过抑制 toll 样受体-2、-4 及实验性血管痉挛减轻作用的研究（大鼠模型）
Journal Of Immunology Research
Journal Of Immunology Research
Piplartine as an Innovative Natural Product With Dual Antiparasitic and Immunomodulatory Actions [0.03%]
具有抗寄生虫和免疫调节双重作用的新型天然产物piplartine的研究
Lucas Fukui-Silva,Felipe C R de Souza,Camila S Amorim et al.
Lucas Fukui-Silva et al.
Neglected tropical diseases (NTDs) remain a major global health burden, disproportionately affecting low- and middle-income regions and demanding innovative therapeutic strategies. This review summarizes current evidence on piplartine (pipe...
Neutrophil Extracellular Trap-Related Gene Signatures and Molecular Clusters in Severe Influenza: Identification Through Integrative Transcriptome Analysis [0.03%]
通过整合转录组分析识别严重流感中的中性粒细胞胞外诱捕相关基因特征和分子亚群
Libo Fei,Liang Chen
Libo Fei
Background: Neutrophil extracellular traps (NETs) are recently discovered structures in which neutrophils trap pathogens in web-like structures composed of chromatin and proteolytic material. NETs have been linked to tiss...
Proportion, Function, and Generation of Dual Receptor Lymphocytes [0.03%]
双重受体淋巴细胞的 proportions、功能和生成
Qi Peng,Lanwei Zhu,XiaoPing Lu et al.
Qi Peng et al.
The specific immune response mechanisms of B cells and T cells are centered on the classic clonal selection theory, which posits that "a single lymphocyte expresses only one type of antigen receptor." This mechanism is primarily achieved th...
SARS-CoV-2-Induced Macrophage Polarization Reverses HIV-1 Latency in J-Lat Cells Through TNFα Signaling [0.03%]
SARS-CoV-2诱导的巨噬细胞极化通过TNFα信号在J-Lat细胞中逆转HIV-1潜伏感染
Patricio Jarmoluk,Franco Agustín Sviercz,Cintia Cevallos et al.
Patricio Jarmoluk et al.
Introduction: Coronavirus disease 2019 (COVID-19) may have both short- and long-term impacts on the progression of human immunodeficiency virus (HIV)-1 after acute SARS-CoV-2 infection in people living with HIV (PLWH), ev...