Pilot Study to Improve In Vitro Identification of Culprit Drugs in SJS/TEN Using Granzyme B and Granulysin Secretion Assays [0.03%]
用于改善SJS/TEN罪魁祸首药物体外识别的颗粒酶B和粒细胞素分泌试验的试点研究
Yuttana Srinoulprasert,Somkiat Ud-Naen,Tunsuda Tansit et al.
Yuttana Srinoulprasert et al.
Introduction: Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions (SCARs) with high morbidity and mortality. Accurate identification of the culprit drug is critical ...
Exercise Attenuates Neuroinflammation in Chronic Restraint Stress Induced Depression Model by Downregulating GDF15 Expression [0.03%]
运动通过下调GDF15的表达来削弱慢性束缚应激诱导的抑郁模型中的神经炎症反应
Junrui Chen,Chunxiao Du,Jiawen Lu et al.
Junrui Chen et al.
Exercise has been shown to alleviate depressive symptoms and enhance bodily functions. However, the precise mechanisms underlying its antidepressant effects remain incompletely understood. In this study, we observed that treadmill exercise ...
Optimization of Erythrocyte Lysis Protocols for Robust and Reproducible T Cell Analysis in Murine Peripheral Blood, Spleen, Lung, and Bone Marrow [0.03%]
优化红细胞裂解方案以实现小鼠外周血、脾脏、肺和骨髓T细胞分析的稳健性和可重复性
Wei-Qian Bao,Meng-Lin Jiang,Nan-Jie Zhou et al.
Wei-Qian Bao et al.
Flow cytometry analysis of T lymphocytes in murine peripheral blood, spleen, lung, and bone marrow is critical for immune studies. However, inconsistent erythrocyte lysis remains a major challenge-incomplete lysis obscures lymphocyte detect...
A Bead-Based Screening Platform for Identifying Monoclonal Antibodies That Disrupt PD-1/PD-L1 Interactions [0.03%]
一种基于磁珠的筛选平台用于识别可破坏PD-1/PD-L1相互作用的单克隆抗体
Veridiane M Pscheidt,Rodrigo B Gassen,José E Sacconi Nunes et al.
Veridiane M Pscheidt et al.
Monoclonal antibodies (mAbs) targeting immune checkpoint pathways such as programmed cell death protein 1 (PD-1)/PD-L1 are central to modern immunotherapy, yet scalable methods to assess their functional blockade remain limited. We present ...
Attenuated Infectious Bronchitis Virus (IBV) Vaccination Induces Protective Humoral and Cellular Immunity Against SARS-CoV-2 in Mammals [0.03%]
attenuated传染性支气管炎病毒(IBV)疫苗诱导哺乳动物预防SARS-CoV-2的体液免疫和细胞免疫
Ney de Carvalho Almeida,Mauricio Fraga van Tilburg,Bruno Bezerra da Silva et al.
Ney de Carvalho Almeida et al.
Occupational exposure to infectious bronchitis virus (IBV) has been associated with cross-reactivity to other coronaviruses such as SARS-CoV-2. In this study, we investigated the immune response of IBV using reconstituted samples of the com...
From Demyelination to Intervention: Natural Compounds as Emerging Therapeutic Targets in Multiple Sclerosis Neuroinflammation [0.03%]
从脱髓鞘到干预：天然化合物作为多发性硬化症神经炎症新兴治疗靶点的发展历程
Zhiyong Long,Qianyue Yang,Yonghe Wu et al.
Zhiyong Long et al.
Multiple sclerosis (MS) is a chronic immune-mediated inflammatory demyelinating disease of the central nervous system (CNS), characterized by multifocal lesions, axonal damage, and progressive neurological dysfunction, imposing a heavy burd...
The Role of MicroRNAs in Treg-Derived Extracellular Vesicles: A Narrative Review Focusing on Immune-Related Diseases [0.03%]
微环境中Tregs细胞来源的外泌体的作用：集中论述与免疫相关疾病的叙事性综述
Yudong Gao,Juncheng Zhou,Yuwen Mao et al.
Yudong Gao et al.
Regulatory T cells (Tregs) are a unique class of immunosuppressive cells that play a key role in managing immune-related diseases. Growing evidence indicates that the immunosuppressive effects of Tregs also rely on cell-to-cell interactions...
Analysis of the Mediating Effect of Vitamin D via the TGF-β1/Treg Pathway in the Pathogenesis of Childhood Primary Immune Thrombocytopenia [0.03%]
维生素D通过TGF-β1/Treg途径在儿童原发性免疫性血小板减少症发病机制中的中介作用分析
Peiling Li,Mengru Chen,Zhihang Wang et al.
Peiling Li et al.
Objective: To investigate the role of vitamin D (VitD), transforming growth factor-β1 (TGF-β1), and regulatory T cells (Treg) in the pathogenesis of primary immune thrombocytopenia (ITP) in children. ...
Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease [0.03%]
Sjögren病中IFN-γ和IL-21驱动外周唾液腺年龄相关B细胞的扩增
Mari Nishida,Kunihiro Otsuka,Ruka Nagao et al.
Mari Nishida et al.
Sjögren disease (SjD) is an autoimmune disorder that predominantly affects the exocrine glands, and advancing age is recognized as an important risk factor for its development. However, the mechanisms linking age and disease progression re...
Peripheral Blood Neutrophils and Monocytes Predict Disease Progression in Stage III Melanoma Patients Treated With Anti Programmed Cell Death Protein-1 (PD-1) Inhibitors [0.03%]
抗程序性细胞死亡蛋白-1(PD-1)抑制剂治疗III期黑色素瘤患者外周血中性粒细胞和单核细胞可预测疾病进展风险
Annagioia Ventrici,Luca Modestino,Leonardo Cristinziano et al.
Annagioia Ventrici et al.
Melanoma is a global health issue, with an increasing incidence in recent years. Immune checkpoint inhibitors (ICIs, e.g., antiprogrammed cell death protein 1 [PD-1]) and targeted therapies (e.g., BRAF/MEK inhibitors) have revolutionized tr...