Spermidine Remodels the Mitochondrial Metabolism of Tumor-Infiltrating Lymphocytes [0.03%]
精胺重塑肿瘤浸润淋巴细胞的线粒体代谢
Yizhe Sun,Hao Fu,Xinyu Li et al.
Yizhe Sun et al.
Adoptive cell therapy (ACT) utilizing tumor-infiltrating lymphocytes (TILs) has significant potential in treating various cancers; however, its effectiveness is often compromised by the tendency of TILs to become exhausted and dysfunctional...
Cytokine Profile in the Upper Airways of Patients With N-ERD Obtained via a Minimally Invasive Method [0.03%]
通过微创方法获得的N-ERD患者上呼吸道细胞因子谱型
Karolina Frachowicz-Guerreiro,Adrian Gajewski,Rafał Ćwikliński et al.
Karolina Frachowicz-Guerreiro et al.
Introduction: NSAID-exacerbated respiratory disease (N-ERD) is a bronchial asthma phenotype characterized by the coexistence of NSAID hypersensitivity, lower airway symptoms, and severe chronic sinusitis with nasal polyps...
High Fat and Sugar Diet Increases Enteric cDC1 and Oral Antigen-Specific Tregs [0.03%]
高脂高糖饮食增加肠固有层cDC1和口腔抗原特异性Treg细胞
K Fischer,O Horno,B Raposo et al.
K Fischer et al.
Diet-induced obesity is a growing global health concern linked to various immunological alterations. Dendritic cells (DCs) are major regulators of the balance between pro-inflammatory and tolerogenic immune responses. Conventional Type 1 DC...
The Role of Neuroinflammation in the Pathogenesis of Hepatic Encephalopathy [0.03%]
神经炎症在肝性脑病发病机制中的作用
Kathryn Rhodes,Yubo Wang,Sharon DeMorrow et al.
Kathryn Rhodes et al.
Liver disease impacts millions of Americans every year, which is compounded by the comorbidities and consequences that patients are susceptible to developing. Hepatic encephalopathy (HE) is a severe consequence of liver failure resulting in...
Atypical Phenotype of Predominant Autoimmune Cytopenia and Impaired Perforin Expression in XMEN Syndrome [0.03%]
XMEN综合征以自身免疫性细胞减少和穿孔素表达缺乏为特征的不典型表型
Hana Grombirikova,Adam Markocsy,Anna Kocurkova et al.
Hana Grombirikova et al.
X-linked immunodeficiency with magnesium defect, Epstein-Barr virus (EBV) infection, and neoplasia (XMEN) is caused by a pathogenic variant in the magnesium transporter 1 (MAGT1) gene. The defect leads to impaired N-glycosylation which affe...
A Systematic Review of Ocular Complications Following Different Types of Covid-19 Vaccines [0.03%]
不同类型的新冠疫苗后眼部并发症的系统评价
Bahareh Ebrahimi,Hossein Kargar Jahromi,Nazanin Shafiei Jahromi et al.
Bahareh Ebrahimi et al.
Introduction: More than 6 million deaths from the novel coronavirus, the Coronavirus disease 2019 (COVID-19) infection, have prompted the development of several prophylactic vaccines of COVID-19. This systematic review su...
Rational Design and In Silico Evaluation of a Multiepitope Vaccine Targeting the uPAR for Cancer Immunotherapy [0.03%]
基于uPAR的癌免疫治疗多表位疫苗的理性设计与计算机辅助评价
Fahimeh Baghaei,Zahra Hemmat,Amir Taherkhani et al.
Fahimeh Baghaei et al.
Background: The urokinase plasminogen activator receptor (uPAR) plays a crucial role in cancer development and progression, making it an attractive target for immunotherapeutic strategies. This study aimed to develop a mu...
Follicular Helper T Cells: Potential Interventional Targets in Atherosclerosis [0.03%]
滤泡辅助性T细胞在动脉粥样硬化中的潜在作用及干预靶点研究进展
Yuxuan Chen,Wenxin Wang,Xueli Xia et al.
Yuxuan Chen et al.
Atherosclerosis (AS) is a disease characterized by the presence of lesions in the arterial intima throughout the circulatory system. Lipid metabolism disorders form the pathological basis of AS. Immune injury resulting from lipid deposition...
Focus on Interferon Signature in Cutaneous Lupus Erythematosus: Novel Therapies From Better Understanding of the Pathogenesis [0.03%]
干扰素印记在盘状红斑狼疮中的作用：更好的理解病理机制带来新的治疗方法
Min Gao,Nenghan Zhang,Yumin Xia
Min Gao
Cutaneous lupus erythematosus (CLE), a common clinical manifestation of lupus erythematosus (LE), significantly compromises patients' quality of life and social functioning due to its relatively high prevalence. While the exact pathogenesis...
Unmasking Budgerigar Splenic Leukocyte Populations With Single-Cell Transcriptomics and Multiplex RNA In Situ Hybridization [0.03%]
基于单细胞转录组和多重RNA原位杂交解析小凤头鹦鹉脾脏白细胞图谱
Anne De Meyst,Kelly Lemeire,Amanda Gonçalves et al.
Anne De Meyst et al.
The current understanding of the avian immune system primarily stems from research conducted in chickens, given their economic significance as a food source. Extending the research to other avian species like Psittaciformes requires the use...