Immunophenotypic Profiling of Lymphocyte Subsets in Children and Adolescents With Acute Lymphoblastic Leukaemia: Immune Dysregulation Before and After Remission [0.03%]
儿童及青少年急性淋巴细胞白血病各免疫亚群的流式细胞检测：诱导缓解前后的免疫紊乱
Hanaa Nafady-Hego,Arwa Flemban,Saeed Kabrah et al.
Hanaa Nafady-Hego et al.
Background: Acute lymphoblastic leukaemia (ALL) in children is often associated with immune dysfunction, including alterations in regulatory T cells (Treg), impaired T-cell activation, and disrupted natural killer (NK) ce...
PD-L1 Expression in Acute Myeloid Leukemia Cells: Associations With Cell Metabolism [0.03%]
急性髓系白血病细胞中PD-L1的表达与细胞代谢的关系
Tereza Kořánová,Barbora Brodská,Antonín Ptáček et al.
Tereza Kořánová et al.
The programmed death ligand 1 (PD-L1) is a prominent mediator of immune system inhibition in various cancer types. In acute myeloid leukemia (AML), the prognostic meaning of PD-L1 expression is still unclear and likely depends on the mechan...
Distinct Longitudinal Trajectories of SLEDAI-2K Scores Predict Prognosis in Systemic Lupus Erythematosus Based on Group-Based Trajectory Modeling [0.03%]
基于聚类分析的SLEDAI-2K评分纵向轨迹与系统性红斑狼疮预后的关系
Renren Ouyang,Ali Xiong,Xiaochun Shu et al.
Renren Ouyang et al.
Objective: To apply group-based trajectory modeling (GBTM) to longitudinal real world data from patients with systemic lupus erythematosus (SLE) to identify distinct disease activity trajectories and factors associated wi...
Xi Cheng,Hong Pan,Yong Dong et al.
Xi Cheng et al.
Metal ions are key regulators of the neuro-immune-tumor axis. Recent studies provide concrete evidence that neuronal Ca2+ pulses drive tumor-neuron integration and shape immune signaling. Synaptic Zn2+ and ZIP transporters modulate synaptic...
A Novel Magnetically Targeted Intramedullary (MagIC-TI) Xenograft Model for Precise Leukemia Modeling and Drug Resistance Evaluation in the Bone Marrow Niche [0.03%]
一种新颖的磁性靶向骨髓龛白血病建模和药物耐药性评价的骨内移植(MagIC-TI)异种移植模型
Qiusui Mai,Taosong Liu,Luxia Tang et al.
Qiusui Mai et al.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to drug resistance and relapse, which are often driven by the protective bone marrow (BM) niche. Conventional xenograft models fail to adequately recapitulate this niche-speci...
From Defense to Disease: NADPH Oxidase in Cellular Function and Dysregulation [0.03%]
从防御到疾病：NADPH氧化酶在细胞功能和失调中的作用
Ankush Prasad,Renu Kushwaha,Phaniendra Alugoju et al.
Ankush Prasad et al.
Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase is an important family of enzymes that produce reactive oxygen species (ROS) and consists of NOX1-5, DUOX1, and DUOX2. These enzymes exhibit diverse tissue distributions w...
Plastrum Testudinis Extract Ameliorates Intervertebral Disc Degeneration by Suppressing NF-κB Mediated Senescence and Inflammation [0.03%]
龟甲提取物通过抑制NF-κB介导的衰老和炎症来改善椎间盘退变
Jiahui He,Yanchi Gan,Peng Zhang et al.
Jiahui He et al.
Background: Intervertebral disc degeneration (IVDD) is a major cause of chronic low-back pain (LBP). The inflammatory environment and senescence of nucleus pulposus cells (NPCs) within the intervertebral disc (IVD) are cr...
Hepatic Arachidonic Acid Dysregulation Impairs Double-Negative Regulatory T Cell-Mediated Immunoregulation via CD39 Downregulation and Drives MASLD Development [0.03%]
肝花生四烯酸失调通过下调CD39介导的双重否定调节性T细胞免疫调节功能障碍驱动MASLD发生
Hua Jin,Xiyu Wang,Xinjuan Liu et al.
Hua Jin et al.
Immune dysregulation is a key driver of metabolic dysfunction-associated steatotic liver disease (MASLD). Double-negative regulatory T (DNT) cells, which are essential for hepatic immune homeostasis, are functionally impaired in MASLD. CD39...
P2 Receptors as Therapeutic Targets in Allergic Rhinitis: Insights From the Use of Natural Products and Preclinical Studies [0.03%]
过敏性鼻炎中P2受体作为治疗靶点的启示：来源于天然产物和药理学研究的思考
Thalita Calvet Pereira,Leandro Rocha,Robson Xavier Faria
Thalita Calvet Pereira
Allergic rhinitis (AR) is a chronic inflammatory disorder of the upper airways that is mediated by immunoglobulin E (IgE) and triggered by environmental allergens. Current pharmacological therapies, including antihistamines, corticosteroids...
T Follicular Helper Cell Immune Signatures Associated With Disease Severity in Severe Fever With Thrombocytopenia Syndrome [0.03%]
严重发热伴血小板减少综合征病情Severity相关T滤泡辅助细胞免疫特征分析
Danning Xu,Ting Wang,Wei Wei et al.
Danning Xu et al.
Background: Severe fever with thrombocytopenia syndrome (SFTS) is marked by high case fatality and profound antiviral immune dysregulation, yet the clinical implications of changes in circulating T follicular helper (Tfh)...