Cytokine Changes With Effective Drug Therapy for Juvenile Myasthenia Gravis [0.03%]
儿童重症肌无力有效药物治疗引起的细胞因子变化
Yuanyuan Geng,Peng Liu,Min Jin et al.
Yuanyuan Geng et al.
Objective: In order to investigate the therapeutic mechanism of Jianpiyiqi Granule in juvenile myasthenia gravis (JMG) and find the immune-associated cytokines or signaling pathways targeted by this intervention. ...
MX2 and IRF7 are Associated With Disease Activity and Renal Involvement in Systemic Lupus Erythematosus: An Exploratory Study [0.03%]
MX2和IRF7与系统性红斑狼疮的疾病活动及肾脏损害的相关性：一项探索性的研究
FengQi Zhang,YiChen Huang,Hang Liu et al.
FengQi Zhang et al.
Background: Systemic lupus erythematosus (SLE) has multiple phenotypes, one of which is lupus nephritis (LN), a very serious complication with a high mortality rate. Patients with LN may require different treatment regime...
Recent Developments in Macrophages Imbalance and Recurrent Spontaneous Abortion [0.03%]
近期巨噬细胞失衡与复发性流产研究进展
Yi Xiao,Fan-Yu Zeng,Jin-Song Liu et al.
Yi Xiao et al.
Recurrent spontaneous abortion (RSA), defined as two or more consecutive pregnancy losses, remains a significant clinical challenge in reproductive medicine. One of the primary reasons of RSA is abnormal immunological circumstances at the i...
Crohn's Disease Phenotype in a Patient With Severe Congenital Neutropenia Caused by CSF3R Variants: Exploring the Pathogenesis and Effects of Thalidomide Treatment [0.03%]
CSF3R变异引起的严重先天性中性粒细胞减少症患者的克罗恩病表型：探讨发病机制和硫唑嘌呤治疗的影响
Yanqiu Wang,Lin Wang,Chun Pan et al.
Yanqiu Wang et al.
This study describes a case of severe congenital neutropenia (SCN) harboring biallelic CSF3R variants and presenting with a novel inflammatory bowel disease (IBD) phenotype that responded remarkably to thalidomide. We performed functional s...
Mitochondrial Transcription Factor A Deficiency in T Cells Leads to Activation of the Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase/Stimulator of Interferon Genes Pathway and Production of Autoantibodies in Mice [0.03%]
T细胞线粒体转录因子A缺乏通过活化环鸟苷酸-腺苷酸合成酶/干扰素基因刺激物通路导致小鼠产生自身抗体
Shuhei Mashimo,Taku Kuwabara,Kei Ito et al.
Shuhei Mashimo et al.
Mitochondrial transcription factor A (TFAM) is a key regulator of mitochondrial DNA transcription and replication. T cell-specific TFAM-deficient mice are immunocompromised, often succumbing to viral infection, and their T cells are unrespo...
Dynamics of Circulating Follicular Helper and Regulatory T-Cell Memory Induced by mRNA, Inactivated, and Live-Attenuated Vaccines [0.03%]
mRNA、灭活和减毒疫苗诱导的循环滤泡辅助性T细胞和调节性T细胞记忆的动力学研究
A China,A Rahman,L Hani et al.
A China et al.
OX40 signaling promotes the differentiation of memory CD4+ T cells into T follicular helper (Tfh) cells that support germinal center (GC) B-cell responses. Using an extended activation-induced marker (AIM) assay based on OX40 (CD134) and CD...
A State of the Art Review on the Recalcitrant Candidiasis as a Clue of Inborn Errors of Immunity in Newborns [0.03%]
新生儿原发性免疫缺陷导致难治性白色念珠菌感染的研究进展
Mahsa Fattahi,Pegah Tamimi,Aliasghar Ghaderi et al.
Mahsa Fattahi et al.
Background: Defects in the development or function of the immune system are characteristic of inborn errors of immunity (IEI), a diverse group of inherited disorders. IEI can manifest in various ways during the neonatal s...
The Relationship Between CCN3 and Rheumatoid Arthritis and Its Potential Therapeutic Value [0.03%]
CCN3与类风湿关节炎的关系及其潜在治疗价值
Ye Yuan,Hui Yin,Mengya Jiao et al.
Ye Yuan et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, progressive joint destruction, and bone damage. Despite advances in disease-modifying antirheumatic drugs (DMARDs), unmet clinical ...
Novel Biomarker for Antimitochondrial Antibodies in Systemic Sclerosis Patients [0.03%]
系统性硬化症患者抗线粒体抗体的新生物标志物
Elvira Favoino,Silvia De Santis,Vasiliki Liakouli et al.
Elvira Favoino et al.
Objective: We previously identified, using a synthetic peptide, namely peptide 4.33 (p4.33), a subgroup of anti-CENP-A antibodies (Abs) recognizing an epitope shared between the CENP-A region spanning amino acids 1-17 (Ap...
Anti-MAG Polyneuropathy: Characterization of the Monoclonal Gammopathy and Clonal B-Cell Population [0.03%]
抗MAG多发性神经病：单克隆免疫球蛋白及克隆B细胞的特征分析
Geir Erland Tjønnfjord,Liv Toril N Osnes,Signe Spetalen et al.
Geir Erland Tjønnfjord et al.
Polyneuropathy due to antibodies to myelin-associated glycoprotein (MAG) is a rare disease with an estimated prevalence of 1 per 100,000. Symptoms start in the sixth or seventh decade of life, presenting sensory polyneuropathy with sensory ...