A Hidden Checkpoint: Bidirectional pH Remodeling of the Immunological Synapse in Cancer, Methods, and Therapeutic Opportunities [0.03%]
隐秘的关卡：癌症免疫学 synapse 的双向 pH 重塑及诊疗策略机遇与方法学挑战
Aurélie Guillemette,Eva Gez,Sofia Titah et al.
Aurélie Guillemette et al.
The immunological synapse (IS) is a nanoscale platform that coordinates T cell activation, cytoskeletal polarization, Ca2+ signaling, and the directed secretion of lytic granules. In cancers, an acidic tumor microenvironment (TME; extracell...
Comparative Analysis of Tumor-Immune Microenvironment Diversity Among Biopsy, Resection, and Metastatic Colorectal Cancer Specimens [0.03%]
活检、手术切除和转移的结直肠癌样本之间的肿瘤免疫微环境多样性比较分析
Qi Liu,Wei Liu,Chunmei Zhang et al.
Qi Liu et al.
Background: Colorectal cancer (CRC) tumor immune microenvironment (TIME) components such as programmed death-ligand 1 (PD-L1) and CD4+T/CD8+T cells play an important role in immunotherapy, which is closely related to the ...
Comparative Study
Journal of immunology research. 2026;2026(1):e9281559. DOI:10.1155/jimr/9281559 2026
MicroRNAs in Acute COVID-19 and Long COVID: Dysregulation, Pathogenic Roles, and Clinical Implications [0.03%]
microRNA在急性COVID-19和长新冠中的功能与调控作用：失调、致病机制及临床意义
Larissa I Silva,Carlos M Gonzalez-Zambrano,Vanessa C M P Ferreira et al.
Larissa I Silva et al.
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression with central roles in immune responses, inflammation, and viral pathogenesis. Increasing evidence indicates that severe acute respiratory syndrome coronavirus (SA...
Endotoxin Tolerance Impinges on T Cell Activation and Chemoattraction in Autoimmune Diabetes [0.03%]
内毒素耐受影响自身免疫糖尿病中的T细胞活化和趋化性
Satu M Silojärvi,Linda A A Leino,Sakari A Pöysti et al.
Satu M Silojärvi et al.
Gut microbiota may affect the development of autoimmune (type 1) diabetes by differential potency of intestinal species to induce endotoxin tolerance (ET). However, where ET impinges on immune mechanisms underlying autoimmune diabetes is ye...
High-Throughput Heterospheroid-Based Screening Identifies Drugs That Reprogram Tumor-Associated Macrophages [0.03%]
高效液滴宏量筛选技术鉴定出能够重编程肿瘤相关巨噬细胞的药物
Hiroyuki Tsuchiya,Takehiko Hanaki,Mayu Obora et al.
Hiroyuki Tsuchiya et al.
The tumor microenvironment (TME) provides a niche for immune evasion and immunotherapy resistance, in part, by recruiting pro-tumor M2-like macrophages. In the present study, using heterospheroids consisting of cancer cells and macrophages,...
Increased IGF-1 and DNA Synthesis in Patients With Activation-Induced Cytidine Deaminase Deficiency [0.03%]
活化诱导的胞苷脱氨酶缺陷患者的IGF-1和DNA合成增加
Gursev Dhaunsi,Waleed Al-Herz
Gursev Dhaunsi
Objective: To characterize patients with activation-induced cytidine deaminase (AICDA) deficiency, a rare autosomal recessive inborn error of immunity (IEI), and examine the role of insulin-like growth factor-1 (IGF-1) an...
cTfh Cell Activation and Changes in BTLA and LAG-3 Expression Differentially Associate With Poor Pregnancy Outcome in Plasmodium falciparum Placental Malaria [0.03%]
恶性疟原虫胎盘疟疾中cTfh细胞活化及BTLA和LAG-3表达变化与不良妊娠结局的差异相关性研究
Bernard Marie Zambo Bitye,Chris Marco Mbianda Nana,Bodin Darcisse Kwanou Tchakounte et al.
Bernard Marie Zambo Bitye et al.
Continuous exposure to antigens drives the activation of circulating T follicular helper (cTfh) cells, promoting high-affinity antibody production. However, sustained stimulation may impair their function through the upregulation of immunor...
C3d Complement Activation and Antibody Immunity in Convalescent COVID-19: Insights From Adults and Children [0.03%]
COVID-19康复期的补体C3d活化和抗体免疫：来自成人和儿童的启示
Ratna Wijaya,Jordan Stoddart,Anurag Adhikari et al.
Ratna Wijaya et al.
Following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the complement pathway becomes activated, generating the stable split product C3d. Although C3d can modulate B cell responses through complement receptor 2 (C...
Regulatory Effects of CD14+CD16++Slan+ Monocytes on Classical Monocytes and T Lymphocytes in Response to Inflammatory and Phagocytic Stimuli [0.03%]
CD14+CD16++Slan+单核细胞调节经典单核细胞和T淋巴细胞对炎症和吞噬刺激的反应
Cristian A Anacona,Karen Álvarez,Gloria Vásquez et al.
Cristian A Anacona et al.
Background: CD14+CD16++6-sulfo LacNAc (Slan)+ monocytes represent a specialized nonclassical subset with reported pro-inflammatory and regulatory features. However, their capacity to modulate classical monocytes and T lym...