Nida Kalam,Vinod R M T Balasubramaniam
Nida Kalam
Enteroviruses (EVs) lead to 10-15 million symptomatic infections each year in the United States alone. EVs enter through either the gastrointestinal or respiratory mucosa, depending on the specific virus. Since these mucosal surfaces are th...
Electroacupuncture Ameliorates Scopolamine-Induced Dry Eye Disease in Mice by Restoring Lacrimal Gland Lipid Homeostasis and Reducing IL-1β/IL-18 Expression [0.03%]
电针通过恢复泪腺脂质稳态和减少IL-1β/IL-18表达治疗东莨菪碱诱导的小鼠干眼病
Shangjie Liang,Tengyan Ji,Xia Wu et al.
Shangjie Liang et al.
Dry eye disease (DED) can lead to severe eye discomfort, which manifests as dryness, pain and decreased vision, and significantly affects daily life. This study elucidated the effects of electroacupuncture (EA) intervention on DED and clari...
Immune Divergences Between the Skin Sensitizer 2,4-Dinitrochlorobenzene and the Respiratory Sensitizer Phthalic Anhydride Revealed by Mouse Single-Cell Transcriptomics [0.03%]
基于小鼠单细胞转录组揭示的皮肤致敏剂2，4-氯苯二硝胺和呼吸系统致敏剂邻苯二甲酸酐之间的免疫差异性
Mélanie Mourot-Bousquenaud,Elsa Gratianne Guillot,Amélie Coiscaud et al.
Mélanie Mourot-Bousquenaud et al.
Background: Chemical-induced sensitization is a major health concern. To date, no internationally accepted method is able to discriminate a skin from a respiratory sensitizer. The identification of an immune profile speci...
Dynamic Balance of Histone H3 Methylation: Regulatory Mechanisms and Therapeutic Prospects in RA Immune Dysregulation and Bone Metabolism Imbalance [0.03%]
动态平衡表观遗传修饰调控类风湿关节炎免疫异常及骨代谢失衡的作用机制与治疗潜能研究
Shili Yang,Huaiquan Liu,Haiyang Kou et al.
Shili Yang et al.
Objective: To clarify the regulatory mechanisms of the dynamic balance of histone H3 methylation in rheumatoid arthritis (RA) immune dysregulation and bone metabolism imbalance, and to explore related therapeutic approach...
Artesunate Alleviates Inflammatory Injury in Neonatal Acute Respiratory Distress Syndrome Through CCL5-Mediated Pyroptosis of M2 Macrophage Subsets [0.03%]
艺术酸钠通过CCL5介导的M2型巨噬细胞焦亡减轻新生儿急性呼吸窘迫综合征的炎症损伤
Hai-Ran Ma,Yan-Mei Xie,Yu-Xuan Zhang et al.
Hai-Ran Ma et al.
Neonatal acute respiratory distress syndrome (NARDS) is a life-threatening respiratory disorder characterized by high mortality and significant long-term morbidity. Increasing evidence suggests that pyroptosis contributes to pulmonary tissu...
Targeted Clearance of Senescent Endothelium by GPNMB-Specific CAR-T Cells [0.03%]
靶向清除衰老内皮细胞的GPNMB特异性CAR-T细胞疗法
Peijie Yu,Jie Du,Yan Liu et al.
Peijie Yu et al.
Endothelial cells (ECs) serve as crucial components of blood vessels and are vital for preserving vascular health in humans. The aging of these cells significantly accelerates vascular aging. Factors released by aging ECs serve as key initi...
Development and Validation of a Multiplex Flow Cytometry-Based PBMC Assay for Immunomodulator Screening [0.03%]
用于免疫调节剂筛选的多重流式细胞术PBMC检测方法的开发与验证
Regine Brox,Holger Hackstein
Regine Brox
The identification of novel compounds capable of stimulating or suppressing immune responses is critical for advancing immunotherapy and improving our understanding of immune regulation. However, traditional screening approaches are often l...
Natural Killer Cells in Uterine Adenomyosis: Immunological Mechanisms and Therapeutic Perspectives [0.03%]
子宫腺肌症的自然杀伤细胞：免疫机制和治疗前景
Dilimulati Yalikun,Lulu Si,Hanlin Fu et al.
Dilimulati Yalikun et al.
Uterine adenomyosis (AM), a common gynecological disorder, is characterized by the invasion of endometrial glands and stroma into the myometrium, resulting in chronic pelvic inflammation and severe pain. This condition not only adversely af...
siRNA-Based Nanodrug Delivery Systems in the Treatment of Autoimmune Diseases [0.03%]
基于siRNA的纳米药物递送系统在自身免疫性疾病治疗中的应用
Yi Liu,Zhihui Feng,Biao Zhang et al.
Yi Liu et al.
Autoimmune diseases are chronic disorders with complex pathogenesis. Immune homeostasis disruption is closely associated with disease initiation and progression. Despite extensive research, the precise mechanisms underlying these diseases r...
Characterization of Short Production Cycle and Nongenotoxic mRNA-Based CAR-T Cells Targeting CD19-Positive and CD22-Positive Malignancies [0.03%]
一种短周期、非基因毒性mRNA基于的CAR-T细胞疗法及其靶向CD19和CD22阳性恶性肿瘤的特征分析
Chenyun Zhang,Haizhou Liu,Hrithik Sangani et al.
Chenyun Zhang et al.
The chimeric antigen receptor (CAR) T cell therapy targeting cluster of differentiation 19 (CD19)-positive malignancies has shown considerable efficacy in clinical settings. However, the potential genotoxicity of viral-based CAR-T therapy, ...