Francesco Scaglione,Giorgio Ciprandi
Francesco Scaglione
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for respiratory infections. These drugs work by blocking two enzymes, COX-1 and COX-2, which regulate the production of prostaglandins, mediators involved in pain, fever, and i...
Sensitization of Common Allergens and Cosensitization Patterns Among Children in Guangzhou, China [0.03%]
Xiaoyin Zeng,Haiyan Wang,Xiaoying Lin et al.
Xiaoyin Zeng et al.
Background: Pediatric allergic diseases vary by region. Subtropical sensitization profiles and their clinical implications remain poorly defined. Method: ...
Xiaoling Zhou,Yunfei Zhu,Tiantian Gui et al.
Xiaoling Zhou et al.
Objectives: This study aimed to systematically investigate the dynamics changes in membrane-bound B7-H4 (mB7-H4) expression and soluble B7-H4 (sB7-H4) levels in the peripheral blood of patients with acetylcholine receptor...
Haoyue Qi,Hanxi Zhang,Qin Wang et al.
Haoyue Qi et al.
Leiomyosarcoma (LMS), one of the soft-tissue sarcomas (STSs), has a relatively higher risk of distant metastasis. This has resulted in current first-line treatments still failing to deliver satisfactory outcomes, and the current treatment o...
Cold Atmospheric Plasma Enhances Fn14 Signaling in Hair Follicle Stem Cells, Thereby Promoting the Healing of Diabetic Skin Wounds in a Mouse Model [0.03%]
冷等离子体通过增强Fn14信号促进毛乳头细胞增殖并改善糖尿病小鼠皮肤伤口愈合
Xiaoyan Zou,Lingling Peng,Mai Luo et al.
Xiaoyan Zou et al.
The healing of diabetic skin wounds is often delayed due to cellular dysfunction and oxidative stress. Recently, cold atmospheric plasma (CAP) has shown promising efficacy in treating diabetic wounds; however, its exact mechanism remains un...
HLA-G in Hematological Malignancies: Immunoregulatory Mechanisms and Implications for Immune Evasion and Immunotherapy [0.03%]
血液系统恶性肿瘤中的HLA-G：免疫调节机制及其对免疫逃逸和免疫治疗的影响
Thaís Lohana Chanel Pereira Ribeiro,Glenda Menezes Nogueira,Mateus Souza-Barros et al.
Thaís Lohana Chanel Pereira Ribeiro et al.
Human leukocyte antigen G (HLA-G) is a nonclassical major histocompatibility complex class I molecule whose increased expression has been consistently associated with unfavorable prognosis in solid tumors and has emerged as a potential immu...
Spatiotemporal Double-Edged Sword of Macrophages: Temporal Regulation of Neuroinflammation and Neurorepair in Ischemic Stroke [0.03%]
巨噬细胞的时空双刃剑作用：缺血性脑卒中后炎症反应和神经修复的时序调控机制研究
Shuwen Zhang,Xinyu Chai,Shanzhu Guo et al.
Shuwen Zhang et al.
Ischemic stroke (IS) accounts for ~85% of all stroke cases and stands as one of the leading global causes of disability and mortality. Its pathological progression is closely intertwined with intricate inflammatory responses, among which po...
Structural and Functional Alterations of MAMs and Their Immunomodulatory Roles in Sepsis-Induced Lung Injury [0.03%]
MAM结构与功能的改变及其在脓毒症诱导的肺损伤中的免疫调节作用
Yihao Wang,Jingran Yang,Xia Li
Yihao Wang
Background: Sepsis-induced acute lung injury (SI-ALI) is a major cause of morbidity and mortality among septic patients. Recent evidence highlights the role of mitochondria-associated membranes (MAMs)-specialized contact ...
Aspergillus fumigatus Gliotoxin Inhibits LC3-Associated Phagocytosis in Macrophages in a Calcium-Dependent Manner [0.03%]
烟曲霉gliotoxin通过依赖钙离子的方式抑制巨噬细胞的LC3相关吞噬作用
Yuqing Sun,Fangyan Chen,Ling Zhang et al.
Yuqing Sun et al.
As a pivotal secondary metabolite of Aspergillus fumigatus, gliotoxin (GT) has many toxicological effects on mammalian cells; however, its function on LC3-associated phagocytosis (LAP) induced by A. fumigatus in macrophages is poorly unders...