Curcumol Ameliorates Diabetic Nephropathy by Inhibiting Podocyte Ferroptosis Through the xCT/GPX4 Pathway [0.03%]
姜黄素类似物curcumol通过xCT/GPX4途径抑制肾小球足细胞铁死亡从而改善糖尿病肾病
Yue Ji,Yuqi Wu,Jingyi Tang et al.
Yue Ji et al.
Background: Diabetic nephropathy is a leading complication of diabetes mellitus and poses a significant public health challenge. Ferroptosis has emerged as a critical pathological factor that exacerbates the progression o...
Alexander Polyak,Alexander Lee,Martha Gulati
Alexander Polyak
Cardiovascular disease (CVD) remains the leading global cause of mortality, with physical activity (PA) and inactivity playing a significant role in its prevalence and outcomes. PA has been shown to substantially reduce cardiovascular and c...
Study on the Potential Mechanism of Astragaloside IV on Renoprotection in Db/Db Mice via Network Pharmacology and Experimental Validation [0.03%]
基于网络药理学和实验验证的黄芪苷IV对 db/db 小鼠肾脏保护作用机制的研究
Han Li,Baiju Wang,Hanwen Chen et al.
Han Li et al.
Background/aims: Diabetic nephropathy (DN) is a highly predominant and critical microvascular complication associated with diabetes mellitus. Astragaloside IV (AS-IV), the main active component in Radix Astragali, is asso...
The Impact of Different Oral Antidiabetic Drugs on Insulin Pump Intensive Therapy in Type 2 Diabetes Patients: A Clinical Study [0.03%]
不同口服降糖药物对2型糖尿病患者胰岛素泵强化治疗影响的临床研究
Miaoguan Peng,Yijuan Xie,Naifeng Liang et al.
Miaoguan Peng et al.
Objective: This study aimed to compare the effects of insulin pump intensive therapy alone with those of insulin pump intensive therapy combined with metformin or dapagliflozin on the time to achieve glycemic targets, tot...
Randomized Controlled Trial
Journal of diabetes research. 2026;2026(1):e9957473. DOI:10.1155/jdr/9957473 2026
Secretory Acid Sphingomyelinase in Children and Adolescents With Type 1 Diabetes [0.03%]
分泌性酸性鞘氨醇基脂酶在1型糖尿病儿童和青少年中的作用
Chiara Mameli,Alice Bolchini,Cristina Ferrigno et al.
Chiara Mameli et al.
Introduction: The activity of acid sphingomyelinase (ASMase), a key enzyme in sphingolipid metabolism, has been found to be increased in a variety of human diseases. Studies conducted on animal and cellular models showed ...
Splice Isoforms of the Apoptosis Gene BCL-X Have Opposing Effects in Diabetic Kidney Disease: Potential Treatment Target and Prognostic Value [0.03%]
凋亡基因BCL-X的剪接异构体在糖尿病肾脏疾病中具有相反的作用：潜在治疗靶点和预后价值
Megan Stevens,Monica L Ayine,Kim Gooding et al.
Megan Stevens et al.
In recent years, the importance of alternative splicing (AS) of certain genes in the nature and progression of diabetic nephropathy (DN) has been studied. We report a novel AS event observed in the diabetic kidney-AS of the apoptosis gene B...
Is Demographic Concordance Between Lifestyle Coach and Participant Associated With Participant Retention and Weight Change in the National Diabetes Prevention Program Lifestyle Change Intervention? [0.03%]
全国糖尿病预防计划生活方式干预中生活教练与参与者的人口统计一致性与参与者的随访率和体重变化有关吗？
Britney P Smart,Anna Forte,Jacquelyn Jacobs et al.
Britney P Smart et al.
Objective: The goal of this study is to explore the association between racial/ethnic, sex, and age category concordance and participant retention and weight loss among participants enrolled in the National Diabetes Preve...
Clinical Validation of Digital PCR for Precise m.3243A>G Heteroplasmy Quantification in Early-Onset Diabetes [0.03%]
用于早期发病糖尿病患者m.3243A>G杂合子定量的数字PCR临床验证研究
Xiaomu Kong,Lei Bei,Peng Gao et al.
Xiaomu Kong et al.
Background: Mitochondrial DNA m.3243A>G variant causes maternally inherited diabetes with deafness. We developed a droplet digital PCR (dPCR) assay to quantify m.3243A>G heteroplasmy and investigated its prevalence in Chi...
Impact of Stress Hyperglycemia on Long-Term Outcomes in Patients With Acute Kidney Injury Requiring Continuous Renal Replacement Therapy: A Nationwide Cohort Study [0.03%]
应激性高血糖对连续肾脏替代治疗急性肾损伤患者的长期影响——全国队列研究
Junseok Jeon,Danbee Kang,Hyejeong Park et al.
Junseok Jeon et al.
Aim: Stress hyperglycemia, occurring during stressful conditions in patients without preexisting diabetes, is associated with poor outcomes in critically ill patients. We investigated its impact on long-term outcomes in p...
Yixiao Formula Suppresses Myocardial Fibrosis Through UpregulatingmiR-133a and Downregulating TGF-β/Smads Signal Molecules [0.03%]
益效方通过上调miR-133a和下调TGF-β/Smads信号分子抑制心肌纤维化
Qiyao Zhao,Yalu Wen,Honghui Wu et al.
Qiyao Zhao et al.
Background: Yixiao formula (YXF), a traditional Chinese herbal medicine, has demonstrated clinical efficacy in alleviating symptoms of diabetic cardiomyopathy (DCM). The therapeutic mechanism underlying YXF's effects on D...