Development of a Novel Microphysiological System for Peripheral Neurotoxicity Prediction Using Human iPSC-Derived Neurons with Morphological Deep Learning [0.03%]
一种使用人iPSC来源的神经元和形态学深度学习技术的新微型生理系统在外周神经毒性预测中的开发
Xiaobo Han,Naoki Matsuda,Makoto Yamanaka et al.
Xiaobo Han et al.
A microphysiological system (MPS) is an in vitro culture technology that reproduces the physiological microenvironment and functionality of humans and is expected to be applied for drug screening. In this study, we developed an MPS for the ...
Characterization of Disinfection By-Products Originating from Residual Chlorine-Based Disinfectants in Drinking Water Sources [0.03%]
饮用水水源中余氯消毒副产物的特征分析
Dongmei Yang,Jiale Huang,Fenli Min et al.
Dongmei Yang et al.
In this study, samples from the Yangtze River, Han River, and Liangzi Lake in Wuhan City were utilized to characterize the formation of disinfection by-products (DBPs) from chlorine-based disinfection residues in drinking water sources. The...
The Detection and Analysis of Microplastics in a Typical Mountainous Drinking Water System in China [0.03%]
中国典型山区饮用水系统中微塑料的检测与分析
Chaoxing Xu,Lingzhen Pan,Linfu Zhai et al.
Chaoxing Xu et al.
Microplastics (MPs) are widely detected in urban drinking water systems. However, the presence and characteristics of MPs in mountainous drinking water systems with independent and simple filtration facilities have been overlooked. In this ...
Organophosphate Esters and Polybrominated Diphenyl Ethers in Vehicle Dust: Concentrations, Sources, and Health Risk Assessment [0.03%]
车辆灰尘中的磷酸酯和多溴联苯醚的浓度、来源及健康风险评估
Junji Wang,Jianzai Lin,Xi Zhang et al.
Junji Wang et al.
Background: The primary flame retardants in vehicles, organophosphates (OPEs) and polybrominated diphenyl ethers (PBDEs), volatilize and accumulate in the enclosed vehicle environment, posing potential health risks. Amids...
Effect of S-Allyl-L-Cysteine on Nitric Oxide and Cadmium Processes in Rice (Oryza sativa L. sp. Zhongzao35) Seedlings [0.03%]
S-烯丙基-L半胱氨酸对水稻(Oryza sativa L. sp. Zhongzao35)幼苗中一氧化氮和镉过程的影响
Xingyu Huo,Changrong Wang,Yongchun Huang et al.
Xingyu Huo et al.
Nitric oxide (NO) is an important signaling molecule involved in regulating plant processes to cope with abiotic stress. S-allyl-L-cysteine (SAC) is known to induce NO synthesis in animals. However, it is unknown whether SAC can trigger NO ...
Geoenvironmental and Health Indices to Assess the Hazardousness of Heavy Metals in Urban Dust in Schoolyards in Murcia, Spain [0.03%]
西班牙穆尔西亚学校操场表土中重金属危害性评价的地球环境与健康指标研究
María José Delgado-Iniesta,Pura Marín-Sanleandro,María Del Carmen Canca Pedraza et al.
María José Delgado-Iniesta et al.
The aim of this study was to evaluate the possible contamination of urban dust in the schoolyards of 27 schools in an urban area of the city of Murcia (SE Spain). The color and degree of magnetism, as well as the heavy metal content (Cd, Cu...
A Novel Machine Learning Model and a Web Portal for Predicting the Human Skin Sensitization Effects of Chemical Agents [0.03%]
一种用于预测化学物质的人类皮肤致敏效应的新机器学习模型和网络平台
Ricardo Scheufen Tieghi,José Teófilo Moreira-Filho,Holli-Joi Martin et al.
Ricardo Scheufen Tieghi et al.
Skin sensitization is a significant concern for chemical safety assessments. Traditional animal assays often fail to predict human responses accurately, and ethical constraints limit the collection of human data, necessitating a need for re...
Chemical-Specific T Cell Tests Aim to Bridge a Gap in Skin Sensitization Evaluation [0.03%]
化学特异的T细胞检测旨在弥补皮肤致敏评价的不足
Nele Fritsch,Marina Aparicio-Soto,Caterina Curato et al.
Nele Fritsch et al.
T cell activation is the final key event (KE4) in the adverse outcome pathway (AOP) of skin sensitization. However, validated new approach methodologies (NAMs) for evaluating this step are missing. Accordingly, chemicals that activate an un...
Vadim A Ershov,Boris G Ershov
Vadim A Ershov
The ubiquitous use of products containing AgNPs results in the entry of nanoparticles into the environment. Both nanoparticles and Ag+ released upon their oxidative dissolution have a toxic effect on living microorganisms. The antibacterial...
James Mordecai,Assad Al-Thukair,Musa M Musa et al.
James Mordecai et al.
The Kingdom of Saudi Arabia (KSA) is the leading oil-exploring and -exploiting country in the world. As a result, contamination of the environment by petroleum products (mainly hydrocarbons) is common, necessitating strategies for their rem...