Methamphetamine Exposure Induces Neuronal Programmed Necrosis by Permeabilizing Mitochondria via the RIPK1-RIPK3-MLKL Axis [0.03%]
甲基苯丙胺通过RIPK1-RIPK3-MLKL轴线使线粒体通透性增加从而诱导神经元程序性坏死
Peng Zhou,Jiankang Xuan,Weixiao Xu et al.
Peng Zhou et al.
Methamphetamine (Meth), a psychostimulant drug of the amphetamine type, is widely abused and highly neurotoxic. Meth exposure leads to neuronal necroptosis, and the mitochondrial dysfunction may be involved. However, the underlying mechanis...
Cytotoxic Effects and Micronuclei Frequency as a Biomarker of Genotoxicity in Farmers from the Municipality of Tehuacán, Puebla, Mexico [0.03%]
墨西哥普埃布拉州tehuacán市农民的细胞毒性作用及微核频数作为基因毒性的生物标志物研究
Amparo Mauricio-Gutiérrez,Didier D Ramírez-Gutiérrez,Omar Romero-Arenas et al.
Amparo Mauricio-Gutiérrez et al.
In Tehuacán, Puebla, Mexico, the agricultural sector is primarily dedicated to corn cultivation, which is reflected in the region's economy, culture, and diet. This sector follows an agro-industrial production model dependent on pesticides...
Influence of Preparation Methods on the Concentrations of Lead and Cadmium in Amanita muscaria Products [0.03%]
preparation方法对毒蝇伞中铅镉含量的影响
Michal Ordak,Wiktoria Gorecka,Pawel Konieczynski et al.
Michal Ordak et al.
In recent years, the consumption of Amanita muscaria has gained popularity as a perceived natural alternative to psychoactive substances, often promoted online for its supposed therapeutic properties. However, the safety of such preparation...
Notch Signaling Pathway Regulates Ozone-Induced Lung Circadian Rhythm Disruption [0.03%]
诺特定时信号调节臭氧引起的肺部生物钟紊乱
Xinyu Zhang,Xiaotong Jian,Xinyi Miao et al.
Xinyu Zhang et al.
Background: Ozone (O3) pollution disrupts pulmonary circadian rhythms, yet the molecular mechanisms remain elusive. The Notch signaling pathway, critical for lung homeostasis, may crosstalk with the circadian clock system...
Toxicological, Chemical, Social, and Economic Challenges Associated with PFAS and Replacement Aqueous Film-Forming Foams (AFFF) [0.03%]
与PFAS及其替代水成膜泡沫(AFFF)相关的毒理学、化学、社会和经济挑战
William S Baldwin,Michael S Bloom,Katy W Chung et al.
William S Baldwin et al.
Poly- and perfluorinated alkyl substances (PFAS) are a group of chemicals that are widely used, prevalent in the environment, associated with several toxic effects, and often have long half-lives. Their persistence and relevant toxicity are...
Involvement of Surface Receptors in the Uptake and Cellular Responses Induced by Cationic Polyamine-Based Carbon Dots in Macrophages [0.03%]
基于聚阳离子低聚胺的碳点通过细胞表面受体介导被巨噬细胞摄取及诱导免疫响应机制研究
Agathe Cerland,Ezeddine Harmouch,Mickaël Rapp et al.
Agathe Cerland et al.
Cationic polyamine-based carbon dots (CDs) are increasingly being explored for biomedical applications. These ultrasmall (
Human Biomonitoring of PCDDs, PCDFs, and PCBs in Women Living in a Southern Italy Hotspot Area [0.03%]
南部意大利环境监测热点地区人群(PBDEs、PCDFs和PCBs)的生物监测调查——以女性为研究中心
Roberto Miniero,Vittorio Abate,Annalisa Abballe et al.
Roberto Miniero et al.
Taranto is the main harbor in Southern Italy and one of the most industrialized cities in the country, largely due to the presence of a large industrial area that includes a major oil refinery, a cement plant, and the former ILVA steel fact...
Effectiveness and Remediation Mechanisms of Geo-Electrochemical Technology for Arsenic Removal in Paddy Soil from Northern Guangxi [0.03%]
广西北部稻田土壤除砷的地球化学技术有效性及调控机制研究
Yuxiong Jiang,Meilan Wen,Yao Sun et al.
Yuxiong Jiang et al.
Arsenic pollution in paddy soil is a major environmental issue, and its remediation has become a subject of broad interest. Geo-electrochemical technology has been shown to have significant potential for remediating heavy metal-contaminated...
Characterization of the Chemical Composition, Cytotoxicity, and Metabolomic Effects of PM2.5 in a Plateau City, China [0.03%]
中国高原城市PM2.5的化学成分、细胞毒性和代谢组学效应特征化研究
Mengying Li,Lijuan Qi,Xinyi Xu et al.
Mengying Li et al.
The health impacts of atmospheric fine particulate matter (PM2.5) in plateau regions have attracted concerns, along with local population growth and rapid urbanization. This study collected PM2.5 samples at summer and winter in Xining, a ci...
Utilizing Multiple Behavioral Endpoints to Identify Negative Control Chemicals in a Larval Zebrafish Behavior Assay [0.03%]
利用多个行为终点识别斑马鱼苗行为试验中的负面对照化学物质
Bridget R Knapp,Deborah L Hunter,Jeanene K Olin et al.
Bridget R Knapp et al.
Identifying reliable negative control compounds is essential for determining the sensitivity and specificity of screening assays. However, well-characterized negative controls for developmental neurotoxicity behavioral assays in larval zebr...