Flexible Multiplane Structured Illumination Microscope with a Four-Camera Detector [0.03%]
具有四个相机探测器的柔性多平面结构照明显微镜
Karl A Johnson,Daniel Noble,Rosa Machado et al.
Karl A Johnson et al.
Fluorescence microscopy provides an unparalleled tool for imaging biological samples. However, producing high-quality volumetric images quickly and without excessive complexity remains a challenge. Here, we demonstrate a four-camera structu...
Yan Li,Gengxi Lu,Qifa Zhou et al.
Yan Li et al.
Photoacoustic (PA) imaging is able to provide extremely high molecular contrast while maintaining the superior imaging depth of ultrasound (US) imaging. Conventional microscopic PA imaging has limited access to deeper tissue due to strong l...
Multi-distance frequency-domain optical measurements of coherent cerebral hemodynamics [0.03%]
基于相干光的多距离脑功能光学成像研究
Giles Blaney,Angelo Sassaroli,Thao Pham et al.
Giles Blaney et al.
We report non-invasive, bilateral optical measurements on the forehead of five healthy human subjects, of 0.1 Hz oscillatory hemodynamics elicited either by cyclic inflation of pneumatic thigh cuffs, or by paced breathing. Optical intensity...
fNIRS for Tracking Brain Development in the Context of Global Health Projects [0.03%]
基于全球健康项目的脑发育追踪的fNIRS技术
Anna Blasi,Sarah Lloyd-Fox,Laura Katus et al.
Anna Blasi et al.
Over the past 25 years, functional near-infrared spectroscopy (fNIRS) has emerged as a valuable tool to study brain function, and it is in younger participants where it has found, arguably, its most successful application. Thanks to its inf...
The Optical Effective Attenuation Coefficient as an Informative Measure of Brain Health in Aging [0.03%]
光学有效衰减系数作为评估衰老过程中脑健康的信息指标
Antonio M Chiarelli,Kathy A Low,Edward L Maclin et al.
Antonio M Chiarelli et al.
Aging is accompanied by widespread changes in brain tissue. Here, we hypothesized that head tissue opacity to near-infrared light provides information about the health status of the brain's cortical mantle. In diffusive media such as the he...
Michael R Hamblin
Michael R Hamblin
Next to cancer, Alzheimer's disease (AD) and dementia is probably the most worrying health problem facing the Western world today. A large number of clinical trials have failed to show any benefit of the tested drugs in stabilizing or rever...
Yanxiu Li,Xiaobo Xia,Yannis M Paulus
Yanxiu Li
Retinal imaging has undergone a revolution in the past 50 years to allow for better understanding of the eye in health and disease. Significant improvements have occurred both in hardware such as lasers and optics in addition to software im...
Ryan Beams,Jeremiah W Woodcock,Jeffrey W Gilman et al.
Ryan Beams et al.
We demonstrate a multimodal superresolution microscopy technique based on a phase masked excitation beam in combination with spatially filtered detection. The theoretical foundation for calculating the focus from a non-paraxial beam with an...
Matthew D Risi,Houssine Makhlouf,Andrew R Rouse et al.
Matthew D Risi et al.
Confocal fluorescence microendoscopy provides high-resolution cellular-level imaging via a minimally invasive procedure, but requires fast scanning to achieve real-time imaging in vivo. Ideal confocal imaging performance is obtained with a ...
Guided-Mode Resonance Grating with Self-Assembled Silver Nanoparticles for Surface-Enhanced Raman Scattering Spectroscopy [0.03%]
具有自组装银纳米颗粒的光栅耦合共振光栅基SERS底物
Jing Yang,Fanghui Ren,Xinyuan Chong et al.
Jing Yang et al.
We designed and fabricated guided-mode resonance (GMR) gratings on indium-tin-oxide (ITO) thin film to generate a significantly enhanced local electric field for surface-enhanced Raman scattering (SERS) spectroscopy. Ag nanoparticles (NPs) ...