In Situ Structural Characterization of Cardiomyocyte Microenvironment by Multimodal STED Microscopy [0.03%]
超分辨STED显微镜表征心肌细胞微环境结构
Zhao Zhang,Bruce Z Gao,Tong Ye
Zhao Zhang
Within the myocardium, cardiomyocytes reside in a complex and dynamic extracellular matrix (ECM) consisting of a basement membrane (BM) and interstitial matrix. The interactions between cardiomyocytes and the myocardial ECM play a critical ...
Adjunct Nondamaging Focal Laser Reduces Intravitreal Injection Burden in Diabetic Macular Edema [0.03%]
低强度焦斑激光联合玻璃体内注射治疗糖尿病黄斑水肿临床观察
Lyna Azzouz,Asad Durrani,Yunshu Zhou et al.
Lyna Azzouz et al.
This study aims to determine the impact of adjunct nondamaging focal laser therapy on the number of anti-vascular endothelial growth factor (anti-VEGF) injections and visual acuity (VA) and imaging in patients with diabetic macular edema (D...
Manmohan Singh,Achuth Nair,Salavat R Aglyamov et al.
Manmohan Singh et al.
Assessing the biomechanical properties of the cornea is crucial for detecting the onset and progression of eye diseases. In this work, we demonstrate the application of compression-based optical coherence elastography (OCE) to measure the b...
Artificial Intelligence to Aid Glaucoma Diagnosis and Monitoring: State of the Art and New Directions [0.03%]
人工智能在青光眼诊断和监测中的应用：现状与展望
Roberto Nunez,Alon Harris,Omar Ibrahim et al.
Roberto Nunez et al.
Recent developments in the use of artificial intelligence in the diagnosis and monitoring of glaucoma are discussed. To set the context and fix terminology, a brief historic overview of artificial intelligence is provided, along with some f...
Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics [0.03%]
基于生理增强的数据分析评估海拔高度对眼压及眼前节血流动力学的影响
Alice Verticchio Vercellin,Alon Harris,Aditya Belamkar et al.
Alice Verticchio Vercellin et al.
Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (pe...
Van Phuc Nguyen,Tianye Zhu,Jessica Henry et al.
Van Phuc Nguyen et al.
Photoacoustic microscopy (PAM) is an emerging retinal imaging technique that can provide high spatial resolution and high contrast of chorioretinal vessels. PAM is compatible with optical coherence tomography (OCT) and fluorescence imaging,...
Metabolic Signaling in a Theoretical Model of the Human Retinal Microcirculation [0.03%]
人类视网膜微循环理论模型中的代谢信号传导
Julia Arciero,Brendan Fry,Amanda Albright et al.
Julia Arciero et al.
Impaired blood flow and oxygenation contribute to many ocular pathologies, including glaucoma. Here, a mathematical model is presented that combines an image-based heterogeneous representation of retinal arterioles with a compartmental desc...
Flexible Multiplane Structured Illumination Microscope with a Four-Camera Detector [0.03%]
具有四个相机探测器的柔性多平面结构照明显微镜
Karl A Johnson,Daniel Noble,Rosa Machado et al.
Karl A Johnson et al.
Fluorescence microscopy provides an unparalleled tool for imaging biological samples. However, producing high-quality volumetric images quickly and without excessive complexity remains a challenge. Here, we demonstrate a four-camera structu...
Yan Li,Gengxi Lu,Qifa Zhou et al.
Yan Li et al.
Photoacoustic (PA) imaging is able to provide extremely high molecular contrast while maintaining the superior imaging depth of ultrasound (US) imaging. Conventional microscopic PA imaging has limited access to deeper tissue due to strong l...
Multi-distance frequency-domain optical measurements of coherent cerebral hemodynamics [0.03%]
基于相干光的多距离脑功能光学成像研究
Giles Blaney,Angelo Sassaroli,Thao Pham et al.
Giles Blaney et al.
We report non-invasive, bilateral optical measurements on the forehead of five healthy human subjects, of 0.1 Hz oscillatory hemodynamics elicited either by cyclic inflation of pneumatic thigh cuffs, or by paced breathing. Optical intensity...