Efficacy and safety of TAS-102 followed by regorafenib or reverse sequence in later-line treatment of metastatic colorectal cancer: a systematic review and meta-analysis [0.03%]
TAS-102后继乐伐替尼与反之顺序用于晚期转移性结直肠癌治疗的疗效和安全性：系统评价和meta分析
Bannawich Sapapsap,Sirapratch Champarhorm,Anchana Pongpun et al.
Bannawich Sapapsap et al.
Background: Trifluridine/tipiracil (TAS-102) and regorafenib are approved and widely utilized as later-line treatment options for patients with metastatic colorectal cancer (mCRC). However, the optimal sequence between th...
Advances and applications of liquid biopsy approaches in hepatopancreatobiliary (HPB) cancers: a literature review [0.03%]
液体活检技术在肝胰胆道系统癌症中的应用及进展：文献综述
Dina Hauptschein,Pedro Luiz Serrano Uson Junior,Mitesh J Borad
Dina Hauptschein
Background and objective: Hepatopancreatobiliary (HPB) cancers, including pancreatic ductal adenocarcinoma (PDAC), hepatocellular carcinoma (HCC), and cholangiocarcinoma (CCA), are among the deadliest malignancies due to ...
Benign metastasizing leiomyoma: a systematic review of diagnosis, management, and outcomes [0.03%]
良性转移性平滑肌瘤的诊断、治疗和结局的系统评价
Karolina Karoń,Natalia Szczęsny,Krzysztof Piątkowski et al.
Karolina Karoń et al.
Background: Benign metastasizing leiomyoma (BML) is a rare complication of uterine fibroids, in which benign smooth muscle tumors spread to distant sites. Due to its rarity, clinical presentation and management remain ins...
Claudin 18.2 testing in gastroesophageal and pancreatobiliary cancers: current status, clinical implications and challenges [0.03%]
克鲁兹蛋白18.2在消化道和胰胆肿瘤中的检测：现状、临床意义及挑战
Sun Mi Lee,Huamin Wang
Sun Mi Lee
Claudin (CLDN) 18.2 is a tight-junction protein predominantly expressed in normal gastric epithelium. Malignant transformation can disrupt epithelial cell polarity, resulting in the exposure and overexpression of CLDN18.2 on tumor cell surf...
A narrative review of the value of immunoinflammatory markers in the prognosis of endometrial carcinoma [0.03%]
免疫炎症标志物在子宫内膜癌预后中的价值综述式评论
Xinxin Yin,Haoyang Zhang,Sai Zhang
Xinxin Yin
Background and objective: Endometrial cancer (EC), a prevalent gynecological malignancy, poses a significant threat to women's health, rendering prognosis assessment a pivotal area of clinical research. In recent years, i...
Small cell lung cancer: a therapeutic update in the era of immunotherapy and beyond-a narrative review [0.03%]
免疫治疗时代的小细胞肺癌疗法更新及展望：综述文章
Andrés Barba,Sergio Martínez-Recio,Mikel Portu et al.
Andrés Barba et al.
Background and objective: Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy with frequent relapse and poor long-term survival. We review current and emerging therapeutic strategies across disease st...
Daniel Chun Pong Kwok,Kenneth Siu Ho Chok
Daniel Chun Pong Kwok
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its aggressive tumour biology as well as its generally poor prognosis despite advances in systemic treatment. Oncological surgery with curative intent remains the hope for a potential...
Genome-wide 5-hydroxymethylcytosine in circulating cell-free DNA reflects DNA methylation dynamics for non-invasive detection of early hepatocellular carcinoma [0.03%]
循环游离DNA全基因组5-羟甲基胞嘧啶检测动态DNA甲基化以实现非侵入性早期肝细胞癌筛查
Junya Peng,Xu Pan
Junya Peng
Background: Early hepatocellular carcinoma (HCC) remains difficult to diagnose because of its insidious and asymptomatic onset. Liquid biopsy provides a promising non-invasive approach for early tumor detection. 5-Hydroxy...
Impact of neoadjuvant chemotherapy vs. upfront surgery on survival in early-onset colorectal cancer-a single centre experience [0.03%]
新辅助化疗和前期手术对早期结直肠癌患者生存率的影响——单中心经验报告
Oluwabukunmi Modupe Salami,Hao Yi,Guangyi Liu et al.
Oluwabukunmi Modupe Salami et al.
Background: Early-onset colorectal cancer (EO-CRC) has been gaining momentum in the oncologic community and has a reputation for being overtreated. Neoadjuvant therapy has been proven to be an effective treatment for rect...
TP63 drives TKI resistance in EGFR-mutant lung cancer via ferroptosis inhibition [0.03%]
TP63通过抑制铁死亡诱导肺癌中EGFR突变阳性肿瘤对TKI产生耐药性
Kehan Li,Jiane Liu,Wenjuan Wang et al.
Kehan Li et al.
Background: The emergence of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) presents a significant obstacle in the therapeutic strategy for EGFR-mutant non-small cell lung...