Ganoderma lucidum mitigates oxidative stress and apoptosis in chlorpyrifos‑induced testicular toxicity in male rats [0.03%]
灵芝改善氯氰菊酯致大鼠睾丸毒性的氧化应激和细胞凋亡作用
Afshin Talebinasab,Farrokh Modarresi,Ebrahim Salimi-Sabour et al.
Afshin Talebinasab et al.
Chlorpyrifos (CPS) is an organophosphate pesticide known to induce oxidative stress, apoptosis, and histopathological damage in male reproductive tissues. Ganoderma lucidum (GDL), a medicinal fungus rich in bioactive polysaccharides and tri...
Inducible differentiation of buffalo (Bubalus bubalis) embryonic stem cells towards male and female germ cell-like lineages under ex vivo BMP4-mediated stimulation [0.03%]
体外BMP4诱导水牛胚胎干细胞向雌、雄配子系分化
Syed Mohmad Shah,Manmohan Singh Chauhan
Syed Mohmad Shah
Bone Morphogenetic Proteins have been reported to play important roles in developmental biology across the species. The present study investigates the role of BMP4 in inducing germ lineage development. For this purpose, buffalo ES cells wer...
Toxicological effects of fluazuron on bovine reproductive cells: Implications for fertilization, sperm quality, and oviductal integrity [0.03%]
氟虫脲对牛生殖细胞的毒理效应：受精、精子质量和输卵管完整性的影响
Anabella Andrea Campagna,Mariana Carolina Fabra,Noelia Nikoloff et al.
Anabella Andrea Campagna et al.
Fluazuron is a veterinary antiparasitic compound widely used as pour-on in cattle. However, little is known about its potential reproductive toxicity. This study aimed to evaluate the effects of fluazuron on sperm quality, bovine oviduct ep...
Recurrent pregnancy loss: Crosstalk between immune cells, decidual cells, and cellular autophagy [0.03%]
复发性妊娠丢失：免疫细胞、蜕膜细胞和细胞自噬之间的串话作用
Xingxing Yuan,Chaofan Li,Xiaoyu Zhang et al.
Xingxing Yuan et al.
Recurrent pregnancy loss (RPL), affecting ∼5 % of couples, remains idiopathic in up to 50 % of cases. This review synthesizes the multifactorial pathogenesis of RPL, emphasizing dysregulated molecular pathways, genetic polymorphisms such a...
Decoding ovarian aging in women: Cellular damage, signaling networks, and treatment frontiers [0.03%]
女性卵巢衰老的分子机理及临床干预策略展望
Shivani Ingole,Kanchan Khare,Veepin Dwivedi et al.
Shivani Ingole et al.
Ovarian aging is a significant biological process characterized by the gradual decline of ovarian function and fertility in women as they age. It is a multifaceted process that involves various molecular mechanisms. This review article delv...
Marilú Cristofoli,Flavia Maria Pia Montenegro Donoso,Mayla Magalhães de Oliveira Alcobaça et al.
Marilú Cristofoli et al.
The rhea (Rhea americana) is a docile and highly adaptable ratite with notable zootechnical potential for the production of meat, eggs, feathers, and leather. Beyond its economic relevance, captive breeding plays an important role in conser...
Controlled ovarian hyperstimulation reduces mouse embryo implantation capacity through uterine HIF-2α mediated pathway [0.03%]
控制性卵巢过度刺激通过子宫HIF-2α介导的途径降低小鼠胚胎着床能力
Zheng Zhi,Haijun Yang,Zhangming Liu et al.
Zheng Zhi et al.
Controlled ovarian hyperstimulation (COH) is a cornerstone of assisted reproductive technologies, yet its effects on endometrial function and embryo implantation remain poorly understood, particularly regarding the role of hypoxia-inducible...
Analyzing the toxicological effects of PET-MPs on male infertility: Insights from network toxicology, mendelian randomization, and transcriptomics [0.03%]
PET微塑料对男性不育毒理效应的网络毒理学、孟德尔随机化及转录组学生物信息学综合分析研究
Yang Yang,Linfeng Li,Ning Zhang et al.
Yang Yang et al.
Current research indicates that polyethylene terephthalate microplastics (PET-MPs) may significantly impair male reproductive function. This study aimed to investigate the potential molecular mechanisms underlying this impairment. Potential...
Pasteurized Akkermansia muciniphila ameliorates insulin resistance by reducing placental inflammation in GDM mouse model [0.03%]
巴氏消毒剂Akkermansia muciniphila通过减少GDM小鼠模型的胎盘炎症来改善胰岛素抵抗
Yi Wang,Yuting Zhu,Yan Cui et al.
Yi Wang et al.
Gestational diabetes mellitus (GDM) is a common and serious complication during pregnancy. Depleted next-generation probiotic, Akkermansia muciniphila (AKK) in GDM women indicates its potential on GDM prevention. However, the functions and ...
Evaluation of the protective effect of resveratrol-loaded solid lipid nanoparticles on radiation- or doxorubicin-induced spermatogenic damage in mice [0.03%]
白藜芦醇固脂纳米粒对小鼠放射或阿霉素致生精细胞损伤保护作用的评价研究
Mohammad Farhadi Rad,Faranak Aghaz,Khodabakhsh Rashidi et al.
Mohammad Farhadi Rad et al.
Radiation and doxorubicin (Dox) exert destructive effects on testicular tissue. Resveratrol, a natural antioxidant, may protect the spermatogenic system against the toxic effects of these agents. This study evaluated the protective and anti...