Downregulation of intracellular ATP levels by PANX1 inhibits ovarian granulosa cell proliferation and mediates follicular dysplasia in elderly women [0.03%]
PANX1通过下调细胞内ATP水平抑制卵巢颗粒细胞增殖并介导老年女性卵泡发育异常
Zhiqin Zhang,Xuechen Sun,Xin Li et al.
Zhiqin Zhang et al.
This study examined pannexin 1 (PANX1) expression in ovarian granulosa cells of women with advanced maternal age and its role in cell proliferation and apoptosis, aiming to clarify mechanisms of age-related follicular dysplasia. Ninety wome...
Genotypic and metabolic impact of the SOD1 I>D polymorphism in polycystic ovary syndrome [0.03%]
多囊卵巢综合征中SOD1 I/D多态性的基因型和代谢影响
Mehmet Can Nacar,Recai Aci̇,Şengül Tural et al.
Mehmet Can Nacar et al.
This study aimed to investigate the association between the SOD1 gene I>D polymorphism, a key component of the antioxidant defense system, and polycystic ovary syndrome (PCOS), as well as to evaluate the potential effects of this genetic va...
Huamei Ju,Ziliang Geng,Binyan Chen et al.
Huamei Ju et al.
The heterotrimeric complex serine-threonine protein phosphatase 2 A (PP2A) is integral to the regulation of essential cellular processes. It is particularly crucial in spermatogenesis, where it is indispensable for meiosis, mitosis, sperm c...
Effect of exogenous melatonin on the testes of Wistar rats undergoing early weaning [0.03%]
外源性褪黑素对早期断奶大鼠睾丸的影响
José Anderson da Silva Gomes,Renan Gabriel da Silva Ferreira,Jennyfer Martins de Carvalho et al.
José Anderson da Silva Gomes et al.
The aim of the present study was to investigate the activity of exogenous melatonin as a potential agent in reversing testicular structural damage induced by early weaning. For this purpose, Wistar rats were used and divided into four exper...
Morphokinetic assessment of the blastocyst's trophectoderm re-expansion post-warming: predictive markers for clinical pregnancy in ART [0.03%]
胚胎玻璃化冷冻复苏后囊胚滋养层的二次扩张：体外受精妊娠的预测指标
Rossella Fucci,Irene Oliva,Arianna Marcellini et al.
Rossella Fucci et al.
To date, the Gardner Grading System remains the gold standard for the conventional evaluation of blastocysts. However, the use of Time-lapse technology in Assisted Reproductive Technologies (ART) cycles provides a dynamic, morphokinetic ass...
Prediction of euploidy and probability of obtaining target number of euploid embryos through preimplantation genetic testing for aneuploidy [0.03%]
胚胎植入前遗传学筛查非整倍体后的整倍体预测及获取目标整倍体胚胎的概率预测
Kazuma Onishi,Daichi Inoue,Yuta Kida et al.
Kazuma Onishi et al.
We aimed to develop prediction models estimating (1) the probability of obtaining a target number of euploid embryos per individual and (2) the probability of euploidy at the embryo level using data from preimplantation genetic testing for ...
The mouse model of induced sperm DNA damage caused by polystyrene microplastics exhibited distinct transcriptomic and proteomic features [0.03%]
聚苯乙烯微塑料诱导小鼠精子DNA损伤的基因表达和蛋白变化特征研究
Chenming Zhang,Xiaofei Han,Yifei Wang et al.
Chenming Zhang et al.
Polystyrene microplastics (PS-MPs) are extensively utilized in plastic goods worldwide. The ingestion of PS-MPs has resulted in a high rate of DNA fragmentation index (DFI), which can potentially result in infertility and recurrent spontane...
Phloretin enhances the efficiency of sheep oocyte IVM and early embryonic development by bolstering antioxidant defenses, inhibiting apoptosis, and promoting development [0.03%]
茋通过增强抗氧化防御、抑制凋亡和促进发育来提高羊卵母细胞体外成熟和早期胚胎发育的效率
Xu Li,Shuhong Tang,Yinwei Zheng et al.
Xu Li et al.
Phloretin, a natural dihydrochalcone flavonoid, is recognized for its potent antioxidant, anti-apoptotic, and anti-inflammatory properties. This study investigated the effects of phloretin on the in vitro maturation (IVM) of sheep oocytes a...
Annatto concentrate supplementation improves systemic redox balance and modulates placental FGF-2 expression in ewes [0.03%]
红树胶浓缩物补充改善母羊的全身氧化还原平衡并调节胎盘FGF-2表达
Leonardo Lima Salata,Calie Castilho,Isabella Guartieri da Silva et al.
Leonardo Lima Salata et al.
Annatto (Bixa orellana) carotenoids have antioxidant potential, but effects on placental biology and antioxidant parameters in ewes are unclear. We tested whether dietary annatto concentrate (ANC) in late gestation modulates immediate-postp...
Emerging role and interplay of programmed cell death in endometritis: Insights into mechanisms and therapeutic targets [0.03%]
子宫内膜炎中程序性细胞死亡的作用及相互作用：机制和治疗靶点的启示
Islam Ahmed Abdelmawgood,Dina M M Kotb,Ahmed Ezzat Mostafa et al.
Islam Ahmed Abdelmawgood et al.
Endometritis is the inflammation of the endometrial lining, frequently linked to pelvic pain. Endometritis is significantly associated with postpartum problems, including infertility. Programmed cell death (PCD) is a genetically regulated m...