Response of the mTOR signaling pathway to the reproductive dysfunction of dysbiosis-induced male mice [0.03%]
菌群失调诱导的雄性小鼠生殖功能障碍对mTOR信号通路的影响响应研究
Malavi Arachchi Gamage Nayodya Dananjanee Malavi Arachchi Gamage,Wijesooriya Mudhiyanselage Nadeema Dissanayake,Young-Joo Yi
Malavi Arachchi Gamage Nayodya Dananjanee Malavi Arachchi Gamage
The mammalian target of rapamycin (mTOR) signaling pathway plays a key role in coordinating several cellular activities in response to environmental signals, thereby influencing metabolism and reproduction. This study aimed to determine the...
"Alpha ketoglutarate mediated regulation of maturation and oxidative balance" in OPU derived Bos indicus oocytes [0.03%]
α-酮戊二酸介导的OPU回收瘤牛卵母细胞成熟和氧化平衡调节机制研究
Rele Gauri Shrikant,V S Chouhan,Chinmay Warghat et al.
Rele Gauri Shrikant et al.
Alpha-Ketoglutarate (AKG), a pivotal metabolite in the tricarboxylic acid cycle, possesses notable antioxidant properties that reduce oxidative stress. While its benefits in in-vitro maturation (IVM) of porcine, murine, and ovine oocytes ar...
Effect of seasons on cryopreserved sperm quality and subsequent fertility in Ouled Djellal rams [0.03%]
季节对Ouled Djellal种公羊冻精品质及后续受精能力的影响
Asmaa Sayah,Karim Benhenia,Ourida Rahal et al.
Asmaa Sayah et al.
This study aimed to investigate the effect of seasons on sperm cryopreservation and fertility outcomes in Ouled Djellal rams. For this purpose, sperm samples were collected from five fertile rams during winter, spring, summer and autumn and...
Effect of ginger extract and/or fenofibrate on the associated infertility of experimentally induced obese Wistar Albino male rats [0.03%]
姜提取物和/或非诺贝特对实验性肥胖大鼠相关不育的影响
Mohamed H Mohamed,Samia M Abd El-Rheem,Essam A Almadaly et al.
Mohamed H Mohamed et al.
This study explores the effects of oral administration of ginger and/or fenofibrate on infertility in experimentally induced obese male rats. Fifty male rats were divided into five (n = 10) groups as follows: the normal control (NC), high-f...
Recent advances in progesterone receptor-targeted therapy for uterine fibroids: A systematic review of synthetic and natural modulators [0.03%]
黄体酮受体靶向治疗子宫肌瘤的最新研究进展：合成和天然调节剂的系统性综述
Hendike Yuniar Purnamasari,Ratika Rahmasari,Aini Gusmira et al.
Hendike Yuniar Purnamasari et al.
Progesterone receptor (PR) signaling plays a pivotal role in uterine fibroids (UFs) development and progression. Selective progesterone receptor modulators (SPRMs) and plant-derived PR modulators have emerged as promising therapeutic strate...
Artificial ovary systems for fertility preservation: Current advances, bioengineering strategies, and translational perspectives [0.03%]
人工卵巢系统在生育力保存中的应用：目前的进展、生物工程策略和转化视角
Anca Huniadi,Viorela-Romina Murvai,Ioana Alexandra Zaha et al.
Anca Huniadi et al.
Ovarian insufficiency is a significant cause of infertility and endocrine problems in women, especially after premature ovarian failure or gonadotoxic cancer treatments. Traditional fertility preservation methods, such as oocyte and ovarian...
Epimedium polysaccharide alleviates adenine-induced oligoasthenozoospermia in mice by inhibiting ferroptosis and inflammation through TLR4/NF-κB and SLC7A11/GPX4 axis [0.03%]
淫羊藿多糖通过TLR4/NF-кB和SLC7A11/GPX4轴抑制铁死亡和炎症缓解腺嘌呤致小鼠少弱精子症的研究
Kun-Yang Tang,Wang Ai,Xiao-Cui Jiang et al.
Kun-Yang Tang et al.
This study aimed to investigate the effects and mechanisms of Epimedium polysaccharide (EP) on ferroptosis in oligoasthenozoospermia (OAT) mice through the TLR4/NF-κB and SLC7A11/GPX4 signaling pathways. KM mice were administered adenine v...
Proteomic insights into the effects of cryopreservation on sperm of endangered Eld's deer (Rucervus eldii) [0.03%]
蛋白质组学揭示克氏鹿(Rucervus eldii)冷冻保存对精子影响的见解
Monsicha Nijaran,Sittiruk Roytrakul,Narumon Phaonakrop et al.
Monsicha Nijaran et al.
The success of fertilization largely depends on semen quality. However, semen cryopreservation can impair sperm function and reduce conception rates, thereby hindering the repopulation of threatened species, including Eld's deer (Rucervus e...
Silencing fatty acid binding protein 5 inhibits prostaglandin E2 and activates CD8 T cells in castration-resistant prostate cancer [0.03%]
沉默脂肪酸结合蛋白5可抑制前列腺癌去势抵抗性前列腺癌前列腺素E2并激活CD8T细胞
Jun Song,Jiayu Tang,Jun Cai et al.
Jun Song et al.
Prostate cancer (PCa) frequently progresses to incurable castration-resistant prostate cancer (CRPC) following androgen deprivation therapy. The immunosuppressive tumor microenvironment limits the efficacy of immunotherapy in CRPC. Fatty ac...
An early-onset preeclampsia study of C19MC: DNA methylation in the spermatozoa and, DNA methylation and expression in the placental villi [0.03%]
C19MC小鼠模型早期子痫前期研究：精子DNA甲基化和胎盘绒毛DNA甲基化及表达分析
Sweta Nair,Shaini Joseph,Himangi Warke et al.
Sweta Nair et al.
Abnormal paternal methylation of imprinted genes is associated with preeclampsia. C19MC is an imprinted miRNA cluster that plays an important role in placental development. Thus, the present study investigated methylation of C19MC in the sp...