Cryptorchidism-induced disruption of TRPM8 expression and calcium signaling in canine testes: A potential mechanism for tumourigenesis [0.03%]
隐睾导致犬睾丸中TRPM8表达及钙信号紊乱：一种潜在的致瘤机制
Anna Gałuszka,Wojciech Łopuszyński,Patrycja Kurowska et al.
Anna Gałuszka et al.
Cryptorchidism is a condition where one or both testes fail to descend, increasing the risk of tumour development. This study investigated histological and molecular changes in canine cryptorchid testes, focusing on the TRPM8 calcium channe...
Use of an exogenous DNA-free system to generate MSTN-KO calves by CRISPR/Cas9 and SCNT [0.03%]
利用CRISPR/Cas9和体细胞核移植技术构建无外源DNA整合的MSTN基因敲除牛体系
Mariana Suvá,Juan Ignacio Bastón,Elisabet Astrid Wiedenmann et al.
Mariana Suvá et al.
This study aimed to obtain myostatin (MSTN)-knockout calves, while avoiding the risk of exogenous DNA integration during gene editing. To achieve this, we combined CRISPR/Cas9 ribonucleoprotein gene editing with somatic cell nuclear transfe...
Ewelina Trela-Kobędza,Anna Ajduk
Ewelina Trela-Kobędza
The number of pollutants stemming from anthropogenic chemicals is increasing every year. Some of them act similarly to hormones and are referred to as endocrine-disrupting chemicals or endocrine disruptors. In this group, bisphenol A (BPA) ...
Evaluation of the relative gene expression of FGF2, HAS2, BCL2, VEGFA, and PGR in repeat-breeder cows undergoing cyclicity or acyclicity [0.03%]
用于评估周期性和非周期性再生母牛中FGF2、HAS2、BCL2、VEGFA和PGR基因表达相对水平的分析方法
Punnawut Yama,Napatsorn Montha,Jakree Jitjumnong et al.
Punnawut Yama et al.
Repeat breeder syndrome (RBS) is one of the main reproductive failures in mono-ovulatory dairy cattle. The differential relative expression of several important genes in the ovary and uterus were evaluated in repeat-breeder dairy cattle. Co...
The postnatal offspring of finasteride-treated male rats show altered ERα and PCNA expression in the liver [0.03%]
接受非那雄胺处理的雄性大鼠产后子代肝中雌激素受体α和增殖细胞核抗原表达改变
Agnieszka Kolasa,Paulina Kur,Sylwia Rzeszotek et al.
Agnieszka Kolasa et al.
A growing body of data indicates that the physiology of the liver is sex-hormone dependent, with some types of liver failure occurring more frequently in males, and some in females. In males, in physiological conditions, estrogens acts via ...
Summarizing the human genes and their variants causative of non-obstructive azoospermia uncovered using whole genome/exome sequencing [0.03%]
全基因组或外显子组测序发现的人类非梗阻性无精子症相关基因及其变异的总结
Rim Ibrahim,Agnieszka Malcher,Maciej Kurpisz
Rim Ibrahim
Azoospermia represents 15 % of male infertility cases and is characterized by the total absence of sperm cells in the ejaculate. Recent studies on non-obstructive azoospermia (NOA) underline the significance of genetic diagnosis such as who...
Trps1 targets Scarb1 to regulate cholesterol acquisition in mouse Leydig cells [0.03%]
TRPS1靶向SCRAP1调节小鼠支持细胞胆固醇获得
Xiuli Lian,Zihang Lin,Weitao Hu et al.
Xiuli Lian et al.
Approximately 7 % of men are suffering from infertility, accounting for 40 %-50 % of all cases of all infertility, and low testosterone levels are closely associated with male infertility. Our previous study indicated that transcriptional r...
Physical activity pattern and Pre-eclampsia risk biomarkers: an observational study [0.03%]
一项观察性研究：身体活动模式与子痫前期风险生物标志物的关系
Ana M Cagiao,Pablo Díaz-Brage,Manuel-Avelino Giráldez et al.
Ana M Cagiao et al.
Screening tests for preterm pre-eclampsia (PE) include maternal risk factors, mean arterial blood pressure (MAP), uterine artery pulsatility index (UtA-PI) and serum placental growth factor (PlGF). Exercise interventions have been shown to ...
Frequent use of methylphenidate causes reduction in sperm production and sperm quality in adult balb/c mice [0.03%]
甲基苯丙胺使用致BALB/C小鼠精子发生障碍及精子质量下降
Grasielle Avelar Vieira Rodrigues,Fernanda Carolina Ribeiro Dias,Elizabeth Lopes de Oliveira et al.
Grasielle Avelar Vieira Rodrigues et al.
Methylphenidate is a psychostimulant used mainly in the treatment of attention deficit hyperactivity disorder (ADHD). The present study evaluated the effects of the drug on the testicles of adult mice, through morphological, histometric, ho...
Morpho-functional and biochemical improvements in ram spermatozoa following intraepididymal platelet-rich plasma administration [0.03%]
富血小板血浆附睾内给药对公羊精子形态、功能和生化指标的影响
Serap Dayan Cinkara,Nida Badıllı,İbrahim Halil Güngör et al.
Serap Dayan Cinkara et al.
This study evaluated the effects of intraepididymal platelet-rich plasma (PRP) administration on sperm morpho-functional characteristics and biochemical profiles in rams. Twelve healthy one-year-old Akkaraman rams were randomly assigned to ...