Recent advances in progesterone receptor-targeted therapy for uterine fibroids: A systematic review of synthetic and natural modulators [0.03%]
Hendike Yuniar Purnamasari,Ratika Rahmasari,Aini Gusmira et al.
Hendike Yuniar Purnamasari et al.
Progesterone receptor (PR) signaling plays a pivotal role in uterine fibroids (UFs) development and progression. Selective progesterone receptor modulators (SPRMs) and plant-derived PR modulators have emerged as promising therapeutic strate...
Artificial ovary systems for fertility preservation: Current advances, bioengineering strategies, and translational perspectives [0.03%]
Anca Huniadi,Viorela-Romina Murvai,Ioana Alexandra Zaha et al.
Anca Huniadi et al.
Ovarian insufficiency is a significant cause of infertility and endocrine problems in women, especially after premature ovarian failure or gonadotoxic cancer treatments. Traditional fertility preservation methods, such as oocyte and ovarian...
Epimedium polysaccharide alleviates adenine-induced oligoasthenozoospermia in mice by inhibiting ferroptosis and inflammation through TLR4/NF-κB and SLC7A11/GPX4 axis [0.03%]
淫羊藿多糖通过TLR4/NF-кB和SLC7A11/GPX4轴抑制铁死亡和炎症缓解腺嘌呤致小鼠少弱精子症的研究
Kun-Yang Tang,Wang Ai,Xiao-Cui Jiang et al.
Kun-Yang Tang et al.
This study aimed to investigate the effects and mechanisms of Epimedium polysaccharide (EP) on ferroptosis in oligoasthenozoospermia (OAT) mice through the TLR4/NF-κB and SLC7A11/GPX4 signaling pathways. KM mice were administered adenine v...
Proteomic insights into the effects of cryopreservation on sperm of endangered Eld's deer (Rucervus eldii) [0.03%]
蛋白质组学揭示克氏鹿(Rucervus eldii)冷冻保存对精子影响的见解
Monsicha Nijaran,Sittiruk Roytrakul,Narumon Phaonakrop et al.
Monsicha Nijaran et al.
The success of fertilization largely depends on semen quality. However, semen cryopreservation can impair sperm function and reduce conception rates, thereby hindering the repopulation of threatened species, including Eld's deer (Rucervus e...
Silencing fatty acid binding protein 5 inhibits prostaglandin E2 and activates CD8 T cells in castration-resistant prostate cancer [0.03%]
沉默脂肪酸结合蛋白5可抑制前列腺癌去势抵抗性前列腺癌前列腺素E2并激活CD8T细胞
Jun Song,Jiayu Tang,Jun Cai et al.
Jun Song et al.
Prostate cancer (PCa) frequently progresses to incurable castration-resistant prostate cancer (CRPC) following androgen deprivation therapy. The immunosuppressive tumor microenvironment limits the efficacy of immunotherapy in CRPC. Fatty ac...
An early-onset preeclampsia study of C19MC: DNA methylation in the spermatozoa and, DNA methylation and expression in the placental villi [0.03%]
C19MC小鼠模型早期子痫前期研究：精子DNA甲基化和胎盘绒毛DNA甲基化及表达分析
Sweta Nair,Shaini Joseph,Himangi Warke et al.
Sweta Nair et al.
Abnormal paternal methylation of imprinted genes is associated with preeclampsia. C19MC is an imprinted miRNA cluster that plays an important role in placental development. Thus, the present study investigated methylation of C19MC in the sp...
Oocyte-intrinsic aging drives whole-chromosome aneuploidy independent of ovarian reserve beyond maternal age as risk factor [0.03%]
卵母细胞内在老化独立于卵巢储备驱动整倍体非整倍性变化而非高龄产妇的风险因素
Pham Thi Hai Ha,Mai Vuong Hung,Nguyen Khac Han Hoan et al.
Pham Thi Hai Ha et al.
This retrospective cross-sectional study investigated whether maternal age functions as an independent risk factor for chromosomal aneuploidy in day-5 blastocysts through oocyte-intrinsic aging mechanisms rather than quantitative ovarian re...
Integrative assessment of gamete and embryo quality in porcine in vitro production: A comprehensive review [0.03%]
猪体外受精综合评估：全面综述
Victoria Slezec-Frick,Guillaume Lenoir,Loris Commin et al.
Victoria Slezec-Frick et al.
Despite significant progress in porcine in vitro embryo production (IVP), major challenges persist, particularly regarding the biological quality and developmental competence of gametes and embryos produced in vitro. The lack of standardise...
Patterns of cell exclusion in human embryos reveal a stage-dependent association with the detection of fetal heartbeat within fresh cycles [0.03%]
人类胚胎的细胞排除模式揭示了与新鲜周期中胎儿心跳检测的阶段依赖性联系
Radhika Kakulavarapu,Aleksej Stevanovic,Mario Iliceto et al.
Radhika Kakulavarapu et al.
Cell exclusion (CE) is a morphological phenomenon observed and characterized relative to embryo morulation, yet its implications for reproductive competence seem heterogeneous. This study investigated whether variability in reproductive suc...
Temporal characterization of conditions that promote functional capacitation of stallion sperm [0.03%]
促进公马精子功能获能的条件的时间特征分析
Joao D de Agostini Losano,Jillian E Guertin,Maura S McGraw et al.
Joao D de Agostini Losano et al.
Equine in vitro fertilization (IVF) has historically been challenged due to lack of conditions that promote functional capacitation of stallion sperm. Capacitation success is often attributed to prolonged sperm incubation requirements. Adva...