Frailty and Mobility [0.03%]
衰弱与活动能力下降
Eamonn Eeles,Nancy Low Choy
Eamonn Eeles
Frailty represents a state of heightened vulnerability. Mobility impairment contributes to the construct of frailty and channels adverse events. While mobility disorder is universal at a high burden of frailty, neither mobility nor balance ...
Hospital Care for Frail Elderly Adults: From Specialized Geriatric Units to Hospital-Wide Interventions [0.03%]
脆弱老年患者的医院护理：从专科老年病科到全院介入式护理模式
Franka C Bakker,Marcel G M Olde Rikkert
Franka C Bakker
Much of the acute care provided in hospitals is for elderly people. Frailty is a common clinical condition among these patients. Frail patients are vulnerable to undergoing adverse events, to developing geriatric syndromes and to experienci...
Frailty in Primary Care [0.03%]
初级保健中的衰弱症
Roman Romero-Ortuno
Roman Romero-Ortuno
This chapter considers the pragmatic integration of frailty in primary care. While some patients present to primary care practitioners with relatively well-defined problems that can be managed by a single intervention and/or organ-specific ...
Comparison and Clinical Applications of the Frailty Phenotype and Frailty Index Approaches [0.03%]
衰弱表型和衰弱指数的比较及临床应用
Olga Theou,Kenneth Rockwood
Olga Theou
The previous chapter focused on the conceptualization and operationalization of the deficit accumulation and phenotypic approaches to the description of frailty. The purpose of this chapter is to summarize some studies that compared these m...
Operationalizing Frailty Using the Frailty Phenotype and Deficit Accumulation Approaches [0.03%]
应用衰弱表型和缺陷积累方法操作化衰弱
Olga Theou,Jeremy Walston,Kenneth Rockwood
Olga Theou
In both demographic and clinical studies, frailty is understood as a multidimensional state of increased vulnerability compared with the status of others of the same age. Of the many theoretical definitions of frailty, two are commonly empl...
Frailty and the Microbiome [0.03%]
脆弱性与微生物组
Conor J Meehan,Morgan G I Langille,Robert G Beiko
Conor J Meehan
From the moment of birth, the human body plays host to a rich diversity of microbes. Body sites such as the skin, the gut and the mouth support communities of microorganisms (collectively known as the microbiome) that are both numerous and ...
Sex Differences in Frailty [0.03%]
脆弱性的性别差异
Ruth E Hubbard
Ruth E Hubbard
Although women live longer lives than men, they tend to have poorer health status. Here, we review the biological and socio-behavioral factors that may contribute to this sex-frailty paradox. The conceptual framework that frailty is a produ...
Tamas Fulop,Janet McElhaney,Graham Pawelec et al.
Tamas Fulop et al.
Frailty is a still-evolving concept of a complex phenomenon. There are several algorithms and strategies for assessing frailty syndrome, but currently, no universally accepted definition or measurement protocol has been determined. Conseque...
Susan E Howlett
Susan E Howlett
Animal models have contributed greatly to our understanding of the biology of aging and have been used to test new potential interventions to enhance survival. However, whether these interventions can modify frailty in animals is not yet cl...
Kenneth Rockwood,Arnold Mitnitski,Susan E Howlett
Kenneth Rockwood
Cells age in association with deficit accumulation via mechanisms that are far from fully defined. Even so, how deficits might scale up from the subcellular level to give rise to clinically evident age-related changes can be investigated. T...