Aleksander V Drozdetski,Abhishek Mukhopadhyay,Alexey V Onufriev
Aleksander V Drozdetski
The strong bending of polymers is poorly understood. We propose a general quantitative framework of polymer bending that includes both the weak and strong bending regimes on the same footing, based on a single general physical principle. As...
Thermodynamic Integration in 3n Dimensions without Biases or Alchemy for Protein Interactions [0.03%]
无偏三维热力学积分在蛋白质相互作用中的应用
Liao Y Chen
Liao Y Chen
Thermodynamic integration (TI), a powerful formalism for computing Gibbs free energy, has been implemented for many biophysical processes with alchemical schemes that require delicate human efforts to choose/design biasing potentials for sa...
Ultrasound neuromodulation: mechanisms and the potential of multimodal stimulation for neuronal function assessment [0.03%]
超声神经调控：机制及其在神经功能评估中的多模态刺激潜力
Hermes A S Kamimura,Allegra Conti,Nicola Toschi et al.
Hermes A S Kamimura et al.
Focused ultrasound (FUS) neuromodulation has shown that mechanical waves can interact with cell membranes and mechanosensitive ion channels, causing changes in neuronal activity. However, the thorough understanding of the mechanisms involve...
Application of the Brown dynamics fluctuation-dissipation theorem to the study of Plasmodium berghei transporter protein PbAQP [0.03%]
布朗动力学波动耗散定理在恶性疟原虫转运蛋白PbAQP研究中的应用
Liao Y Chen
Liao Y Chen
In this article, the Brownian dynamics fluctuation-dissipation theorem (BD-FDT) is applied to the study of transport of neutral solutes across the cellular membrane of Plasmodium berghei (Pb), a disease-causing parasite. Pb infects rodents ...
Temporal stability of lipid-shelled microbubbles during acoustically-mediated blood-brain barrier opening [0.03%]
声学介导的血脑屏障开放过程中脂质壳微气泡的稳定性研究
Antonios N Pouliopoulos,Daniella A Jimenez,Alexander Frank et al.
Antonios N Pouliopoulos et al.
Non-invasive blood-brain barrier (BBB) opening using focused ultrasound (FUS) is being tested as a means to locally deliver drugs into the brain. Such FUS therapies require injection of preformed microbubbles, currently used as contrast age...
MutS α's Multi-Domain Allosteric Response to Three DNA Damage Types Revealed by Machine Learning [0.03%]
机器学习揭示错配修复蛋白MutSα对三种DNA损伤类型多结构域别构响应机制
Ryan L Melvin,William G Thompson,Ryan C Godwin et al.
Ryan L Melvin et al.
MutSα is a key component in the mismatch repair (MMR) pathway. This protein is responsible for initiating the signaling pathways for DNA repair or cell death. Herein we investigate this heterodimer's post-recognition, post-binding response...
Yaghoub Dabiri,Alex Van der Velden,Kevin L Sack et al.
Yaghoub Dabiri et al.
The goal of this paper was to provide a real-time left ventricular (LV) mechanics simulator using machine learning (ML). Finite element (FE) simulations were conducted for the LV with different material properties to obtain a training set. ...
Crowding Induces Entropically-Driven Changes to DNA Dynamics That Depend on Crowder Structure and Ionic Conditions [0.03%]
拥挤通过离子条件和 crowder 结构决定的脱氧核糖核酸动力学熵驱动变化诱导而来
Warren M Mardoum,Stephanie M Gorczyca,Kathryn E Regan et al.
Warren M Mardoum et al.
Macromolecular crowding plays a principal role in a wide range of biological processes including gene expression, chromosomal compaction, and viral infection. However, the impact that crowding has on the dynamics of nucleic acids remains a ...
Mechanical Proofreading: A General Mechanism to Enhance the Fidelity of Information Transfer Between Cells [0.03%]
机械校对：提高细胞间信息传递保真度的通用机制
Joshua M Brockman,Khalid Salaita
Joshua M Brockman
The cells and receptors of the immune system are mechanically active. Single molecule force spectroscopy, traction force microscopy, and molecular tension probe measurements all point to the importance of piconewton (pN) molecular forces in...
Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies [0.03%]
点亮数字：整合数学模型以优化光医学剂量学和联合疗法
Bryan Q Spring,Ryan T Lang,Eric M Kercher et al.
Bryan Q Spring et al.
Cancer photomedicine offers unique mechanisms for inducing local tumor damage with the potential to stimulate local and systemic anti-tumor immunity. Optically-active nanomedicine offers these features as well as spatiotemporal control of t...