AI-assisted quantitative analysis for evaluating melanin distribution in 3D pigmented epidermis-on-a-chip models [0.03%]
人工智能辅助的三维色素皮肤芯片模型中黑色素分布评价的定量分析方法
Yu Yao,Xuan Du,Yanhui Li et al.
Yu Yao et al.
Introduction: Abnormal pigmentation plays an important role in various skin diseases and in studies of whitening efficacy.Three-dimensional pigmented epidermis-on-a-chip models provide a crucial in vitro platform for expl...
Histological fidelity and microenvironmental kinome signatures of metastatic patient-derived organoids [0.03%]
组织学保真度和微环境激酶组特征的患者衍生器官类器官转移模型
Joana Leitão-Castro,Alexia Melanie Lopresti,Kamilla Westarp Zornhagen et al.
Joana Leitão-Castro et al.
Metastatic cancer remains the greatest clinical challenge due to ineffective treatments and limited reliable models for drug testing. Patient-derived organoids (PDOs) and their subsequent culture as patient-derived-organoid xenograft (PDOX)...
Kidney-targeted drug delivery: from physiological mechanisms to precision therapeutics [0.03%]
肾脏靶向药物递送：从生理机制到精准治疗
Zhanyi Tan,Yuan Hu,Yajun Wu et al.
Zhanyi Tan et al.
Chronic kidney disease (CKD) and acute kidney injury (AKI) remain critical global health challenges, yet effective pharmacotherapies are severely limited by poor renal bioavailability and off-target systemic toxicity. Overcoming these obsta...
Valentin von Werz,Aleksander Szarzynski,Matthias Hadrbolec et al.
Valentin von Werz et al.
Natural killer cells are emerging as promising "off-the-shelf" effectors for cancer immunotherapy, yet expansion of the NK-92 cell line in batch cultivation leads to rapid loss of cytotoxicity concomitant with lactate accumulation. In this ...
Correction: PDGF-BB overexpressing dental pulp stem cells improve angiogenesis in dental pulp regeneration [0.03%]
牙髓干细胞过表达PDGF-BB促进牙髓再生中血管生成纠正意见
Wentao Jiang,Shuhan Duan,Weiping Li et al.
Wentao Jiang et al.
[This corrects the article DOI: 10.3389/fbioe.2025.1578410.]. Keywords: dental pulp regeneration; dental pul...
Lightweight design of running prosthetic feet using honeycomb sandwich composites: a comparative FEA study [0.03%]
一种用于跑步假肢脚的蜂窝夹芯复合材料轻量化设计：一种比较有限元分析研究方法
Yunis Akkaş,Serap Alsancak
Yunis Akkaş
Introduction: Honeycomb sandwich composites are widely employed in aerospace and structural applications due to their high specific strength and efficient energy storage and return, offering a promising design alternative...
A biohybrid nanovesicle hijacks inflammatory chemotaxis to deliver colchicine for myocardial infarction therapy [0.03%]
一种生物杂化纳米囊泡通过劫持炎症趋化性向心肌梗死组织递送秋水仙素
Xiangyong Hu,Liping Du,Hongju Xiang et al.
Xiangyong Hu et al.
Introduction: Myocardial infarction (MI) triggers an excessive inflammatory response that drives adverse cardiac remodeling. Although colchicine has shown clinical promise, its narrow therapeutic window and lack of target...
Functional roles and applications of polysaccharides in biomedical and food systems [0.03%]
多糖在生物医学和食品体系中的功能作用及应用
A Atepileva,G Kudaibergen,T Krivoruchko et al.
A Atepileva et al.
Polysaccharides are renewable biopolymers widely used in biomedical and food systems because of their structural diversity, biodegradability, and biocompatibility. This review summarizes recent progress in the use of major polysaccharides, ...
Design and experimental study of a rigid-flexible coupled back rehabilitation robot [0.03%]
一种刚柔耦合的下肢康复外骨骼机器人设计与实验研究
Delin Kong,Yage Wang,Fu Mo et al.
Delin Kong et al.
Background: Existing spinal rehabilitation mechanisms present several limitations. These include a restricted range of motion, low flexibility, and suboptimal comfort. ...
Anticipatory prediction of sit-to-stand and stand-to-sit transitions: a unified approach [0.03%]
坐站过渡的预见性预测：统一方法
Kai Ren,Yuichi Nakamura,Kazuaki Kondo et al.
Kai Ren et al.
Introduction: Sit-to-stand (SiTSt ) and stand-to-sit (StTSi ) motions, collectively referred to as STS motions, are fundamental movements for independent daily living. However, many individuals are unable to generate suff...