Beyond glucose: wearable and implantable biosensors for continuous monitoring of metabolic, hormonal, and inflammatory biomarkers in personalized cardiometabolic care [0.03%]
超越葡萄糖：可穿戴和可植入式生物传感器在个性化心血管代谢护理中持续监测代谢、激素和炎症生物标志物中的应用
Hong Cai,Yehui He,Chaoyue Wang et al.
Hong Cai et al.
Wearable and implantable biosensors are shifting biochemical assessment from episodic laboratory testing to continuous, context-rich physiological monitoring. Glucose remains the most successful translational model because continuous glucos...
Stem cell-derived extracellular vesicles for high-altitude skin injuries: pathological mechanisms, advanced Nano-delivery, and translational perspectives [0.03%]
干细胞来源的外泌体在高原皮肤损伤中的应用：病理机制、先进纳米递送和转化医学视角
Yilin Wang,Huifang Yang,Kexin Tang et al.
Yilin Wang et al.
The extreme high-altitude environment-characterized by hypobaric hypoxia, intense ultraviolet radiation, and severe cold and aridity-imposes complex physical and biochemical stresses that synergistically drive pronounced cutaneous oxidative...
Injectable human tendon extracellular matrix via isopropanol-assisted delipidation and mild decellularization for tendon regeneration [0.03%]
异丙醇辅助去脂和温和脱细胞的人腱基质注射液促进肌腱再生
Jung Ki Lee,Jiyeon Mun,Hee Yeon Kim et al.
Jung Ki Lee et al.
Tendon injuries remain a major clinical challenge due to their limited intrinsic healing capacity and the shortcomings of current treatment options. Extracellular matrix (ECM)-based approaches are promising; however, most clinically availab...
Dehydrated silk fibroin matrices as versatile delivery systems for extracellular vesicles [0.03%]
脱水丝素基质作为外泌体输送系统
Alp Sarisoy,Yong Xu,Stephan Rütten et al.
Alp Sarisoy et al.
Extracellular vesicles (EVs) have emerged as promising alternatives to cell-based therapies due to their low immunogenicity, ability to carry therapeutic cargo, and enhanced stability. However, rapid clearance from the bloodstream and phago...
A nutrient-responsive cancer-on-chip model for assessing chemotherapy responses under glucose restriction [0.03%]
一种营养响应的癌症芯片模型，用于评估葡萄糖限制下的化疗反应评估
Andrea Giannoccaro,Maria Elisabetta Federica Palamà,Gianluca Ciardelli et al.
Andrea Giannoccaro et al.
Fasting-mimicking diets have emerged as promising adjuvant strategies to enhance chemotherapy efficacy. However, conventional preclinical models do not adequately reproduce the microenvironmental and transport-related conditions associated ...
Mechanical behavior of functionally zoned hybrid intracranial stent integrating laser-cut and braided architectures [0.03%]
集激光切割和编织结构于一体的分区杂化颅内支架的力学性能
Lei Ma,Mingxuan Li,Maosong Chen et al.
Lei Ma et al.
A novel functionally zoned hybrid intracranial stent is proposed to resolve the multifaceted mechanical limitations of existing designs by heterogeneously integrating a laser-cut anchoring segment with a braided section via interwoven filam...
Multi-cell-component cartilage organoids simulate intercellular microstress, hypoxic microenvironment, and chondrocyte-endothelial crosstalk in vitro [0.03%]
多细胞成分软骨类器官模拟体外软骨细胞内应力、低氧微环境和软骨细胞内皮细胞交叉谈话
Zhengchao Wang,Pengfei Zhu,Hongmei Li et al.
Zhengchao Wang et al.
Introduction: In cartilage-related studies, the existing in vitro cartilage models often fail to simulate the complex pathophysiology involving a hypoxic microenvironment, abnormal intercellular mechanical stress (microst...
Closing the implementation gap: a harmonised EU framework for synthetic nucleic acid screening and customer verification [0.03%]
缩小执行差距：欧盟合成核酸筛查和客户验证的统一框架
Sophie Peresson,Patrick Stadler
Sophie Peresson
Synthetic nucleic acid technologies underpin modern biological research and biomanufacturing. However, their growing accessibility through commercial synthesis services, benchtop devices, and AI-assisted design tools creates significant dua...
Resolving curling and swelling in cartilage and other deformation-prone tissue explant models: a scalable, simple load-predictive flattening method enabling standardized mechanical compression [0.03%]
解决软骨和其他易变形组织模型中卷曲和膨胀问题的简易方法：一种可预测载荷的规模化平整方法，使标准化机械压缩成为可能
Marlene Lechner,Melanie L Hart,Alan J Grodzinsky et al.
Marlene Lechner et al.
Introduction: Ex vivo swelling and curling can undermine reproducibility in compression-based injury models. Methods: We developed a si...
Nanostructured surfaces for enveloped virus inactivation: mechanisms and fabrication strategies [0.03%]
包膜病毒灭活的纳米结构表面：机制和制备策略
Jiayu Wang,Nana Zhou,Jiarui Qu et al.
Jiayu Wang et al.
Enveloped viruses, owing to the intrinsic sensitivity of their lipid envelopes to physical perturbations, have attracted increasing attention in the field of antiviral surface engineering. Compared with conventional chemical-based strategie...