Single center, real-world retrospective study of CAR-T cell therapy for relapsed/refractory large B-cell lymphoma beyond second line: five-year results at the University Hospitals Leuven [0.03%]
卢万大学医院CAR-T细胞治疗二线以后复发/难治大B细胞淋巴瘤的单中心真实世界回顾性研究五年结果
Jan Brijs,Jonas Van Ham,Benedicte Dubois et al.
Jan Brijs et al.
Introduction: Large B-cell lymphomas (LBCL) are the most frequently aggressive B-cell non-Hodgkin lymphomas. Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has emerged as a new, powerful treatment for relapsed o...
The first reported familial case of statin-induced immune-mediated necrotizing myopathy associated with anti-hydroxy-3-methylglutaryl-CoA reductase autoantibodies and HLA DRB1*11:01 [0.03%]
首例他汀类药物致免疫介导的坏死性肌病家系及其相关抗羟基-3-甲基戊二酰辅酶A还原酶自身抗体和HLA DRB1*11:01遗传易感因素报告
M Bronchain,L Pothen,L Taihi et al.
M Bronchain et al.
Immune-mediated necrotizing myopathy (IMNM) is a rare type of auto-immune myositis, characterized by symmetric muscle pain, proximal weakness, elevated serum CK levels and pathologic findings of necrotized muscle fibers. IMNM may be seroneg...
A case of VEXAS with microcytic anemia: don't be mislead by an associated condition! [0.03%]
一例伴有小细胞性贫血的VEXAS综合征病例：不要被伴随疾病误导！
Kenza Squalli,Louis Wolff,Frédéric Vandergheynst
Kenza Squalli
Background: VEXAS syndrome encompasses a wide range of rheumatological and hematological manifestations, which often features myelodysplastic syndrome accompanied by either macrocytic anemia or macrocytosis. ...
Outcomes of adjuvant immune checkpoint inhibitor therapy in melanoma: a retrospective study [0.03%]
黑色素瘤辅助免疫检查点抑制剂治疗的疗效回顾性研究
Fieuws Sarah,De Ridder Margot,Baert Valerie et al.
Fieuws Sarah et al.
Background: Adjuvant treatment of malignant melanoma has improved the outcomes for patients. However, real-world data on efficacy and safety are limited. We investigated outcomes of melanoma patients treated with adjuvant...
Immune landscape in the glomerular transcriptome of nephrotic syndrome and anca-associated vasculitis [0.03%]
肾病综合征和抗中性粒细胞胞浆抗体相关性血管炎的肾小球转录组免疫图谱
Si Feng,Jianwei Yi,Zhihong He et al.
Si Feng et al.
Background: ANCA-associated vasculitis (AAV), and nephrotic syndrome encompassing diseases including minimal change disease (MCD), focal and segmental glomerulosclerosis (FSG), membranous nephropathy (MN), remain a challe...
Enhancing hospital emergency response based on the experience of COVID-19 [0.03%]
基于新冠肺炎疫情经验改进医院应急响应措施
Tania Desmet,Peter De Paepe,Kristof Eeckloo
Tania Desmet
Introduction: The COVID-19 pandemic required a significant response from global healthcare systems. In Belgium, the crisis began in March 2020, prompting quick action in hospitals. This study assesses the effectiveness of...
Expansion of MALDI-TOF MS database as a strategy for identification of Haemophilus species other than H. influenzae [0.03%]
MALDI-TOF质谱数据库的扩展作为除流感嗜血杆菌外其他嗜血杆菌鉴定策略的研究
Eva Willems,Hannelore Hamerlinck,Anne-Sophie Messiaen et al.
Eva Willems et al.
Objectives: This study aimed to evaluate an expanded matrix-assisted laser desorption-ionization-time of flight mass spectrometry (MALDI-TOF MS) database for the identification of Haemophilus species other than H. influen...
Characteristics and outcomes of patients treated with sotrovimab to prevent progression to severe COVID-19 in Belgium [0.03%]
比利时用于防止COVID-19发展为重症的Sotrovimab治疗患者的特征和结局
Myriam Drysdale,Thor Hautekiet,Moushmi Singh et al.
Myriam Drysdale et al.
Objective: Sotrovimab, a dual-action, engineered human monoclonal antibody, has been demonstrated to significantly reduce the risk of hospitalisation and death in high-risk patients with COVID-19. Here, we describe the re...
Observational Study
Acta clinica Belgica. 2024 Jun;79(3):174-183. DOI:10.1080/17843286.2024.2381272 2024
The 2024 Flemish consensus on screening for gestational diabetes mellitus early and later in pregnancy [0.03%]
2024年胎儿期糖尿病筛查佛兰德共识：早期和晚期孕期筛查
Katrien Benhalima,Ina Geerts,Peggy Calewaert et al.
Katrien Benhalima et al.
Background: Screening for gestational diabetes mellitus (GDM) is important to improve pregnancy outcomes and to prevent type 2 diabetes after pregnancy. Due to a lack of evidence, the 2019 Flemish consensus did not recomm...
Retrospective analysis of a flucloxacillin oral absorption test in patients requiring flucloxacillin therapy: results and determination of factors associated with adequate absorption [0.03%]
氟氯西林口服吸收试验的回顾性分析：结果及充分吸收影响因素的确立
Sanne De Smet,Pieter De Cock,Nick Verougstraete et al.
Sanne De Smet et al.
Objectives: Flucloxacillin has the most narrow spectrum to treat staphylococcal infections, but has a large variability in bioavailability which hampers its intravenous (iv) to oral switch. To identify patients with adequ...