Tetanus toxin fragment C fused to flagellin makes a potent mucosal vaccine [0.03%]
与鞭毛素融合的破伤风毒素片断C成为一种有效的粘膜疫苗
Shee Eun Lee,Chung Truong Nguyen,Soo Young Kim et al.
Shee Eun Lee et al.
Purpose: Recombinant subunit vaccines provide safe and targeted protection against microbial infections. However, the protective efficacy of recombinant subunit vaccines tends to be less potent than the whole cell vaccine...
Vaccine adjuvant materials for cancer immunotherapy and control of infectious disease [0.03%]
癌症免疫治疗和控制传染性疾病的疫苗佐剂材料
Yong Taik Lim
Yong Taik Lim
Adjuvants can be defined as pharmacological and immunological components that are able to modify and/or enhance antigen-specific immune responses. Based on the interdisciplinary research between immunology and material science/engineering, ...
Clinical vaccine development [0.03%]
临床疫苗研发
Seunghoon Han
Seunghoon Han
Vaccination is regarded as one of the biggest triumphs in the history of medicine. We are living in the most successful period of vaccine development. The accumulation of multidisciplinary knowledge and the investment of massive funding hav...
Polyionic vaccine adjuvants: another look at aluminum salts and polyelectrolytes [0.03%]
聚离子型疫苗佐剂：铝盐和聚电解质的再观察
Bradford S Powell,Alexander K Andrianov,Peter C Fusco
Bradford S Powell
Adjuvants improve the adaptive immune response to a vaccine antigen by modulating innate immunity or facilitating transport and presentation. The selection of an appropriate adjuvant has become vital as new vaccines trend toward narrower co...
Ebola outbreak in Western Africa 2014: what is going on with Ebola virus? [0.03%]
2014年西非埃博拉疫情：埃博拉病毒怎么了？
Woonsung Na,Nanuri Park,Minju Yeom et al.
Woonsung Na et al.
The 2014 outbreak of Ebola virus disease (EVD) in West Africa, caused by Ebola virus (Zaire Ebola virus species), is the largest outbreak of EVD in history. It cause hemorrhagic fever in human and nonhuman primates with high mortality rate ...
Won Hyung Lee,Han Sang Yoo
Won Hyung Lee
There is no published guideline for the vaccination to pigs even though several vaccine companies suggested the program based on their products. It is very difficult to standardize the program because most of the veterinary vaccines are con...
Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain [0.03%]
O型口蹄疫病毒代表性疫苗毒株全长cDNA回复质粒的抗原性和致病性研究
Rae-Hyung Kim,Jia-Qi Chu,Jeong-Nam Park et al.
Rae-Hyung Kim et al.
We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in ...
Woo Young Choi,Kee-Jong Hong,Joo Eun Hong et al.
Woo Young Choi et al.
Since the first case of Ebola virus disease (EVD) in Guinea was reported in March 2014 by World Health Organization (WHO), the outbreak has continued through the year and the total number of 19,065 patients was reported as the confirmed or ...
Oral immunization of mice with recombinant rabies vaccine strain (ERAG3G) induces complete protection [0.03%]
新型口服狂犬病疫苗株的免疫效果研究
Dong-Kun Yang,Ha-Hyun Kim,Sung-Suk Choi et al.
Dong-Kun Yang et al.
Purpose: New rabies vaccine bait for both pets and raccoon dogs residing in Korea is needed to eradicate rabies infection among animals. In this study, we constructed a recombinant rabies virus (RABV), the ERAG3G strain, ...
Improvement of DNA vaccination by adjuvants and sophisticated delivery devices: vaccine-platforms for the battle against infectious diseases [0.03%]
佐剂和精良递送设备改良DNA疫苗：对抗传染病的疫苗平台
Thomas Grunwald,Sebastian Ulbert
Thomas Grunwald
Advantages of DNA vaccination against infectious diseases over more classical immunization methods include the possibilities for rapid manufacture, fast adaptation to newly emerging pathogens and high stability at ambient temperatures. In a...