Peter A Corning
Peter A Corning
A major theoretical issue in evolutionary biology over the past two decades has concerned the rise of complexity over time in the natural world, and a search has been underway for "a Grand Unified Theory" - as biologist Daniel McShea charac...
Keith Baverstock
Keith Baverstock
The case has been made that the-gene-centric approach to biology, which has prevailed over the past ~100 years, should be replaced by a fundamental framework based on the cell being a far from equilibrium complex dissipative system, regulat...
Denis Noble,George Ellis
Denis Noble
Multilevel interpretations of development and evolution take to heart the contextual nature of both those processes, and so necessarily assume top-down causation occurs, right down to the physics level. In this article we revisit the Princi...
Denis Noble,Raymond Noble
Denis Noble
The idea of The Selfish Gene, first published in 1976, grew out of the Modern Synthesis of evolutionary biology formulated by Julian Huxley in 1942, and more specifically from George Williams' Adaptation and Natu - ral Selection in 1966. It...
The third-way third wave and the enduring appeal of bioexceptionalism [0.03%]
第三条道路的第三次浪潮以及生物特殊性的持久吸引力
Erik L Peterson
Erik L Peterson
We may induce from a longue durée examination of Anglo-American History of Biology that the impulse to reject reduc - tionism persists and will continue to percolate cyclically. This impulse I deem "bioexceptionalism": an intuition, stance...
David Lambert
David Lambert
Editorial
Theoretical biology forum. 2022 Jan 1;115(1-2):9-10. DOI: 2022
DNA methylation correlation structure of chromosome 21 in Down syndrome [0.03%]
21三体综合症中染色体21的DNA甲基化关联结构
Iva Budimir,Claudia Sala,Maria Giulia Bacalini et al.
Iva Budimir et al.
DNA methylation studies usually focus on the groups of CpG sites. Neighbouring CpG sites are analyzed together due to their group behaviour. However, this approach ignores the possible interaction between more distant CpG sites. In this wor...
Multivariate functional partial least squares for classification using longitudinal data [0.03%]
基于纵向数据的多元函数偏最小二乘分类方法
Sonia Dembowska,Alex Frangi,Jeanine Houwing-Duistermaat et al.
Sonia Dembowska et al.
The use of statistical methods to predict outcomes using high dimensional datasets in medicine is becoming increasingly popular for forecasting and monitoring patient health. Our work is motivated by a longitudinal dataset containing 1H NMR...
Angga M Fuady,Said El Bouhaddani,Hae-Won Uh et al.
Angga M Fuady et al.
Multiple technologies which measure the same omics data set but are based on different aspects of the molecules exist. In practice, studies use different technologies and have therefore different biomarkers. An example is the glycan age ind...
Use of shared gamma frailty model in analysis of survival data in twins [0.03%]
利用共享伽玛脆弱性模型分析双胞胎生存数据
Annah Mwikali Muli,Arief Gusnanto,Jeanine Houwing-Duistermaat
Annah Mwikali Muli
In survival analysis, the effect of a covariate on the outcome is reported in a hazard rate. However, hazards rates are hard to interpret. Here we consider differences in survival probabilities instead. Using data on twins is interesting du...