H Nessighaoui,M Lilamand,K V Patel et al.
H Nessighaoui et al.
Frailty is a multidimensional syndrome, involving functional, nutritional, biological and psychological aspects. This condition, defined as a decreased resistance to internal and external stressors, is predictive of adverse health outcomes,...
Co-Presence of Multimorbidity and Disability with Frailty: An Examination of Heterogeneity in the Frail Older Population [0.03%]
多病共存与衰弱老年人残疾同现及其异质性研究
S Aarts,K V Patel,M E Garcia et al.
S Aarts et al.
Background: Frailty is often associated with multimorbidity and disability. Objectives: We investigated heterogeneity in the frail olde...
Frailty and Sarcopaenia Trials in Primary Care - Identifying and Overcoming Key Barriers to Successful Clinician Participation [0.03%]
社区初级保健环境下的衰弱和肌少症试验——识别并克服临床医生成功参与的关键障碍
A Sinclair
A Sinclair
Primary care research involving older people brings together a wide range of primary care practitioners. Key areas of activity include: health promotion, disease prevention, screening and early diagnosis, as well as the management of common...
Use of Biomarkers [0.03%]
生物标志物的应用
L Rodríguez-Mañas
L Rodríguez-Mañas
Expanding the concept of frailty to the clinical settings has raised the concern about the accuracy of the current definitions for identifying frail individuals (not populations). The usual tools to assess frailty show, among other characte...
A Phase 2 Randomized Study Investigating the Efficacy and Safety of Myostatin Antibody LY2495655 versus Placebo in Patients Undergoing Elective Total Hip Arthroplasty [0.03%]
评估万拉妥单抗与安慰剂在择期全髋关节置换术患者中疗效和安全性的2期随机研究
L Woodhouse,R Gandhi,S J Warden et al.
L Woodhouse et al.
Background: Total hip arthroplasty relieves joint pain in patients with end stage osteoarthritis. However, postoperative muscle atrophy often results in suboptimal lower limb function. There is a need to improve functiona...
Clinical Trial
The Journal of frailty & aging. 2016;5(1):62-70. DOI:10.14283/jfa.2016.81 2016
V M Castañeda Morales,A M Jiménez Garduño,M V Escárcega et al.
V M Castañeda Morales et al.
Chronic pain is defined as pain lasting longer than six weeks and is one of the main complaints in elderly subjects. Frailty is a pathological condition that increases an individual's vulnerability by diminishing their homeostatic reserve, ...
Observational Study
The Journal of frailty & aging. 2016;5(1):59-61. DOI:10.14283/jfa.2015.71 2016
Dietary Protein to Maintain Muscle Mass in Aging: A Case for Per-meal Protein Recommendations [0.03%]
关于保持肌肉质量的膳食蛋白质摄入量：有关每餐蛋白质摄取建议的一个案例分析
C H Murphy,S Y Oikawa,S M Phillips
C H Murphy
It is well accepted that daily protein intake is an important dietary consideration to limit and treat age-related declines in muscle mass, strength, and function. Furthermore, we propose that there is a growing appreciation for the need to...
Frailty and Constellations of Factors in Aging HIV-infected and Uninfected Women--The Women's Interagency HIV Study [0.03%]
妇女HIV感染与老龄化因素——女性间机构HIV研究
D R Gustafson,Q Shi,M Thurn et al.
D R Gustafson et al.
Background: Biological similarities are noted between aging and HIV infection. Middle-aged adults with HIV infection may present as elderly due to accelerated aging or having more severe aging phenotypes occurring at youn...
Muscle Disuse as a Pivotal Problem in Sarcopenia-related Muscle Loss and Dysfunction [0.03%]
肌肉失用在与 sarcopenia 相关的肌肉丢失和功能障碍中的核心问题
K E Bell,M T von Allmen,M C Devries et al.
K E Bell et al.
An age-associated loss of muscle mass and strength--sarcopenia--begins at around the fifth decade of life, with mass being lost at ~0.5-1.2% per year and strength at ~3% per year. Sarcopenia can contribute to a variety of negative health ou...