Oncolytic myxoma virus synergizes with standard of care for treatment of glioblastoma multiforme [0.03%]
溶瘤性黏液瘤病毒与标准疗法联合治疗多形性胶质母细胞瘤产生协同效应
Chase Burton,Arabinda Das,Daniel McDonald et al.
Chase Burton et al.
Background: Glioblastoma multiforme (GBM) is an aggressive form of brain cancer which is associated with poor prognosis. A variety of oncolytic viruses have previously shown positive efficacy against GBM, potentially offe...
Oral poliovirus vaccine-induced programmed cell death involves both intrinsic and extrinsic pathways in human colorectal cancer cells [0.03%]
口服脊髓灰质炎病毒疫苗诱导的程序性细胞死亡涉及人类结直肠癌细胞中的内在和外在途径
Sareh Zhand,Seyed Masoud Hosseini,Alijan Tabarraei et al.
Sareh Zhand et al.
Purpose: Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. Replication-competent viruses, which are naturally able to infect and lyse tumor cells, seem to be promising in this ...
Linus D Kloker,Can Yurttas,Ulrich M Lauer
Linus D Kloker
Oncolytic virotherapy constitutes an upcoming alternative treatment option for a broad spectrum of cancer entities. However, despite great research efforts, there is still only a single US Food and Drug Administration/European Medicines Age...
Chun-Yu Chen,Brian Hutzen,Mary F Wedekind et al.
Chun-Yu Chen et al.
Oncolytic viruses are lytic for many types of cancers but are attenuated or replication-defective in normal tissues. Aside from tumor lysis, oncolytic viruses can induce host immune responses against cancer cells and may thus be viewed as a...
Matthew B Phillips,Johnasha D Stuart,Roxana M Rodríguez Stewart et al.
Matthew B Phillips et al.
Mammalian orthoreovirus (reovirus) is under development as a cancer virotherapy. Clinical trials demonstrate that reovirus-based therapies are safe and tolerated in patients with a wide variety of cancers. Although reovirus monotherapy has ...
Oncolytic adenovirus Ad657 for systemic virotherapy against prostate cancer [0.03%]
用于系统病毒治疗前列腺癌的溶瘤腺病毒Ad657
Tien V Nguyen,Catherine M Crosby,Gregory J Heller et al.
Tien V Nguyen et al.
Background: Human species C adenovirus serotype 5 (Ad5) is the archetype oncolytic adenovirus and has been used in the vast majority of preclinical and clinical tests. While Ad5 can be robust, species C Ad6 has lower sero...
Proof-of-principle that a decoy virus protects oncolytic measles virus against neutralizing antibodies [0.03%]
诱饵病毒能够保护条件致病性 measles virus 肿瘤病毒避免中和抗体的攻击原理证明实验
Chun Xu,Annika Verena Goß,Carmen Dorneburg et al.
Chun Xu et al.
Background: Attenuated oncolytic measles virus (OMV) is a promising antitumor agent in early-phase clinical trials. However, pre-existing immunity against measles might be a hurdle for OMV therapy. ...
The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses [0.03%]
肿瘤溶瘤病毒的体内分布的影像策略的重要性
Adrian Pelin,Jiahu Wang,John Bell et al.
Adrian Pelin et al.
Oncolytic viruses (OVs) are an emergent and unique therapy for cancer patients. Similar to chemo- and radiation therapy, OV can lyse (kill) cancer cell directly. In general, the advantages of OVs over other treatments are primarily: a highe...
Raquel Yokoda,Bolni M Nagalo,Mansi Arora et al.
Raquel Yokoda et al.
Upper gastrointestinal tract malignancies are among the most challenging cancers with regard to response to treatment and prognosis. Cancers of the esophagus, stomach, pancreas, liver, and biliary tree have dismal 5-year survival, and very ...
Eric Bartee
Eric Bartee
Multiple myeloma (MM) is a clonal malignancy of plasma cells that is newly diagnosed in ~30,000 patients in the US each year. While recently developed therapies have improved the prognosis for MM patients, relapse rates remain unacceptably ...