Anti-tumor Effects of Recombinant Clostridium α-Toxin on Breast Cancer: An In Vitro and In Vivo Study [0.03%]
重组芽胞杆菌α毒素抗肿瘤作用的体内外研究
Nahid Rezaei Khozani,Mohammad Shayesteh Pour,Mina Yekani et al.
Nahid Rezaei Khozani et al.
Cancer is the second leading cause of death worldwide, surpassed only by cardiovascular diseases. This study investigated the anticancer effects of recombinant Clostridium α-toxin on breast cancer, both in vitro and in vivo. The entire cod...
Potential Otubain1 Inhibitor, an Approach for a Treatment against Breast Cancer [0.03%]
潜在的Otubain1抑制剂，一种治疗乳腺癌的新方法
Andrea Muñoz-Ayala,Victor G García-González,Angel Pulido-Capiz et al.
Andrea Muñoz-Ayala et al.
The develop of new anticancer drug continues worldwide and one of the new therapeutic targets to reach it is Otubain 1 (OTUB1), since OTUB1 has functions related to prognosis in a variety of tumors and is strongly related to tumor prolifera...
O-6-Methylguanine-DNA Methyltransferase, C-MYC, and EBER Status in Diffuse Large B-Cell Lymphoma of Central Nervous System [0.03%]
中枢神经系统弥漫大B细胞淋巴瘤中O-6-甲基鸟嘌呤-DNA-甲基转移酶、C-MYC及EBER状态的研究
Alireza Sadeghipour,Hadi Mohagheghian,Sajjadeh Movahedinia et al.
Alireza Sadeghipour et al.
Diffuse Large B-cell Lymphoma (DLBCL), the most common type of primary central nervous system lymphoma (PCNSL), is a rare aggressive subtype of DLBCL with a poorly understood biology. This study aimed to investigate the prevalence of O-6-Me...
SiRNA-mediated Silencing of the RPS19 Gene Induces Apoptosis and Inhibits Cell Cycle Progression in Chronic Myeloid Leukemia Cells [0.03%]
RPS19基因的siRNA干扰诱导慢性髓系白血病细胞凋亡及抑制细胞周期进展的作用机制研究
Javad Roodgar-Saffari,Vajiheh Zarrinpour,Mohammad Mahdi Forghanifard
Javad Roodgar-Saffari
This research delves into the therapeutic implications of utilizing small interfering RNA (siRNA) to target the ribosomal protein S19 (RPS19) gene in chronic myeloid leukemia (CML) using the K562 cell line model. The primary objective was t...
Enhancing the Cardiogenic Potential of Human Mesenchymal Stem Cells via Extracellular Matrix Proteins [0.03%]
利用细胞外基质蛋白增强人源间充质干细胞的心肌分化潜能
Galina Chizhikova,Mikhail Khotin,Natalya Bildyug
Galina Chizhikova
Current in vitro models of cardiogenic differentiation include a variety of manipulations and stimulating agents, which interfere with the application of such models for preclinical drug testing. So, the aim of this study was to develop an ...
Ferroptosis Plays a Pivotal Role in Activating and Modulating Specific Intracellular Signaling Pathways Integrated into the Therapeutic Management of Colorectal Cancer [0.03%]
铁死亡在激活和调节特定细胞内信号通路中的核心作用及其在结直肠癌治疗管理中的整合效应研究
Marzieh Monemi,Hanan Hassan Ahmed,Radhwan Abdul Kareem et al.
Marzieh Monemi et al.
It is expected that the amount of recently diagnosed colon cancer cases will increase to around 3.2 million yearly until 2040. Although early diagnostic procedures and management approaches have been improved, colorectal cancer (CRC) treatm...
Differential Gene Expression and Tumorigenicity Analysis of Cultured Melanocyte Comparing Melanoma [0.03%]
与黑色素瘤对比培养黑色素细胞的基因差异表达及肿瘤发生力分析
Atefeh Shahbazi,Seyed Jalal Zargar,Amir Bajouri et al.
Atefeh Shahbazi et al.
This study aimed to identify the optimal growth media for culturing human skin melanocytes for clinical applications and to assess their tumorigenic potential both in vitro and in vivo. Various growth media were tested to determine the most...
Metformin as a Potential Therapeutic Agent in Breast Cancer: Targeting miR-125a Methylation and Epigenetic Regulation [0.03%]
二甲双胍作为乳腺癌治疗药物的潜力：靶向miR-125a甲基化和表观遗传调控
Fatemeh Ahmadpour,Somayeh Igder,Ali Reza Eftekhari Moghadam et al.
Fatemeh Ahmadpour et al.
Breast cancer, characterized by genetic diversity and molecular subtypes, presents significant treatment challenges, especially in human epidermal growth factor receptor type 2 (HER2)-positive cases, which are associated with poor prognosis...
Lactobacillus Plantarum and its Derived Bacteriocin Exhibits Potent Antitumor Activity against Esophageal Cancer Cells [0.03%]
植物乳杆菌及其衍生细菌素对食管癌细胞具有 potent antitumor活性
Salam Husam Sabri,Saeed Esmaeili Mahani,Ahmed Majeed Al-Shammari et al.
Salam Husam Sabri et al.
Esophageal cancer presents a challenge in gastroenterology and traditional chemotherapy and radiation therapy have less therapeutic activity with severe side effects. Thus, there is need for effective and safer alternatives. Probiotics, par...
An In Silico Study of Transforming Growth Factor-β Inhibitors: A Potential Target for Diabetic Nephropathy Treatment with Active Compounds from the Active Fraction of Physalis angulata [0.03%]
基于计算的研究：Physalis angulata 活性组分中转化生长因子-β抑制剂的潜在靶标及其活性化合物对糖尿病肾病的治疗作用
Ika Rahayu,Nur Arfian,Kris Herawan Timotius et al.
Ika Rahayu et al.
Transforming growth factor beta (TGF-β) initiates epithelial-mesenchymal transition (EMT) in tubular and glomerular epithelial cells, resulting in excessive production and deposition of extracellular matrix through its interaction with TGF...