O-6-Methylguanine-DNA Methyltransferase, C-MYC, and EBER Status in Diffuse Large B-Cell Lymphoma of Central Nervous System [0.03%]
中枢神经系统弥漫大B细胞淋巴瘤中O-6-甲基鸟嘌呤-DNA-甲基转移酶、C-MYC及EBER状态的研究
Alireza Sadeghipour,Hadi Mohagheghian,Sajjadeh Movahedinia et al.
Alireza Sadeghipour et al.
Diffuse Large B-cell Lymphoma (DLBCL), the most common type of primary central nervous system lymphoma (PCNSL), is a rare aggressive subtype of DLBCL with a poorly understood biology. This study aimed to investigate the prevalence of O-6-Me...
SiRNA-mediated Silencing of the RPS19 Gene Induces Apoptosis and Inhibits Cell Cycle Progression in Chronic Myeloid Leukemia Cells [0.03%]
RPS19基因的siRNA干扰诱导慢性髓系白血病细胞凋亡及抑制细胞周期进展的作用机制研究
Javad Roodgar-Saffari,Vajiheh Zarrinpour,Mohammad Mahdi Forghanifard
Javad Roodgar-Saffari
This research delves into the therapeutic implications of utilizing small interfering RNA (siRNA) to target the ribosomal protein S19 (RPS19) gene in chronic myeloid leukemia (CML) using the K562 cell line model. The primary objective was t...
Enhancing the Cardiogenic Potential of Human Mesenchymal Stem Cells via Extracellular Matrix Proteins [0.03%]
利用细胞外基质蛋白增强人源间充质干细胞的心肌分化潜能
Galina Chizhikova,Mikhail Khotin,Natalya Bildyug
Galina Chizhikova
Current in vitro models of cardiogenic differentiation include a variety of manipulations and stimulating agents, which interfere with the application of such models for preclinical drug testing. So, the aim of this study was to develop an ...
Ferroptosis Plays a Pivotal Role in Activating and Modulating Specific Intracellular Signaling Pathways Integrated into the Therapeutic Management of Colorectal Cancer [0.03%]
铁死亡在激活和调节特定细胞内信号通路中的核心作用及其在结直肠癌治疗管理中的整合效应研究
Marzieh Monemi,Hanan Hassan Ahmed,Radhwan Abdul Kareem et al.
Marzieh Monemi et al.
It is expected that the amount of recently diagnosed colon cancer cases will increase to around 3.2 million yearly until 2040. Although early diagnostic procedures and management approaches have been improved, colorectal cancer (CRC) treatm...
Differential Gene Expression and Tumorigenicity Analysis of Cultured Melanocyte Comparing Melanoma [0.03%]
与黑色素瘤对比培养黑色素细胞的基因差异表达及肿瘤发生力分析
Atefeh Shahbazi,Seyed Jalal Zargar,Amir Bajouri et al.
Atefeh Shahbazi et al.
This study aimed to identify the optimal growth media for culturing human skin melanocytes for clinical applications and to assess their tumorigenic potential both in vitro and in vivo. Various growth media were tested to determine the most...
Metformin as a Potential Therapeutic Agent in Breast Cancer: Targeting miR-125a Methylation and Epigenetic Regulation [0.03%]
二甲双胍作为乳腺癌治疗药物的潜力：靶向miR-125a甲基化和表观遗传调控
Fatemeh Ahmadpour,Somayeh Igder,Ali Reza Eftekhari Moghadam et al.
Fatemeh Ahmadpour et al.
Breast cancer, characterized by genetic diversity and molecular subtypes, presents significant treatment challenges, especially in human epidermal growth factor receptor type 2 (HER2)-positive cases, which are associated with poor prognosis...
Lactobacillus Plantarum and its Derived Bacteriocin Exhibits Potent Antitumor Activity against Esophageal Cancer Cells [0.03%]
植物乳杆菌及其衍生细菌素对食管癌细胞具有 potent antitumor活性
Salam Husam Sabri,Saeed Esmaeili Mahani,Ahmed Majeed Al-Shammari et al.
Salam Husam Sabri et al.
Esophageal cancer presents a challenge in gastroenterology and traditional chemotherapy and radiation therapy have less therapeutic activity with severe side effects. Thus, there is need for effective and safer alternatives. Probiotics, par...
An In Silico Study of Transforming Growth Factor-β Inhibitors: A Potential Target for Diabetic Nephropathy Treatment with Active Compounds from the Active Fraction of Physalis angulata [0.03%]
基于计算的研究：Physalis angulata 活性组分中转化生长因子-β抑制剂的潜在靶标及其活性化合物对糖尿病肾病的治疗作用
Ika Rahayu,Nur Arfian,Kris Herawan Timotius et al.
Ika Rahayu et al.
Transforming growth factor beta (TGF-β) initiates epithelial-mesenchymal transition (EMT) in tubular and glomerular epithelial cells, resulting in excessive production and deposition of extracellular matrix through its interaction with TGF...
Enhancement of the Sensitivity of the Acute Lymphoblastic Leukemia Cells to ABT-737 by Formononetin [0.03%]
金雀异黄素增强急性淋巴细胞白血病细胞对ABT-737敏感性的作用及机制研究
Yusef Abbasi,Marziyeh Pooladi,Roya Nazmabadi et al.
Yusef Abbasi et al.
Overexpression of (myeloid leukemia cell differentiation protein 1) Mcl-1 is associated with the reduction of ABT-737 toxicity and secondary resistance. In this study, the effect of formononetin (biochanin B) on Mcl-1 expression, cell growt...
Circulating miRNA-106b-5p As a Potential Biomarker for Coronary Artery Disease [0.03%]
循环miRNA-106b-5p作为冠状动脉疾病潜在标志物的研究
Rosita Azar Bahadori,Dina Shabani,Elham Arjmandrad et al.
Rosita Azar Bahadori et al.
Coronary artery diseases (CAD) represent a significant global health concern and are recognized as a primary contributor to mortality on a worldwide scale. Early diagnosis of CAD is one of promising goal to manage this disorder. Recent inve...