Trace Amine-associated Receptor 1: Role in the Implementation of Neuroprotective Signaling Pathways [0.03%]
追踪胺相关受体1：在实施神经保护信号通路中的作用
Mikhail Voevoda,Dmitry Filimonov,Roman Knyazev et al.
Mikhail Voevoda et al.
Trace amine-associated receptor 1 (TAAR1) is a classical representative of G-protein coupled receptors (GPCRs). It is widely distributed in the mammalian brain, potentially plays an important role in modulating neurotransmitter functions an...
Synergistic Efficacy of Dual-Target HSA-Based Delivery for HER and VEGFR Co-Blockade in Triple-Negative Breast Cancer [0.03%]
HER和VEGFR协同阻断治疗三阴性乳腺癌的双重靶向人血白蛋白基药物递送体系的协同疗效研究
Sadegh Rostaminasab,Sahar Memarkashani,Tahereh Rahdari et al.
Sadegh Rostaminasab et al.
Resistance to monotherapies targeting receptor tyrosine kinases remains a major challenge in triplenegative breast cancer (TNBC). Here, we developed a dualtarget HSAbased nanobioconjugate combining human serum albumin (HSA)-encapsulated lap...
From Bench to Bedside: Translating Research on miR-138 miR-195-5p and Long Non-Coding RNA H19 into Therapeutic Applications of Orthodontic Tooth Movement [0.03%]
从实验室到临床：将关于miR-138、miR-195-5p和长链非编码RNA H19的最新研究成果转化成牙齿矫治力的研究进展及应用展望
Dorsa Nikeghbal,Sajjad Rostamzadeh,Sarah Qutaiba Badraldeen et al.
Dorsa Nikeghbal et al.
This research investigates the roles of microRNAs (miR-138, miR-195-5p) and the long non-coding RNA (lncRNA) H19 in orthodontic tooth movement (OTM). A literature review using databases such as PubMed and Scopus identified 148 articles, whi...
Prevalence of Antibiotic Resistance Determinants in Carbapenem-Resistant Pseudomonas aeruginosa: Focus on Class 1 and 2 Integrons and bla IMP Gene [0.03%]
碳青霉烯耐药铜绿假单胞菌blaIMP基因、Ⅰ类和Ⅱ类整合子的流行情况及分布特征分析
Maryam Behboudipour,Neda Soleimani,Negar Azarpira et al.
Maryam Behboudipour et al.
As a leading non-fermentative opportunistic bacterium, Pseudomonas aeruginosa (P. aeruginosa) plays a major role in healthcare-associated infections. The emergence of carbapenem-resistant strains is a serious clinical threat, often associat...
Vitamin E incorporated in Carboxymethyl Cellulose-Gelatin Hydrogel Increases Wound Healing [0.03%]
以羧甲基纤维素-明胶水凝胶为载体的维生素E促进伤口愈合效果更佳
Seyed Reza Mousavi,Mojtaba Rashidi,Azam Khedri et al.
Seyed Reza Mousavi et al.
Improving wound care products to facilitate effective skin repair is very important. Hydrogels are promising polymer-based dressings that enhance wound healing. Vitamin E can improve skin injuries by increasing antioxidant capacity. This st...
Genetic Insights and Clinical Implications in the Diagnosis of Acute Myeloid Leukemia: An Updated Perspective [0.03%]
急性髓系白血病诊断的遗传学见解及临床意义：最新视角
Elahe Razmara Lak,Aziz Eghbali,Omid Kiani Ghalesardi et al.
Elahe Razmara Lak et al.
Pediatric acute myeloid leukemia (AML) is biologically heterogeneous, necessitating integrated genetic and immunophenotypic profiling for precise diagnosis and risk stratification. We analyzed 74 pediatric AML patients diagnosed between 201...
Evidence for a TMAO-HULC-miRNA regulatory axis in colorectal cancer cells [0.03%]
一种与结直肠癌有关的TMAO-HULC-miRNA调控轴的证据
Zahra Alighardashi,Mohammad Moradzad,Sonya Najafpour et al.
Zahra Alighardashi et al.
Colorectal cancer (CRC) is a malignancy with a significant global disease burden.Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, has been implicated in tumorigenesis. The oncogenic long non-coding RNA highly upregulated ...
Melatonin Ameliorates 5-Fluorouracil-Induced Cytotoxicity and Apoptosis in H9c2 Cell Line: Insights into Cytoprotection and Anti-Apoptotic Mechanisms [0.03%]
褪黑素通过细胞保护和抗凋亡机制缓解5-氟尿嘧啶诱导的H9c2细胞毒性和凋亡
Sama Torkashvand,Sohrab Kazemi,Razieh Mansoori et al.
Sama Torkashvand et al.
Cardiotoxicity represents a significant adverse effect associated with 5-fluorouracil (5-FU), a widely used chemotherapeutic agent. Melatonin (MLT), a powerful antioxidant and agent that prevents apoptosis, has shown promise in mitigating v...
Investigating the role of transforming growth factor-beta/transforming growth factor-beta receptor in the development of hepatocellular carcinoma through the Salvador-Warts-Hippo pathway [0.03%]
转化生长因子β/转化生长因子β受体通过萨尔瓦多-warts-霍皮通路在肝细胞癌发生发展中的作用机制研究
Samaneh Moradi,Radhwan Abdul Kareem,Hayder Naji Sameer et al.
Samaneh Moradi et al.
A key component of the Hippo signaling pathway (HSP) is a kinase cascade that connects the tumor suppressor Hippo to the oncoprotein Yki (YAP and TAZ). This oncoprotein functions as a transcriptional coactivator for target genes that play c...
Potential Protective Effects of Cerium Oxide Nanoparticles on Ultraviolet-B Irradiated Fibroblast Cells [0.03%]
纳米氧化铈对紫外线照射成纤维细胞的潜在保护作用
Reza Fardid,Mansooreh Mostafavi Mendi,Gholamhassan Haddadi et al.
Reza Fardid et al.
Increased environmental ultraviolet-B (UVB) exposure stimulates reactive oxygen species (ROS) overproduction, disrupts cellular redox balance, and contributes to skin disorders. Antioxidants inhibit autoxidation by neutralizing or suppressi...