Mesenchymal Stem Cells Therapy Led to the Improvement of Spatial Memory in Rats with Alzheimer's disease Through Changing the Expression of LncRNA TUSC7/ miR-449a/ PPARγ and CD36 Genes in the Brain Tissue [0.03%]
间充质干细胞治疗通过改变阿尔茨海默病大鼠脑组织中长链非编码RNA TUSC7/miR-449a/PPARγ和CD36基因的表达改善空间记忆
Seyedeh Pardis Pezeshki,Mehrnaz Karimi Darabi,Zahra Nazeri et al.
Seyedeh Pardis Pezeshki et al.
Mesenchymal stem cells (MSCs) have the ability to phagocytize amyloid beta (Aβ) plaques and lower inflammation through the activity of microglia. Peroxisome proliferator-activated receptor gamma (PPARγ) is a protein involved in reducing i...
Stigmasterol- an Acetylcholinesterase Inhibitor from Phormidium retzii with relevance to Alzheimer's disease Therapy [0.03%]
菜油甾醇—来自胶被束丝藻的乙酰胆碱酯酶抑制剂及其对阿尔茨海默病治疗的意义
Rincy Yesudas,Vinoth Kumar Thirumalairaj,Geetharamani Durairaj et al.
Rincy Yesudas et al.
This study observed in vitro screening, purification and identification of cholinesterase inhibitors from the microalgae Phormidium retzii. Mixed microalgal culture was screened from freshwater samples for Phormidium sp. Single colony was p...
Early Diagnosis of Alzheimer's Disease with Blood Test; Tempting but Challenging [0.03%]
用血液检测实现阿尔茨海默病的早期诊断；诱惑与挑战并存
Fakhrossadat Farvadi,Fatemeh Hashemi,Azadeh Amini et al.
Fakhrossadat Farvadi et al.
The increasing prevalence of Alzheimer's disease (AD) has led to a health crisis. According to official statistics, more than 55 million people globally have AD or other types of dementia, making it the sixth leading cause of death. It is s...
Evaluation of Inhibitory Effect of Abatacept (CTLA4-ig) and Conditioned Medium of Mesenchymal Stem Cell in an Acetic Acid-induced Mouse Model of Acute Colitis [0.03%]
在醋酸诱导的急性结肠炎小鼠模型中对阿巴西普(CTLA4-Ig)和间充质干细胞培养上清抑制作用的评估
Manizhe Faghih,Mona Moshiri,Fatemeh Ahmadzadeh et al.
Manizhe Faghih et al.
An individual with a genetic predisposition to inflammatory bowel disease (IBD) can experience inflammatory responses leading to conditions such as Crohn's disease (CD) or Ulcerative colitis (UC). Currently, stem cell therapies, particularl...
Expression Assessment of the Helicobacter pyloribabA and sabA Genes in Patients with Peptic Ulcer, Duodenal Ulcer and Gastric Cancer [0.03%]
幽门螺杆菌babA和sabA基因在消化性溃疡、十二指肠溃疡及胃癌患者中表达分析
Javad Shokri Shirvani,Maryam Salehi,Amirmohammad Rezaei Majd et al.
Javad Shokri Shirvani et al.
Helicobacter pylori as a common gastrointestinal (GI) pathogen must possess certain virulence characteristics to colonize the stomach, evade host immune responses, and subsequently induce GI diseases. This research aimed to investigate the ...
Inflammatory Responses of Women with Polycystic Ovary Syndrome in Vitro Differ from Healthy Women [0.03%]
多囊卵巢综合征患者与正常女性体外炎症反应差异研究
Fatemeh Rezayat,Mehri Hajiaghayi,Nazanin Ghasemi et al.
Fatemeh Rezayat et al.
Polycystic ovary syndrome is a low-grade inflammatory state with increased serum levels of TNF-α. The present study has compared the inflammatory responses to breast cancer cell lines in women with PCOS with healthy women. Peripheral blood...
Effects of hsa-piR-32877 Suppression with Antisense LNA GapmeRs on the Proliferation and Apoptosis of Human Acute Myeloid Leukemia Cells [0.03%]
反义LNA gapmeRs抑制hsa-piR-32877对人急性髓系白血病细胞增殖和凋亡的影响
Sepideh Nasseri,Mohammadreza Sharifi,Valiollah Mehrzad
Sepideh Nasseri
Acute myeloid leukemia (AML) is an invasive form of hematologic malignancies which results in the overproduction of myeloid cells in the bone marrow. Aberrant expression of piwi-interacting RNAs (piRNAs) which belong to small non-coding RNA...
Amyloid Beta Alters the Expression of microRNAs Regulating HMGCR and ABCA1 Genes in Astrocytes of C57BL/6J Mice [0.03%]
淀粉样蛋白 β 改变小鼠 astrocytes 中调控 HMGCR 和 ABCA1 基因的 microRNA 的表达
Hossein Azizi Dariuni,Mehrnaz Karimi Darabi,Zahra Nazeri et al.
Hossein Azizi Dariuni et al.
Dysregulation of brain cholesterol homeostasis causes the accumulation of extracellular protein deposits called amyloid plaques in the hippocampus which eventually leads to neuronal death, memory and learning deficits. The aim of the presen...
P19 a Parthenin Analog Induces Cell Lineage Dependent Apoptotic and Immunomodulatory Signaling in Acute Lymphoid Leukemia Cells [0.03%]
一种类似帕瑟汀的化合物P19通过细胞谱系依赖性的凋亡和免疫调节信号作用于急性淋巴细胞性白血病细胞
Vishal Sharma,Samriti Dhawan,Ajay Kumar et al.
Vishal Sharma et al.
Leukemia is a type of cancer that affects the blood and bone marrow. Acute lymphoid leukaemia, also known as ALL, is regarded as one of the deadliest forms of cancer. Due to the rapid increase in various cancer cases and the development of ...
Mutational Analysis and Genotype Investigation of Less Known Gaucher Mutations through Haplotype Analysis in Iranian Gaucher Patients [0.03%]
伊朗戈谢病患者中少见戈谢病突变的谱系分析及基因型研究
Negar Sardarpour,Hamideh Bagherian,Fatemeh Zafarghandi Motlagh et al.
Negar Sardarpour et al.
Gaucher's disease (GD) is the most frequent lysosomal storage disorder resulting from a deficiency of the enzyme glucocerebrosidase (GBA) which causes the accumulation of glucocerebroside. More than 500 mutations have been reported on the G...