Geremia Zito Marinosci,Edoardo De Robertis,Giuseppe De Benedictis et al.
Geremia Zito Marinosci et al.
Dopamine is still frequently used as a first line vasopressor agent in hypotensive patients, when physicians are afraid of noradrenaline and believe that dopamine, with its β and α, inotrope and vasopressor effects, may be helpful. Eviden...
A new long-term reversible contraception method: sexual and metabolic impact [0.03%]
长期可逆避孕法的新型方法：对性生活和代谢的影响
F Visconti,F Zullo,M L Marra et al.
F Visconti et al.
Background: Data relating to the influence of hormonal contraception on sexual life are conflicting and mostly they refer to oral contraceptives. In this study we evaluated the effect of a long-acting contraceptive on sex...
To NFκB or not to NFκB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator [0.03%]
抑制癌症细胞命运调节物NF-κB的难题：能不能抑及要不要抑？
Daniela Sorriento,Maddalena Illario,Rosa Finelli et al.
Daniela Sorriento et al.
Nuclear factor κB (NFκB) is a transcription factor that plays an important role in carcinogenesis as well as in the regulation of inflammatory response. NFκB is constitutively expressed in tumours where it induces the expression of genes...
Sisters Acts: Converging Signaling Between CaMKII and CaMKIV, Two Members of the Same Family [0.03%]
同门近亲的汇聚信号转导：蛋白激酶CaMKII和CaMKIV姐妹间的相互作用
M R Rusciano,A S Maione,M Illario
M R Rusciano
Calcium (Ca(2+)) is a universal second messenger that regulates a number of diverse cellular processes including cell proliferation, development, motility, secretion, learning and memory1, 2. A variety of stimuli, such as hormones, growth f...
Minimally invasive Swine experimental model for the in vivo study of liver metabolism of drugs [0.03%]
用于体内研究肝脏药物代谢的微创猪实验模型
O Piazza,R Romano,G Scarpati et al.
O Piazza et al.
Purpose: To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. Materials a...
Giulia Paolella
Giulia Paolella
Intra-regional, extra-regional and international health mobility are important phenomena for regional and national healthcare planning. Pediatric data on this topic are scarce. We therefore conducted a systematic literature search on the Pu...
Environmental pollution effects on reproductive health - clinical-epidemiological study in southern Italy [0.03%]
意大利南部有关环境污染物对生殖健康影响的临床流行病学研究
M L Marra,F Zullo,B De Felice et al.
M L Marra et al.
This study aims to address the clinical, statistical and Epidemiological Relationship Between Birth Defects and Environmental Pollution, in the Campania Region and in Salerno. ...
An engineering approach to biomedical sciences: advanced testing methods and pharmacokinetic modeling [0.03%]
工程化生物医学研究方法：先进检测技术与药代动力学模型
Gaetano Lamberti,Sara Cascone,Giuseppe Titomanlio
Gaetano Lamberti
In this paper, the philosophy of a research in pharmacology field, driven by an engineering approach, was described along with some case histories and examples. The improvement in the testing methods for pharmaceutical systems (in-vitro tec...
Allergens in allergy diagnosis: a glimpse at emerging new concepts and methodologies [0.03%]
过敏原在过敏诊断中的作用：新兴概念和方法的展望
Ivana Giangrieco,Chiara Rafaiani,Marina Liso et al.
Ivana Giangrieco et al.
Allergic diseases are important concern of public health. A reliable diagnosis is of utmost importance for the management of allergic patients both when immunotherapy is planned and when the treatment is essentially based on the avoidance o...
1,4-dihydropyridines: the multiple personalities of a blockbuster drug family [0.03%]
1,4-二氢吡啶类药物： blockbuster 药物家族的多重人格
Mauro Cataldi,Fiorentina Bruno
Mauro Cataldi
More than 40 years after their introduction in therapy, 1,4-dihydropyridines (DHPs) are still amongst the most prescribed drugs in the world. Though they all share a similar mechanism of action blocking L-type voltage-gated Ca(2+) channels,...